Integra NeuroSciences Features AccuDrain External CSF Drainage System at the Congress of Neurological Surgeons Annual Meeting

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| Source: Integra LifeSciences Holdings Corp.

PLAINSBORO, N.J., Oct. 12, 2005 (PRIMEZONE) -- Integra LifeSciences Holdings Corporation (Nasdaq:IART) announced that it is featuring the AccuDrain(TM) External CSF Drainage System at the 55th Annual Meeting of the Congress of Neurological Surgeons in Boston Massachusetts this week. The AccuDrain System is Integra NeuroSciences' most advanced external ventricular and lumbar drainage (EDS) system.

"The AccuDrain System has exceeded our expectations," said Joanna Zanko RN, BSN, Nurse Manager for the Neuroscience Units at St. Lukes -- Roosevelt Hospital in New York City. "The advanced design and safety features have made this system our first choice in the management of our neurocritical care patients."

The AccuDrain System is an external ventricular and lumbar drainage (EDS) system that is used to drain cerebral spinal fluid (CSF) from patients who suffer from increased cranial pressure due to trauma or surgery. When it was launched earlier this year, the AccuDrain System introduced several unique design features to the market, including an antimicrobial and hydrophobic filter. The system can be laid down with the antimicrobial filter in contact with CSF fluids for up to 30 minutes, an improvement over other systems. The AccuDrain System can also be safely used in proximity to magnetic resonance imaging (MRI) equipment. As a result, patients using the system can be moved to radiology for MRI imaging without detaching the system.

The AccuDrain System does not require the use of an independent mounting system and is therefore easier for clinicians to use in situations where patients have to be moved within the hospital. Other unique design features include an exclusive dual action lever that allows the system to be easily and quickly attached to an IV pole, a unique squeeze-lok(TM) mechanism for simple and secure adjustment of the burette drip chamber, and needleless sampling sites, both at the patient line and burette, which promote ease of use and safety for the nurses who use the system. In addition, the AccuDrain System has an easy-to-read pressure scale and more prominent labeling of the CSF access points.

The AccuDrain System is sold through the Integra NeuroSciences(TM) sales organization. Integra NeuroSciences is a leading provider of implants, devices, instruments, and systems used in neurosurgery, neuromonitoring, neuro-trauma, and related critical care. Integra NeuroSciences' direct selling effort in the United States and Europe currently involves more than 130 professionals. In all other markets, Integra NeuroSciences products are sold through a network of distributors.

Integra LifeSciences Holdings Corporation is a diversified medical technology company. Integra develops, manufactures, and markets medical devices used in a variety of applications. The primary applications for our products are neuro-trauma and neurosurgery, reconstructive surgery and general surgery. Integra is a leader in applying the principles of biotechnology to medical devices that improve patients' quality of life. Our corporate headquarters are in Plainsboro, New Jersey, and we have research, manufacturing and distribution facilities located throughout the world. We have approximately 1,300 employees. Please visit our website at (http://www.Integra-LS.com).

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning the use of our AccuDrain System. Such forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results. Among other things, the willingness of physicians to use the AccuDrain System may affect the prospects for its use in clinical procedures. In addition, the economic, competitive, governmental, technological and other factors identified under the heading "Factors That May Affect Our Future Performance" included in the Business section of Integra's Annual Report on Form 10-K for the year ended December 31, 2004 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results.

Integra LifeSciences Holdings Corporation
 John B. Henneman, III
 Executive Vice President
 Chief Administrative Officer
 (609) 936-2481
  

 Maria Platsis
 Senior Director of Corporate Development and
 Investor Relations
 (609) 936-2333