NOTIFICATION UNDER CHAPTER 2, SECTION 10 OF THE FINNISH SECURITIES MARKET ACT REGARDING A CHANGE IN


BIOTIE THERAPIES CORP.        STOCK EXCHANGE ANNOUNCEMENT
                              9 January 2007 at 4.15 p.m.


NOTIFICATION UNDER CHAPTER 2, SECTION 10 OF THE FINNISH SECURITIES
MARKET ACT REGARDING A CHANGE IN HOLDINGS

Biotie Therapies Corp. (the “Company”) has received the following
notifications under Chapter 2, Section 9 of the Finnish Securities
Market Act regarding a change in holdings:

As a result of 11,365,242 new shares being issued on 27 December
2007 by Biotie Therapies Corp., the aggregate holdings of Pequot
Healthcare Fund, L.P., Pequot Healthcare Offshore Fund, Inc.,
Premium Series PCC Limited – Cell 32, Pequot Diversified Master
Fund, Ltd., Pequot Healthcare Institutional Fund, L.P. and Pequot
Healthcare Emerging Markets Fund, Ltd. (jointly, the “Funds”) have
decreased from 25.09% to 23.16% of the share capital and voting
rights in the Company, calculated on the basis of the number of
shares registered in the Finnish Trade Register. As a result of
the new shares being issued, no individual Fund has decreased its
holdings below or above 5% of the voting rights and share capital
of the company.

 Shareholder                            Number of  Proportion of
                                        shares     share capital
                                                   and voting
                                                   rights

 Pequot Healthcare Fund, L.P.            7,213,845      8.06%
 Pequot Healthcare Offshore Fund, Inc.   5,486,483      6.13%
 Premium Series PCC Limited – 32 Cell      998,490      1.12%
 Pequot Diversified Master Fund, Ltd.    1,201,800      1.34%
 Pequot Healthcare Institutional Fund,   1,337,806      1.49%
 L.P
 Pequot Healthcare Emerging Markets      4,500,000      5.03%
 Fund, Ltd.

Turku, 9 January 2007

Timo Veromaa


President and CEO

For further information, please contact:
Timo Veromaa, President and CEO, Biotie Therapies Corp.
tel. +358 2 274 8901, e-mail: timo.veromaa@biotie.com

www.biotie.com

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