Announcement no. 3/2007 To OMX Nordic Exchange Hørsholm, 5 March 2007 LifeCycle Pharma announces its financial results for the financial year 2006 Summary: The board of directors of LifeCycle Pharma today approved the financial statements for the financial year 2006. The company recorded an operating loss of DKK 149.1 million for 2006 compared to DKK 94.3 million in 2005. The company had a cash position of DKK 464.7 million by year end 2006 compared to DKK 87.2 million by year end 2005. The results for 2006 were in line with management's expectations for 2006. LifeCycle Pharma A/S (OMX: LCP) announced today that the board of directors approved the financial statements for the financial year 2006. The financial highlights for LifeCycle Pharma for the financial year 2006 compared with 2005 are set out below. LifeCycle Pharma's operating loss for 2006 was DKK 149.1 million and the net loss was DKK 147.7 million. The corresponding operating loss and net loss for 2005 totaled DKK 94.3 million and DKK 95.2 million, respectively. The increase is primarily attributable to the increasing level of clinical activities arising from the advancement of the company's product pipeline. Revenues increased from DKK 2.8 million in 2005 to DKK 9.7 million in 2006. The increased revenue is attributable to the company's collaboration agreements with Sandoz, Recordati and Merck Generics. Research and development costs increased by DKK 48.5 million, or by 60%, from DKK 80.9 million in 2005 to DKK 129.4 million in 2006. The increase in research and development costs is primarily attributable to the increased level of clinical activities arising from the advancement of LifeCycle Pharma's product pipeline. On an overall basis, research and development costs account for 86.8% of our total operations costs in 2006 compared to 84.2% in 2005, when adjusted for warrant compensation. General and administrative expenses increased by DKK 13.2 million, or by 82%, from DKK 16.2 million in 2005 to DKK 29.4 million in 2006. The increase in general and administrative expenses is primarily attributable to a significant increase in warrant compensation expenses in 2006. Warrant compensation expenses increased by DKK 9.0 million, from DKK 1.0 million in 2005 to DKK 10.0 million in 2006. Despite the significant increase in general and administrative expenses, on an overall basis, general and administrative expenses share of our total costs of operations has decreased in 2006 to 13.2% compared to 15.8% in 2005, when adjusted for warrant compensation. Net financial income increased by DKK 2.1 million, from financial expenses of DKK 0.8 million in 2005 to financial income of DKK 1.3 million for 2006. This increase reflects the impact of the strengthening of our cash position by the completion of the IPO on the OMX Nordic Exchange in November 2006. LifeCycle Pharma had a cash position of DKK 464.7 million by 31 December 2006. During 2006, the company's operating activities required cash flow of DKK 125.8 million compared to DKK 86.8 million in 2005. The increase is primarily due to increasing research and development costs reflecting the increasing level of clinical activities arising from the advancement of LifeCycle Pharma's product pipeline. The net cash flow from financing activities was DKK 510.5 million in 2006. This reflects primarily the cash inflow from the completion of the IPO on the OMX Nordic Exchange in November 2006, resulting in net proceeds of approximately DKK 500 million. Total expenses incurred in connection with the IPO amounted to approx. DKK 56.5 million. The following key figures and financial ratios have been calculated in accordance with the recommendations of the Association of Danish Financial Analysts. Key figures comply with the requirements under IFRS and the Danish financial reporting requirements. All key figures and financial ratios conform with the current accounting policies. Key Figures and ratios DKK -------------------------------------------------------------------------------- | Income Statement | 2006 | 2005 | 2004 | 2003 | 2002(1) | | for the period 1 January - | | | | | | | 31 December | | | | | | | (In thousands, except per | | | | | | | share data) | | | | | | -------------------------------------------------------------------------------- | Revenue | 9,740 | 2,754 | 4,648 | 190 | 0 | -------------------------------------------------------------------------------- | Research and development | (129,40 | (80,919 | (36,542 | (8,743) | (3,180) | | costs | 3) | ) | ) | | | -------------------------------------------------------------------------------- | Administrative expenses | (29,395 | (16,170 | (12,543 | (6,607) | 0 | | | ) | ) | ) | | | -------------------------------------------------------------------------------- | Operating loss | (149,05 | (94,335 | (44,437 | (15,160 | (3,180) | | | 8) | ) | ) | ) | | -------------------------------------------------------------------------------- | Net Financial expenses | 1,345 | (834) | (281) | 140 | 125 | | /Income | | | | | | -------------------------------------------------------------------------------- | Net loss for the year | (147,71 | (95,169 | (44,718 | (15,020 | (3,055) | | | 3) | ) | ) | ) | | -------------------------------------------------------------------------------- | Basic and diluted earnings | (7.65) | (6.82) | (4.58) | (3.00) | (0.90) | | per share | | | | | | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Balance sheet at 31 | 2006 | 2005 | 2004 | 2003 | 2002(1) | | December | | | | | | | (In thousands) | | | | | | -------------------------------------------------------------------------------- | Assets | | | | | | | -------------------------------------------------------------------------------- | Total non-current | 29,891 | 28,245 | 18,744 | 5,569 | 1,451 | | | assets | | | | | | | -------------------------------------------------------------------------------- | Cash and cash | 464,65 | 87,224 | 9 | 10,621 | 7,986 | | | equivalents | 8 | | | | | | -------------------------------------------------------------------------------- | Total current assets | 477,16 | 108,11 | 5,794 | 11,832 | 8,423 | | | | 6 | 2 | | | | | -------------------------------------------------------------------------------- | Total assets | 507,05 | 136,35 | 24,538 | 17,401 | 9,875 | | | | 7 | 7 | | | | | -------------------------------------------------------------------------------- | Equity and liabilities | | | | | | | -------------------------------------------------------------------------------- | Equity | 458,08 | 92,430 | (1,647 | 14,130 | 6,946 | | | | 3 | | ) | | | | -------------------------------------------------------------------------------- | Total current | 24,309 | 18,647 | 10,030 | 3,271 | 2,929 | | | liabilities | | | | | | | -------------------------------------------------------------------------------- | Total liabilities | 48,974 | 43,927 | 26,185 | 3,271 | 2,929 | | -------------------------------------------------------------------------------- | Total equity and | 507,05 | 136,35 | 24,538 | 17,401 | 9,875 | | | liabilities | 7 | 7 | | | | | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Investment in property, | 7,222 | 13,572 | 15,169 | 4,348 | 510 | | plant & equipment | | | | | | -------------------------------------------------------------------------------- Key Figures and ratios DKK -------------------------------------------------------------------------------- | Cash flow | 2006 | 2005 | 2004 | 2003 | 2002 | | | | statement | | | | | (1) | | | | for the period 1 | | | | | | | | | January - 31 | | | | | | | | | December | | | | | | | | | (In thousands) | | | | | | | | -------------------------------------------------------------------------------- | Cash flow from | (125,81 | (86,771 | (43,53 | (15, | (504 | | | | | operating | 3) | ) | 0) | 057) | ) | | | | | activities | | | | | | | | | -------------------------------------------------------------------------------- | Cash flow from | (7,222) | (13,572 | (15,16 | (4,3 | (1,5 | | | | | investing | | ) | 9) | 48) | 10) | | | | | activities | | | | | | | | | -------------------------------------------------------------------------------- | Cash flow from | 510,469 | 187,558 | 48,087 | 22,0 | 10,0 | | | | | financing | | | | 40 | 00 | | | | | activities | | | | | | | | | -------------------------------------------------------------------------------- | Cash and cash | 464,658 | 87,224 | 9 | 10,6 | 7,98 | | | | | equivalents at 31 | | | | 21 | 6 | | | | | December | | | | | | | | | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Other financial data | 2006 | 2005 | 2004 | 2003 | 2002(1 | | | | | | | | | ) | | | -------------------------------------------------------------------------------- | Number of fully paid | 30,369 | 4,428, | 2,634 | 1,746 | 1,000, | | | | Shares in issue as at | ,816 | 569 | ,269 | ,370 | 000 | | | | 31 December (2) | | | | | | | | -------------------------------------------------------------------------------- | Weighted average number | 19,313 | 13,965 | 9,768 | 5,014 | 3,402, | | | | of Shares during the | ,737 | ,252 | ,052 | ,244 | 136 | | | | year (3) | | | | | | | | -------------------------------------------------------------------------------- | Asset/equity at year | 1.11 | 1.48 | N/A | 1.23 | 1.42 | | | | end | | | | | | | | -------------------------------------------------------------------------------- | Average number of | 44 | 35 | 21 | 8 | 4 | | | | employees for the | | | | | | | | | year | | | | | | | | | (full-time | | | | | | | | | equivalents) | | | | | | | | -------------------------------------------------------------------------------- (1) Key figures and ratios for 2002 have been altered compared to the Annual Report for 2002. The alteration concerns the presentation of operating expenses. The alteration/preparation has not been audited. (2) At a board meeting held 5 December 2005 the share capital was increased by 509,551 Shares. 67,824 Shares were paid in after 31 December 2005. (3) Weighted average number of shares during 2002-2005 has been adjusted according to the issue of bonus shares in the ration 1:3 2006 Highlights The key event for LifeCycle Pharma in 2006 was the listing of the company's shares on the OMX Nordic Exchange on 13 November 2006. Through the initial public offering (IPO), LifeCycle Pharma raised approx. DKK 500 million in net proceeds by offering a total of 12.65 million new shares at an offer price of DKK 44 per share. This IPO was essential in securing a strong financial foundation for the continued clinical development of our existing products as well enabling us to further develop our new product candidates through pre-clinical development and clinical trials. Another significant event was the submission of an New Drug Application (NDA) to the U.S. Food And Drug Administration (“FDA”) under Section 505(b)(2) to produce and market our LCP-FenoChol product for a cholesterol lowering indication in the United States. As reported in December, the FDA accepted our NDA for review. This submission evidences LifeCycle Pharma's strong research and development capabilities, as in less than 4 years we have been able to bring a product candidate from the initial idea stage to FDA submission. In addition to the above key highlights, LifeCycle Pharma passed a number of other significant milestones in 2006. The most important business and scientific milestones were: Positive Pivotal data for LCP-FenoChol demonstrating that LifeCycle Pharma's LCP-FenoChol has an improved absorption compared to Antara® as well as no food effect Positive pilot Phase I data for LCP-Tacro, an anti-rejection product used in organ transplantation care, demonstrating once-daily profile as well as a more than 49% increase in bioavailability compared to Prograf®. Additional Phase I clinical studies were initiated in September 2006 Granted Sandoz exclusive U.S. rights and Merck Generics exclusive European rights to develop and commercialize LCP-Feno, a cholesterol lowering product Expanded our cooperation with Recordati regarding the collaboration for LCP-Lerc Entered into a service agreement with Lundbeck where Lundbeck will use the MeltDose Technology for two of their new pre-clinical compounds Initiation of Phase I clinical studies for LCP-AtorFen a combination product consisting of two cholesterol lowering agents, fenofibrate and atorvastatin Grant of first EU patent for MeltDose Technology Outlook for 2007 During 2007, LifeCycle Pharma will continue to advance the development of the company's 6 named product candidates, one of which is under FDA registration review and the other five are in various stages of clinical development. The company's scientific team will continuously investigate promising new product candidates for potential addition to our growing product pipeline. In 2007, LifeCycle Pharma expects to be advancing LCP-FenoChol through the FDA review process to ensure that the product is ready for introduction to the United States market in the beginning of 2008. Introduction of such a product into the United States market requires sales capabilities that LifeCycle Pharma does not currently posses and the company is currently pursuing the possibility to outlicense LCP-FenoChol as an alternative to building a sales team in the United States at this stage. Further, LifeCycle Pharma plans to initiate two Phase II clinical trials with LCP-Tacro to treat organ transplant patients and patients with auto-immune diseases. Also, in February 2007, the company received positive clinical data for its Phase I program with LCP-AtorFen and the company plans to initiate a Phase II clinical program with LCP-AtorFen to treat patients with abnormal lipid levels. Finally, LifeCycle Pharma expects to expand its existing product pipeline with one named product by advancing one of our internal pre-clinical product candidates into clinical trials during 2007. As costs will increase for the expanded regulatory and clinical development activities, LifeCycle Pharma's operating expenses are expected to be significantly higher in 2007 compared to 2006. In 2007, LifeCycle Pharma is projecting an operating loss of DKK 260 to 285 million compared to DKK 149 million for 2006. Under the conditions described above, the net loss for 2007 is expected to be in the range of DKK 255 to 280 million compared to the net loss of DKK 148 million in 2006. As of 31 December 2006, the company's cash position equalled approximately DKK 465 million and the company's projected 31 December 2007 cash position is expected to be in the range of DKK 215 to 240 million. The above estimates are subject to possible change primarily due to the timing and variation of clinical activities, related costs and fluctuating exchange rates. The estimates also assume that no further outlicense agreements are entered into during 2007 that could materially affect the results. The 2006 Annual Report is expected to be available on our home page on 12 March 2007. The management of LifeCycle Pharma will hold a telephone conference call to discuss the company's 2006 Full Year results on Tuesday 6 March 2007 at 3pm CET (2pm GMT/9am Eastern) The dial-in details for the call are as follows: Participants in Denmark: 70 26 50 40 Participants outside Denmark: +45 70 26 50 40 Ask for the LifeCycle Pharma conference call. The conference call will be held in English. We very much look forward to you joining the call. An archived version of the call will be subsequently available on the LifeCycle Pharma website www.lcpharma.com Grant of warrants Also today, the board of directors decided to issue 160,000 warrants to new employees. No members of the company's board or management were granted warrants. Of the 160,000 warrants, 155,000 warrants are allocated to key employees and the remaining 5,000 warrants are allocated to other employees. Each warrant entitles the holder to subscribe one share of nominal DKK 1 in the company against cash contribution equal to the closing price of the company's shares at the OMX Nordic Exchange on March 6, 2007, to ensure that the exercise price reflects the fair market price per share following the disclosure of the preliminary annual report. By application of the Black-Scholes formula, the market value of the warrant program can be calculated as DKK 17.77 per warrant assuming an exercise price of DKK 54.50, equal to the closing price of the company's share at the OMX Nordic Exchange on March 5, 2007, based on an interest rate of 4.00% and a volatility of the company's shares set to 35%. The aim of the issue is to give an incentive to the new employees to work towards a positive development in the company's business and by extension, an increase in the market price of the company's shares. The warrants vest by 1/48th per month of employment after the date of grant. The exercise periods are determined as 21 days from the company's announcements of its preliminary annual report and the interim financial report for the first half of a year, respectively. The first exercise period is 21 days after publication of the preliminary annual report for 2007 and the last exercise period is 21 days from publication of the interim financial period for the first half of 2013. The board of directors has issued the warrants by partly exercising the authorization contained in Article 8 of the company's articles of association according to which the board of directors - for a period ending on 1 July 2011 - on one or more occasions may issue up to 500,000 warrants each conferring a right to subscribe 1 share of nominally DKK 1 each in Lifecycle Pharma without preemptive subscription rights for the shareholders. After the issue of the 160,000 warrants, 211,619 warrants remain available for issue under the authorization and the total number of warrants issued in the company is 4,983,712 warrants. Income Statement for the period 1 January - 31 December (In thousands) -------------------------------------------------------------------------------- | | 2006 | 2005 | 2006 | 2005 | | | DKK | DKK | *EUR | *EUR | -------------------------------------------------------------------------------- | Revenue | 9,740 | 2,754 | 1,306 | 370 | -------------------------------------------------------------------------------- | Research and development costs | (129,403 | (80,919) | (17,356) | (10,853) | | | ) | | | | -------------------------------------------------------------------------------- | Administrative expenses | (29,395) | (16,170) | (3,942) | (2,169) | -------------------------------------------------------------------------------- | Operating loss | (149,058 | (94,335) | (19,992) | (12,652) | | | ) | | | | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Financial income | 2,993 | 945 | 402 | 127 | -------------------------------------------------------------------------------- | Financial expenses | (1,648) | (1,779) | (221) | (239) | -------------------------------------------------------------------------------- | Loss before tax | (147,713 | (95,169) | (19,811) | (12,764) | | | ) | | | | -------------------------------------------------------------------------------- | Tax for the year | 0 | 0 | 0 | 0 | -------------------------------------------------------------------------------- | Net loss for the year | (147,713 | (95,169) | (19,811) | (12,764) | | | ) | | | | -------------------------------------------------------------------------------- The board of directors proposes the net loss be carried forward to next year. -------------------------------------------------------------------------------- | | 2006 | 2005 | 2006 | 2005 | -------------------------------------------------------------------------------- Basic and diluted EPS (in DKK / EUR) (7.65) (6.82) (1.03) (0.91) Weighted average number of shares(1) 19,313,737 13,965,252 * The figures in EUR have been translated for convenience. These figures are unaudited (1) Weighted average number of shares during 2005 has been adjusted according to the issue of bonus shares in the ration 1:3 Balance Sheet - Assets at 31 December (In thousands) -------------------------------------------------------------------------------- | | 2006 | 2005 | 2006 | 2005 | | | DKK | DKK | *EUR | *EU | | | | | | R | -------------------------------------------------------------------------------- | Licenses and rights | 779 | 829 | 104 | 111 | -------------------------------------------------------------------------------- | Intangible assets | 779 | 829 | 104 | 111 | -------------------------------------------------------------------------------- | Process plant and machinery | 23,184 | 16,310 | 3,110 | 2,188 | -------------------------------------------------------------------------------- | Other fixtures and fittings, | 80 | 195 | 11 | 26 | | tools and equipment | | | | | -------------------------------------------------------------------------------- | Leasehold improvements | 5,848 | 6,636 | 784 | 890 | -------------------------------------------------------------------------------- | Prepayments for property, | 0 | 4,275 | 0 | 573 | | plant and equipment | | | | | -------------------------------------------------------------------------------- | Property, plant and equipment | 29,112 | 27,416 | 3,905 | 3,677 | -------------------------------------------------------------------------------- | Non-current assets | 29,891 | 28,245 | 4,009 | 3,788 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Receivables from capital | 0 | 9,889 | 0 | 1,326 | | increase | | | | | -------------------------------------------------------------------------------- | Trade Receivables | 6,707 | 0 | 900 | 0 | -------------------------------------------------------------------------------- | Other receivables | 5,430 | 8,609 | 728 | 1,155 | -------------------------------------------------------------------------------- | Prepayments | 371 | 2,390 | 50 | 321 | -------------------------------------------------------------------------------- | Receivables | 12,508 | 20,888 | 1,678 | 2,802 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Cash and cash equivalents | 464,658 | 87,224 | 62,320 | 11,698 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Current assets | 477,166 | 108,112 | 63,998 | 14,500 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Assets | 507,057 | 136,357 | 68,007 | 18,288 | -------------------------------------------------------------------------------- * The figures in EUR have been translated for convenience. These figures are unaudited Balance Sheet - Equity and Liabilities at 31 December (In thousands) -------------------------------------------------------------------------------- | | 2006 | 2005 | 2006 | 2005 | | | DKK | DKK | *EU | *E | | | | | R | UR | -------------------------------------------------------------------------------- | Share capital | 30,370 | 4,429 | 4,073 | 594 | -------------------------------------------------------------------------------- | Share premium | 717,039 | 242,822 | 96,169 | 32,567 | -------------------------------------------------------------------------------- | Retained earnings/loss | (289,326) | (154,821) | (38,804) | (20,765) | -------------------------------------------------------------------------------- | Equity | 458,083 | 92,430 | 61,438 | 12,396 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Finance lease | 24,665 | 25,280 | 3,308 | 3,391 | -------------------------------------------------------------------------------- | Non-current liabilities | 24,665 | 25,280 | 3,308 | 3,391 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Finance lease | 6,081 | 5,044 | 816 | 677 | -------------------------------------------------------------------------------- | Trade payables | 11,957 | 10,714 | 1,604 | 1,437 | -------------------------------------------------------------------------------- | Deferred Revenue | 373 | 0 | 50 | 0 | -------------------------------------------------------------------------------- | Debt to shareholders | 166 | 46 | 22 | 6 | -------------------------------------------------------------------------------- | Other payables | 5,732 | 2,843 | 769 | 381 | -------------------------------------------------------------------------------- | Current liabilities | 24,309 | 18,647 | 3,261 | 2,501 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Liabilities | 48,974 | 43,927 | 6,569 | 5,892 | -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- | Equity and liabilities | 507,057 | 136,357 | 68,007 | 18,288 | -------------------------------------------------------------------------------- * The figures in EUR have been translated for convenience. These figures are unaudited Cash Flow Statement for the period 1 January - 31 December -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 2006 DKK 2005 DKK 2006 *EUR 2005 *EUR Operating loss(149,058)(94,335)(19,992)(12,652)Share-based payment13,2082,0401,771274Depreciation and amortisation 5,5764,071748546Working capital changes3,1162,287418308Cash flow from operating activities before interest(127,158)(85,937)(17,055)(11,526)Interest received2,993945402127Interest paid(1,648)(1,779)(221)(239)Cash flow from operating activities(125,813)(86,771)(16,874)(11,638)Purchase of property, plant and equipment(7,222)(13,572)(969)(1,820)Cash flow from investing activities(7,222)(13,572)(969)(1,820)Proceeds from bank borrowings and finance lease 5,25114,1827051,902Instalment on bank borrowings and finance lease(4,829)(3,941)(648)(529)Proceeds from issuance of shares, net510,047177,31768,40823,782Cash flow from financing activities510,469187,55868,46525,155Increase/decrease in cash and cash equivalents377,43487,21550,62211,697Cash and cash equivalent, 1 January 87,224911,6981Cash and cash equivalents at 31 December 464,65887,22462,32011,698Cash and cash equivalents comprise 31 December:Deposit on demand and cash464,65887,22462,32011,698(In thousands) * The figures in EUR have been translated for convenience. These figures are unaudited Statement of Change in Equity 1 January 2006 - 31 December 2006 (In thousands, except number of shares) -------------------------------------------------------------------------------- | | Number | Share | Share | Retained | Total | Total | | | of | capit | premiu | earnings | DKK | *EUR | | | shares | al | m | /loss | | | | | | DKK | DKK | DKK | | | -------------------------------------------------------------------------------- | Equity as of | 4,428,56 | 4,429 | 242,82 | (154,821 | 92,430 | 12,397 | | 1 January 2006 | 9 | | 2 | ) | | | -------------------------------------------------------------------------------- | Comprehensive | 0 | 0 | 0 | (147,713 | (147,713 | (19,811 | | income: | | | | ) | ) | ) | | Net loss for the | | | | | | | | year | | | | | | | -------------------------------------------------------------------------------- | Total | 0 | 0 | 0 | (147,713 | (147,713 | (19,811 | | comprehensive | | | | ) | ) | ) | | income | | | | | | | -------------------------------------------------------------------------------- | Issuance of | 12,650,0 | 12,65 | 543,95 | 0 | 556,600 | 74,651 | | shares | 00 | 0 | 0 | | | | -------------------------------------------------------------------------------- | Warrant exercise | 1,385 | 1 | 42 | 0 | 43 | 6 | -------------------------------------------------------------------------------- | Share-based | 0 | 0 | 0 | 13,208 | 13,208 | 1,771 | | payment | | | | | | | -------------------------------------------------------------------------------- | Bonus shares | 13,289,8 | 13,29 | (13,29 | 0 | 0 | 0 | | | 62 | 0 | 0) | | | | -------------------------------------------------------------------------------- | Cost related to | 0 | 0 | (56,48 | 0 | (56,485 | (7,576 | | capital increase | | | 5) | | ) | ) | -------------------------------------------------------------------------------- | Equity as of | 30,369,8 | 30,37 | 717,03 | (289,326 | 458,083 | 61,438 | | 31 December 2006 | 16 | 0 | 9 | ) | | | -------------------------------------------------------------------------------- The share capital is not available for distribution, while other reserves are distributable for dividend purposes subject to the provision of the Danish Public Company Act. * The figures in EUR have been translated for convenience. These figures are unaudited Statement of Change in Equity 1 January 2005 - 31 December 2005 (In thousands, except number of shares) -------------------------------------------------------------------------------- | | Number | Share | Share | Retained | Total | Total | | | of | capita | premiu | earnings | DKK | *EUR | | | shares | l | m | /loss | | | | | | DKK | DKK | DKK | | | -------------------------------------------------------------------------------- | Equity as of | 2,634,2 | 2,634 | 57,411 | (61,692) | (1,647) | (221) | | 1 January 2005 | 69 | | | | | | -------------------------------------------------------------------------------- | Comprehensive | 0 | 0 | 0 | (95,169) | (95,169) | (12,764 | | income: | | | | | | ) | | Net loss for the | | | | | | | | year | | | | | | | -------------------------------------------------------------------------------- | Total | 0 | 0 | 0 | (95,169) | (95,169) | (12,764 | | comprehensive | | | | | | ) | | income | | | | | | | -------------------------------------------------------------------------------- | Issuance of | 1,784,0 | 1,785 | 186,27 | 0 | 188,062 | 25,223 | | shares | 22 | | 7 | | | | -------------------------------------------------------------------------------- | Warrant exercise | 10,278 | 10 | 314 | 0 | 324 | 43 | -------------------------------------------------------------------------------- | Share-based | 0 | 0 | 0 | 2,040 | 2,040 | 274 | | payment | | | | | | | -------------------------------------------------------------------------------- | Cost related to | 0 | 0 | (1,180 | 0 | (1,180) | (158) | | capital increase | | | ) | | | | -------------------------------------------------------------------------------- | Equity as of | 4,428,5 | 4,429 | 242,82 | (154,821 | 92,430 | 12,397 | | 31 December 2005 | 69 | | 2 | ) | | | -------------------------------------------------------------------------------- * The figures in EUR have been translated for convenience. These figures are unaudited For further information please contact: LifeCycle Pharma A/S Dr. Flemming Ørnskov Michael Wolff Jensen President & CEO Executive VP & CFO Tel.: +45 24 20 03 68 Tel.: +45 40 74 62 44 --oo0oo--- About LifeCycle Pharma: LifeCycle Pharma is an emerging pharmaceutical company with a broad and late stage product pipeline in therapeutic areas of cholesterol management, hypertension and organ transplant. LifeCycle Pharma's most advanced product has been filed with the U.S. FDA and is expected to enter the US market in the first quarter of 2008. LifeCycle Pharma's product candidates are proprietary and designed to improve the quality of existing drugs by enhancing the release and absorption of drugs in the human body. LifeCycle Pharma's proprietary technology platform, MeltDose® technology, offers lower dosing, reduced side effects and improved safety and patient compliance as well as reduced product development time and production costs. LifeCycle Pharma has formed several partnerships with major pharmaceutical companies and is clinically developing product candidates within a number of areas, including cholesterol management, hypertension and organ transplant. LifeCycle Pharma is listed on the OMX Nordic Exchange under the trading symbol (LCP). Please visit www.lcpharma.com for further information about LifeCycle Pharma A/S.