TopoTarget A/S Symbion Fruebjergvej 3 DK 2100 Copenhagen Denmark Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com To the Copenhagen Stock Exchange Announcement No. 23-07 / Copenhagen 26 June 2007 Report pursuant to the Danish Securities Trading Act, Section 28a Copenhagen - 26 June 2007 - Pursuant to the Danish Securities Trading Act, Section 28a TopoTarget A/S (Copenhagen Stock Exchange: TOPO) is obliged to report on transactions by members of its senior management and their related parties in shares issued by TopoTarget A/S and related securities. Name Peter Buhl Jensen Reason CEO Issuer and ISIN code TopoTarget A/S, DK0060086072 Transaction Purchase Trade date 25 June 2007 Market Copenhagen Stock Exchange Number 10,010 Market value in DKK 300,300 Name Leif Hamø Reason CFO Issuer and ISIN code TopoTarget A/S, DK0060086072 Transaction Purchase Trade date 25 June 2007 Market Copenhagen Stock Exchange Number 26,677 Market value in DKK 800,310 TopoTarget A/S For further information, please contact: Dr. Peter Buhl Jensen Telephone +45 39 17 83 41 Chief Executive Officer Mobile +45 21 60 89 22 Background information About TopoTarget TopoTarget (OMX - The Nordic Exchange: TOPO) is a biopharmaceutical company, headquartered in Denmark and with subsidiaries in the UK, Germany and the USA, dedicated to finding ''Answers for Cancer'' and developing improved cancer therapies. TopoTarget is founded and run by clinical cancer specialists and combines years of hands-on clinical experience with in-depth understanding of the molecular mechanisms of cancer. Focus lies on highly predictive cancer models and key cancer enzyme regula-tors (mainly HDAC, mTOR, and topoisomerase II inhibitors) and a strong development foundation has been built. TopoTarget has a broad portfolio of small molecule preclini-cal drug candidates and seven drugs are in clinical development, including both novel anti-cancer therapeutics and new cancer indications for existing drugs. Savene™ is TopoTarget's first product on the market. In addition to organic growth, TopoTarget consistently looks for opportunities to strengthen and expand its activities through acquisitions and in-licensing. For more information, please refer to www.topotarget.com.