NeuroSearch's development and license partner Abbott has enrolled and dosed the first patients in a clinical Phase I study with the drug candidate ABT-560, which has treatment potential within a variety of CNS disorders. ABT-560 is a neuronal nicotinic receptor (NNR) modulator, which has shown promise in preclinical models relevant for the treatment of cognitive deficits. According to the terms of the license agreement, Abbott has all rights to ABT-560 and will finance all costs relating to the development and commercialisation of the drug. NeuroSearch will receive milestone payments as well as royalties on Abbott's global sales, if the drug is successfully commercialised. The initiation of the Phase I study with ABT-560 releases a milestone payment to NeuroSearch. NeuroSearch maintains financial expectations for 2007 of a loss before recognition of associates and other equity interests in the region of DKK 80 - 100 million. Asger Aamund Chairman of the Board Contact persons: Phone: Hanne Leth Hillman, Vice President, Director of Investor Relations & Corporate Communications +45 4460 8212 or +45 4017 5103 NeuroSearch (NEUR) is a Scandinavian biopharmaceutical company listed on the Nordic Exchange Copenhagen A/S. Our core business covers the development of novel drugs, based on a broad and well-established drug discovery platform focusing on ion channels and CNS disorders. A substantial part of the company's activities are partner financed through a broad alliance with GlaxoSmithKline (GSK) and collaborations with among others Abbott and Astellas. The drug pipeline comprises 11 clinical development programmes: ACR16 in Huntington's disease (Phase III preparation), tesofensine in obesity/type 2 diabetes (Phase II), NS2359 in depression (Phase II) and ADHD (Phase II) in partnership with GSK, NS1209 in epilepsy and pain (Phase II), ABT-894 in ADHD (Phase II) and pain (Phase I) in partnership with Abbott, ACR16 in schizophrenia (Phase I) in partnership with Astellas, ACR325 in bipolar disorder (Phase I) and ABT-107 as well as ABT-560 for the treatment of various CNS diseases - both (Phase I) in collaboration with Abbott. In addition, NeuroSearch has a broad portfolio of preclinical drug candidates and holds equity interests in several biotech companies.
NeuroSearch's license partner Abbott initiates clinical Phase I study with ABT-560
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