Phase I Results Announced for R1507 from Genmab's Collaboration with Roche


Summary:  Roche releases positive Phase I results for R1507.                    

Copenhagen, Denmark; October 23, 2007 - Genmab A/S (OMX: GEN) announced today   
positive results from a Phase I study of R1507 in patients with solid tumors,   
conducted by its partner Roche. R1507 is a human monoclonal antibody targeting  
the insulin-like growth factor receptor (IGF-1R) and was developed under Roche's
collaboration with Genmab.                                                      

Nine of 34 adult patients with solid tumors experienced disease stabilization   
when treated with R1507.  Four of the seven heavily pretreated patients with    
Ewing's sarcoma demonstrated clinical benefit with two of these patients        
achieving durable, objective partial responses.                                 

Once a week administration of R1507 was well tolerated with few side effects.   
The most frequently observed side effects were fatigue, anorexia and weight     
loss, symptoms that are commonly observed in patients with advanced cancer.  A  
similar side effect profile was seen in 26 patients who were treated with R1507 
on a three week schedule.                                                       

The results were reported during the AACR-NCI-EORTC International Conference on 
Molecular Targets and Cancer Therapeutics in San Francisco, California, USA.    
Further details can be found at http://www.rocheusa.com.                        

“These are the first clinical results to be presented from an antibody developed
by Genmab under our collaboration with Roche,” said Lisa N. Drakeman, Ph.D.  “We
are pleased with these positive results and hope it may offer a potential       
treatment for sarcoma patients in the future.”                                  

Based on these initial results with R1507, Roche plans to conduct additional    
trials and work with a global consortium of sarcoma experts, including the      
Sarcoma Alliance for Research through Collaboration (SARC).                     

About IGF-1R                                                                    
IGF-1 is one of the most potent natural activators of the AKT and MAPK signaling
pathways, which promote cell growth and cell survival.  The IGF-1R pathway has  
also been shown to have an important role in mediating the resistance to        
cytotoxic drugs and EGFR/HER2-targeted agents.  The IGF-1R molecule has been    
shown to be important in tumor growth and protecting tumor cells from being     
killed.  IGF-1R is over-expressed on a variety of tumors including breast,      
colon, prostate, lung, skin and pancreatic cancers and is a well validated      
target for an antibody therapeutic approach.                                    

About Ewing's Sarcoma                                                           
The Ewing's family of tumors (EFT) includes primary tumors of bone (classic     
Ewing's sarcoma, primitive neuroectodermal tumor, and Askin tumor) and          
extraosseous primary tumors.  The estimated incidence of Ewing's sarcoma in the 
US is approximately 300 new cases per year.  More than 50 percent of patients   
are adolescents with a slight predominance in males.  Patients who present with 
metastatic disease at initial diagnosis have a survival rate of approximately 25
to 30%.  
                                                                       
About Genmab A/S                                                                
Genmab is a leading international biotechnology company focused on developing   
fully human antibody therapeutics for unmet medical needs.  Using unique,       
cutting-edge antibody technology, Genmab's world class discovery and development
teams have created and developed an extensive pipeline of products for potential
treatment of a variety of diseases including cancer and autoimmune disorders.   
As Genmab advances towards a commercial future, we remain committed to our      
primary goal of improving the lives of patients who are in urgent need of new   
treatment options.  For more information on Genmab's products and technology,   
visit www.genmab.com.                                                           

This press release contains forward looking statements. The words “believe”,    
“expect”, “anticipate”, “intend” and “plan” and similar expressions identify    
forward looking statements. Actual results or performance may differ materially 
from any future results or performance expressed or implied by such statements. 
The important factors that could cause our actual results or performance to     
differ materially include, among others, risks associated with product discovery
and development, uncertainties related to the outcome and conduct of clinical   
trials including unforeseen safety issues, uncertainties related to product     
manufacturing, the lack of market acceptance of our products, our inability to  
manage growth, the competitive environment in relation to our business area and 
markets, our inability to attract and retain suitably qualified personnel, the  
unenforceability or lack of protection of our patents and proprietary rights,   
our relationships with affiliated entities, changes and developments in         
technology which may render our products obsolete, and other factors. Genmab is 
not under an obligation to up-date statements regarding the future following the
publication of this release; nor to confirm such statements in relation to      
actual results, unless this is required by law.                                 

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Contact: Helle Husted, Sr. Director, Investor Relations, T: +45 33 44 77 30, M: 
+45 25 27 47 13, E: hth@genmab.com                                              
                                                                                
Stock Exchange Release no. 49/2007                                              

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49 r1507 ph i results_231007_uk.pdf