Express Scripts Reports a 43 Percent Increase in Adjusted Earnings Per Share




  2007 Earnings Per Share Guidance Increased -- Midpoint Reflects 39
                             Percent Growth

   Record Third Quarter Cash Flow From Operations of $247 million

ST. LOUIS, Oct. 24, 2007 (PRIME NEWSWIRE) -- Express Scripts, Inc. (Nasdaq:ESRX) announced third quarter net income of $142.9 million, or $0.56 per diluted share, which includes non-recurring charges totaling $0.04 per diluted share discussed below. Excluding these charges, diluted earnings per share was $0.60, a 43 percent increase over $0.42 per diluted share for the same quarter last year. All per share amounts have been adjusted to reflect the Company's 2-for-1 stock split, which was effective June 22, 2007.

The Company reported cash flow from operations of $247.0 million in the third quarter compared to $158.8 million for the same period last year. During the quarter, Express Scripts repurchased 6.1 million shares of common stock for $313.6 million, and year to date, the Company has repurchased 23.1 million shares for $1,140.3 million.

"Our outstanding results demonstrate the power of aligning interests with plan sponsors and patients, which continues to fuel our success," stated George Paz, president, chief executive officer and chairman. "Our industry-leading generic utilization rate reached a record 62.2 percent this quarter, and demonstrates the success of our business model."

"We are entering the next stage of alignment: enabling better health and value at the consumer level. By unlocking value one member at a time, we are generating increased savings for our clients through lower-cost drugs and channels, and better health outcomes through improved therapy adherence. As we deliver savings for our clients, we deliver stronger performance for our stockholders."

Third Quarter Review

Total adjusted claims for the quarter were 123.9 million. Retail network claims processed in the third quarter were 92.1 million, home delivery claims were 10.2 million, and Specialty and Ancillary Services ("SAAS") claims were 1.2 million.

Gross profit for the third quarter increased 19 percent to $444.5 million from $374.3 million last year. The increase reflects higher generic utilization and lower retail and home delivery drug purchasing costs. Gross profit per adjusted claim was a record $3.59, a 20 percent increase over $2.99 for the same quarter last year.

During the third quarter, the Company recorded non-recurring charges of $18.5 million ($11.4 million net of tax), or $0.04 per diluted share in the SAAS segment, the majority of which pertained to a charge to bad debt expense resulting from the insolvency of a specialty distribution client. Adjusted operating income, excluding these non-recurring charges, increased 36 percent to $279.1 million from $205.7 million last year.

Adjusted operating income for the SAAS segment decreased $1.3 million sequentially from $10.5 million in the second quarter to $9.2 million in the third quarter due to the infusion line of business. The infusion line of business had an operating loss of $6.8 million for the quarter and $12.5 million for 9 months ended September 30, 2007. The Company recently announced plans to close 6 under-performing infusion sites and reduce overhead to improve the operating performance of this line of business. Concurrent with these changes, Express Scripts will evaluate the strategic fit of the infusion business in the Company's product portfolio.

Operating income for the PBM segment increased 39 percent to $269.9 million from $194.0 million last year reflecting higher generic utilization and lower retail and home delivery drug purchasing costs. These same factors translated into strong EBITDA growth. Adjusted EBITDA increased 32 percent to $302.3 million from $229.5 million last year and reached a record $2.44 per adjusted claim, a 33 percent increase over $1.84 last year.

2007 Earnings Guidance

As a result of the strong underlying trends in the overall business, the Company is raising its previous 2007 diluted earnings per share guidance from a range of $2.23 to $2.29 to a range of $2.28 to $2.32. This guidance range excludes the non-recurring items identified in Tables 3 and 4 below. In addition, cash flow from operations is expected to be in the upper half of the previous guidance range of $750 million to $850 million.

Express Scripts, Inc. is one of the largest PBM companies in North America, providing PBM services to over 50 million members through thousands of client groups, including managed-care organizations, insurance carriers, employers, third-party administrators, public sector, workers compensation, and union-sponsored benefit plans.

Express Scripts provides integrated PBM services, including network-pharmacy claims processing, home delivery services, benefit-design consultation, drug-utilization review, formulary management, disease management, and medical- and drug-data analysis services. The Company also distributes a full range of injectable and infusion biopharmaceutical products directly to patients or their physicians, and provides extensive cost-management and patient-care services.

Express Scripts is headquartered in St. Louis, Missouri. More information can be found at http://www.express-scripts.com, which includes expanded investor information and resources.

SAFE HARBOR STATEMENT

This press release contains forward-looking statements, including, but not limited to, statements related to the Company's plans, objectives, expectations (financial and otherwise) or intentions. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Factors that may impact these forward-looking statements include but are not limited to:



  * uncertainties associated with our acquisitions, which include
    integration risks and costs, uncertainties associated with client
    retention and repricing of client contracts, and uncertainties
    associated with the operations of acquired businesses
  * costs and uncertainties of adverse results in litigation,
    including a number of pending class action cases that challenge
    certain of our business practices
  * investigations of certain PBM practices and pharmaceutical
    pricing, marketing and distribution practices currently being
    conducted by various regulatory agencies  and state attorneys
    general
  * changes in industry pricing benchmarks such as average wholesale
    price ("AWP") and average manufacturer price ("AMP"), which could
    have the effect of reducing prices and margins
  * increased compliance risk relating to our contracts with the DoD
    TRICARE Management Activity and various state governments and
    agencies
  * results in regulatory matters, the adoption of new legislation or
    regulations (including increased costs associated with compliance
    with new laws and regulations), more aggressive enforcement of
    existing legislation or regulations, or a change in the
    interpretation of existing legislation or regulations
  * uncertainties regarding the Medicare Part D prescription drug
    benefit, including the financial impact  to us to the extent that
    we participate in the program on a risk-bearing basis,
    uncertainties of client or member losses to other providers under
    Medicare Part D, and increased regulatory risk
  * the possible loss, or adverse modification of the terms, of
    contracts with pharmacies in our retail pharmacy network
  * competition in the PBM and specialty pharmacy industries, and our
    ability to consummate contract negotiations with prospective
    clients, as well as competition from new competitors offering
    services that may in whole or in part replace services that we now
    provide to our customers
  * our ability to continue to develop new products, services and
    delivery channels
  * our ability to maintain growth rates, or to control operating or
    capital costs
  * uncertainties associated with U.S. Centers for Medicare &
    Medicaid's ("CMS") implementation of the Medicare Part B
    Competitive Acquisition Program ("CAP"), including the potential
    loss of clients/revenues to providers choosing to participate in
    the CAP
  * continued pressure on margins resulting from client demands for
    lower prices, enhanced service offerings and/or higher service
    levels, and the possible termination of, or unfavorable
    modification to, contracts with key clients or providers
  * the possible loss, or adverse modification of the terms, of
    relationships with pharmaceutical manufacturers, or changes in
    pricing, discount or other practices of pharmaceutical
    manufacturers or interruption of the supply of any pharmaceutical
    products
  * the use and protection of the intellectual property we use in our
    business
  * our leverage and debt service obligations, including the effect of
    certain covenants in our borrowing agreements
  * general developments in the health care industry, including the
    impact of increases in health care costs, changes in drug
    utilization and cost patterns and introductions of new drugs
  * increase in credit risk relative to our clients due to adverse
    economic trends or other factors
  * our ability to attract and retain qualified employees
  * other risks described from time to time in our filings with the
    SEC

We do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



                                EXPRESS SCRIPTS, INC.
                     Unaudited Consolidated Statement of Operations

                           Three months ended     Nine months ended
                              September 30,         September 30,
 (in millions, except     --------------------  --------------------
  per share data)           2007       2006       2007       2006
                          ---------  ---------  ---------  ---------

 Revenues (a)             $ 4,519.0  $ 4,330.2  $13,658.9  $13,131.3
 Cost of revenues (a)       4,074.5    3,955.9   12,344.9   12,048.8
                          ---------  ---------  ---------  ---------
  Gross profit                444.5      374.3    1,314.0    1,082.5
 Selling, general and
  administrative              183.9      168.6      539.7      500.8
                          ---------  ---------  ---------  ---------
 Operating income             260.6      205.7      774.3      581.7
                          ---------  ---------  ---------  ---------
 Other (expense) income :
  Non-operating gains
  (charges), net                0.2         --      (18.6)        --
  Undistributed loss
   from joint venture          (0.3)      (0.4)      (1.1)      (1.2)
  Interest income               2.7        2.3        8.1       11.3
  Interest expense            (31.3)     (26.4)     (79.1)     (70.6)
                          ---------  ---------  ---------  ---------
                              (28.7)     (24.5)     (90.7)     (60.5)
                          ---------  ---------  ---------  ---------
 Income before income
  taxes                       231.9      181.2      683.6      521.2
 Provision for income
  taxes                        89.0       66.5      254.3      194.0
                          ---------  ---------  ---------  ---------
 Net income               $   142.9  $   114.7  $   429.3  $   327.2
                          =========  =========  =========  =========

 Basic earnings per
  share ("EPS"):          $    0.56  $    0.42  $    1.63  $    1.16
                          =========  =========  =========  =========
 Weighted average number
  of common shares
  outstanding during the
  period - Basic EPS          254.2      272.2      263.1      282.4
                          =========  =========  =========  =========

 Diluted earnings per
  share                   $    0.56  $    0.42  $    1.61  $    1.14
                          =========  =========  =========  =========
 Weighted average number
  of common shares
  outstanding during the
  period - Diluted EPS        257.3      276.4      266.3      287.0
                          =========  =========  =========  =========


 (1) Excludes estimated retail pharmacy co-payments of $909.4 million
     and $942.8 million for the three months ended September 30, 2007
     and 2006, respectively and $2,841.5 million and $3,209.2 million
     for the nine months ended September 30, 2007 and 2006,
     respectively. These are amounts we instructed retail pharmacies
     to collect from members. We have no information regarding actual
     co-payments collected.


                   EXPRESS SCRIPTS, INC.
           Unaudited Consolidated Balance Sheet


                                            September 30, December 31,
 (in millions, except share data)                2007        2006
                                              ----------  ----------
  Assets
  Current assets:
   Cash and cash equivalents                  $     96.0  $    131.0
   Receivables, net                              1,308.4     1,334.4
   Inventories                                     158.8       194.6
   Deferred taxes                                  113.3        90.9
   Prepaid expenses and other current assets        19.6        21.2
                                              ----------  ----------
    Total current assets                         1,696.1     1,772.1
  Property and equipment, net                      203.9       201.4
  Goodwill                                       2,689.5     2,686.0
  Other intangible assets, net                     350.9       378.4
  Other assets                                      43.6        70.2
                                              ----------  ----------
    Total assets                              $  4,984.0  $  5,108.1
                                              ==========  ==========

  Liabilities and Stockholders' Equity
  Current liabilities:
   Claims and rebates payable                 $  1,203.8  $  1,275.7
   Accounts payable                                547.2       583.4
   Accrued expenses                                401.2       390.2
   Current maturities of long-term debt            240.1       180.1
                                              ----------  ----------
    Total current liabilities                    2,392.3     2,429.4
  Long-term debt                                 1,740.3     1,270.4
  Other liabilities                                314.0       283.4
                                              ----------  ----------
    Total liabilities                            4,446.6     3,983.2
                                              ----------  ----------

  Stockholders' Equity:
   Preferred stock, 5,000,000 shares
    authorized, $0.01 par value per share;
    and no shares issued and outstanding              --          --
   Common stock, 1,300,000,000 shares
    authorized, $0.01 par value per share;
    shares issued: 318,875,000 and
    159,442,000, respectively; shares
    outstanding: 252,044,000 and 135,650,000,
    respectively                                     3.2         1.6
  Additional paid-in capital                       550.4       495.3
  Accumulated other comprehensive income            19.4        11.9
  Retained earnings                              2,446.4     2,017.3
                                              ----------  ----------
                                                 3,019.4     2,526.1
  Common stock in treasury at cost, 66,831,000
   and 23,792,000 shares, respectively          (2,482.0)   (1,401.2)
                                              ----------  ----------
     Total stockholders' equity                    537.4     1,124.9
                                              ----------  ----------
     Total liabilities and stockholders'
      equity                                  $  4,984.0  $  5,108.1
                                              ==========  ==========


                        EXPRESS SCRIPTS, INC.
       Unaudited Condensed Consolidated Statement of Cash Flows


                                                 Nine months ended
                                                    September 30,
                                               ----------------------
 (in millions)                                    2007        2006
                                               ----------  ----------

 Cash flow from operating activities:
 Net income                                    $    429.3  $    327.2
 Adjustments to reconcile net income to net
  cash provided by operating activities:
   Depreciation and amortization                     75.3        75.7
   Non-cash adjustments to net income                52.3        44.4
   Changes in operating assets and
    liabilities:
    Claims and rebates payable                      (72.0)     (178.8)
    Other net changes in operating assets and
     liabilities                                     13.4        84.1
                                               ----------  ----------
 Net cash provided by operating activities          498.3       352.6
                                               ----------  ----------

 Cash flows from investing activities:
  Purchases of property and equipment               (49.5)      (38.2)
  Sale of marketable securities                      34.2          --
  Other                                              (0.6)        0.1
                                               ----------  ----------
 Net cash used in investing activities              (15.9)      (38.1)
                                               ----------  ----------

 Cash flows from financing activities:
  Proceeds from long-term debt                      700.0          --
  Repayment of long-term debt                      (120.1)      (80.1)
  (Repayment of) proceeds from revolving
   credit line, net                                 (50.0)      200.0
  Tax benefit relating to employee stock
   compensation                                      43.7        33.0
  Treasury stock acquired                        (1,140.3)     (906.8)
  Net proceeds from employee stock plans             47.1        28.8
  Deferred financing fees                            (1.3)       (0.3)
                                               ----------  ----------
 Net cash used in financing activities             (520.9)     (725.4)
                                               ----------  ----------

 Effect of foreign currency translation
  adjustment                                          3.5         1.1
                                               ----------  ----------

 Net decrease in cash and cash equivalents          (35.0)     (409.8)
 Cash and cash equivalents at beginning of
  period                                            131.0       477.9
                                               ----------  ----------
 Cash and cash equivalents at end of period    $     96.0  $     68.1
                                               ==========  ==========


                              EXPRESS SCRIPTS, INC.
           (in millions, except per claim, per share and ratio data)
                                    Table 1
                        Unaudited Operating Statistics
  --------------------------------------------------------------------
                    3 months  3 months  3 months   3 months  3 months
                      ended     ended     ended      ended     ended
                    9/30/2007 6/30/2007 3/31/2007 12/31/2006 9/30/2006
                    --------- --------- --------- ---------- ---------

  Revenues
  PBM                 3,612.4  3,669.3   3,608.9   3,626.3   3,465.1
  SAAS                  906.6    931.1     930.6     902.4     865.1
                     -------- --------  -------- --------- ---------
    Total
     consolidated
     revenues         4,519.0  4,600.4   4,539.5   4,528.7   4,330.2
                     ======== ========  ========  ========  ========

  Claims Detail
  Network (1)            92.1     94.1      96.8      97.8      93.2
  Home delivery          10.2     10.2      10.0      10.3      10.2
                     -------- --------  -------- --------- ---------
   Total PBM claims     102.3    104.3     106.8     108.1     103.4
                     -------- --------  -------- --------- ---------
   Adjusted PBM claims
   (2)                  122.7    124.8     126.8     128.7     123.8
                     ======== ========  ========  ========  ========
  SAAS claims (3)         1.2      1.2       1.2       1.3       1.3
                     -------- --------  -------- --------- ---------
   Total adjusted
    claims (4)          123.9    126.0     128.0     130.0     125.1
                     ======== ========  ========  ========  ========

  Per Adjusted Claim
  Adjusted Gross
   profit            $   3.59 $   3.52  $   3.26  $   3.19  $   2.99
  Adjusted EBITDA    $   2.44 $   2.27  $   2.11  $   2.06  $   1.84
  --------------------------------------------------------------------

                    Selected Ratio Analysis
                            Table 2

 ---------------------------------------------------------------------
                  As of      As of      As of      As of       As of
                9/30/2007  6/30/2007  3/31/2007  12/31/2006  9/30/2006
                ---------  ---------  ---------  ----------  ---------

 Debt to EBITDA
  ratio (6)          1.8x       1.8x       1.4x        1.6x       1.9x
 EBITDA interest
  coverage (7)      10.7x      10.7x      10.2x        9.7x       9.4x
 Operating cash
  flow interest
  coverage (8)       7.7x       7.2x       7.9x        6.9x       6.6x
 Debt to
  capitalization
  (9)               78.7%      73.6%      51.4%       56.3%      62.7%
 ---------------------------------------------------------------------
 See Notes to Unaudited Operating Statistics and Selected Ratio
  Analysis

             Unaudited Earnings Excluding Non-recurring Items
                                  Table 3
 ---------------------------------------------------------------------
                             3 months   3 months   9 months   9 months
                              ended      ended      ended      ended
                            9/30/2007  9/30/2006  9/30/2007  9/30/2006
                            ---------  ---------  ---------  ---------
 Reported income before
  taxes                     $   231.9  $   181.2  $   683.6  $   521.2
  Transaction costs for
   terminated proposal
   to acquire Caremark,
   less special dividend
   received on Caremark
   stock and gain on
   sale of Caremark stock        (0.2)        --       18.6         --
  Settlement of contractual
   item with supply chain
   vendor                          --         --       (9.0)        --
  Non-recurring items,
   majority of which relates
   to bad debt charge in
   specialty distribution
   line of business              18.5         --       18.5         --
                            ---------  ---------  ---------  ---------
 Income before taxes
  excluding net non-
  recurring charges             250.2      181.2      711.7      521.2

 Adjusted provision for
  income taxes                   96.0       66.5      264.8      194.0
                            ---------  ---------  ---------  ---------

 Net income excluding net
  non-recurring charges     $   154.2  $   114.7  $   446.9  $   327.2
                            =========  =========  =========  =========
 Weighted average number of
  shares outstanding during
  period - diluted              257.3      276.4      266.3      287.0

 Diluted earnings per share
  excluding net charges     $    0.60  $    0.42 $     1.68  $    1.14

 Diluted earnings per share
  as reported                    0.56       0.42       1.61       1.14
                            ---------  ---------  ---------  ---------

 Impact of non-recurring
  items                     $   (0.04) $      --  $   (0.07) $      --
 ---------------------------------------------------------------------
 The Company is providing diluted earnings per share excluding the
 impact of certain charges in order to compare the underlying
 financial performance to prior periods.


       Earnings Guidance Forecast Excluding Non-recurring Items
                                Table 4
 ---------------------------------------------------------------------

                                             For the year ended
                                              December 31, 2007
                                            --------------------
 Earnings guidance range, including
  net non-recurring charges                 $  2.21  to  $  2.25

 Impact of non-recurring items per
  Table 3                                      0.07         0.07
                                            -------      -------
 Earnings guidance range, excluding
  net non-recurring charges                 $  2.28  to  $  2.32
                                            =======      ========
 ---------------------------------------------------------------------

 ---------------------------------------------------------------------
         Calculation of Adjusted Operating Income and EBITDA
                                 Table 5
                                              3 months    9 months
                                                ended       ended
                                              9/30/2007   9/30/2007
                                              ---------   ---------
 Operating Income, as reported                $   260.6   $   774.3
 Settlement of contractual item with supply
  chain vendor                                       --        (9.0)
 Non-recurring items, majority of which
  relates to bad debt charge in specialty
  distribution line of business                    18.5        18.5
                                              ---------   ---------
 Adjusted Operating Income                    $   279.1   $   783.8
                                              =========   =========

 EBITDA, as reported (5)                      $   283.8   $   849.6
 Settlement of contractual item with supply
  chain vendor                                       --        (9.0)
 Non-recurring items, majority of which
  relates to bad debt charge in specialty
  distribution line of business                    18.5        18.5
                                              ---------   ---------
 Adjusted EBITDA                              $   302.3   $   859.1
                                              =========   =========

 The Company is providing adjusted operating income and
  EBITDA excluding the impact of non-recurring charges in order to
  compare the underlying financial performance to prior periods.
 ---------------------------------------------------------------------


                      EXPRESS SCRIPTS, INC.

 Notes to Unaudited Operating Statistics and Selected Ratio Analysis
                        (in millions)


 (1) Network claims exclude drug formulary only claims where we only
     administer the clients formulary and approximately 0.5 million
     manual claims per quarter.

 (2) PBM adjusted claims represent network claims plus mail claims,
     which are multiplied by 3, as mail claims are typically 90 day
     claims and network claims are generally 30 day claims. Adjusted
     claims calculated from the table may differ due to rounding.

 (3) Specialty and Ancillary Services (SAAS) claims represent the
     distribution of pharmaceuticals through Patient Assistance
     Programs and the distribution of pharmaceuticals where we have
     been selected by the pharmaceutical manufacturer as part of a
     limited distribution network. They also represent the
     distribution of specialty drugs through our CuraScript
     subsidiary.

 (4) Total adjusted claims includes PBM adjusted claims plus SAAS
     claims.

 (5) The following is a reconciliation of EBITDA to net income and to
     net cash provided by operating activities as the Company
     believes they are the most directly comparable measures
     calculated under Generally Accepted Accounting Principles:


                                 3 months ended      9 months ended
                                  September 30,       September 30,
                               ------------------  ------------------
                                 2007      2006      2007      2006
                               --------  --------  --------  --------
 Net income                    $  142.9  $  114.7  $  429.3  $  327.2
  Income taxes                     89.0      66.5     254.3     194.0
  Depreciation and
   amortization *                  23.2      23.8      75.3      75.7
  Interest expense, net            28.6      24.1      71.0      59.3
  Undistributed loss from joint
   venture                          0.3       0.4       1.1       1.2
  Non-operating charges, net       (0.2)       --      18.6        --
                               --------  --------  --------  --------
 EBITDA                           283.8     229.5     849.6     657.4
  Current income taxes            (90.5)    (50.3)   (261.4)   (183.2)
  Interest expense less
   amortization                   (28.0)    (23.6)    (69.4)    (57.8)
  Undistributed loss from
   joint venture                   (0.3)     (0.4)     (1.1)     (1.2)
  Non-operating charges, net        0.2        --     (18.6)       --
  Other adjustments to
   reconcile net income to net
   cash provided by operating
   activities                      81.8       3.6      (0.8)    (62.6)
                               --------  --------  --------  --------
 Net cash provided by
  operating activities         $  247.0  $  158.8  $  498.3  $  352.6
                               ========  ========  ========  ========

 EBITDA is earnings before other income (expense), interest, taxes,
 depreciation and amortization, or operating income plus depreciation
 and amortization. EBITDA is presented because it is a widely
 accepted indicator of a company's ability to service indebtedness
 and is frequently used to evaluate a company's performance. EBITDA,
 however, should not be considered as an alternative to net income,
 as a measure of operating performance, as an alternative to cash
 flow, as a measure of liquidity or as a substitute for any other
 measure computed in accordance with accounting principles generally
 accepted in the United States. In addition, our definition and
 calculation of EBITDA may not be comparable to that used by other
 companies.


 * Includes depreciation and
    amortization expense of:

     Gross profit                   6.6       8.6      24.4      26.9
     Selling, general and
      administrative               16.6      15.2      50.9      48.8
                               --------  --------  --------  --------
                                   23.2      23.8      75.3      75.7
                               ========  ========  ========  ========

 (6) Represents debt as of the balance sheet date divided by EBITDA
     for the twelve months ended.

 (7) Represents EBITDA for the twelve months ended divided by
     interest expense for the twelve months ended.

 (8) Represents Operating Cash Flow for the twelve months ended
     divided by interest expense for the twelve months ended.

 (9) Represents debt divided by the total of debt and stockholders
     equity.


            

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