Shire plc (SHPGY) Chief Executive Officer and Chief Financial Officer to Ring the NASDAQ Stock Market Opening Bell


ADVISORY, Nov. 1, 2007 (PRIME NEWSWIRE) --



 What:
 Matthew Emmens, Chief Executive Officer and Angus Russell, Chief
 Financial Officer of Shire plc (SHPGY), will preside over the
 opening bell.

 Where:
 NASDAQ MarketSite - 4 Times Square - 43rd & Broadway - Broadcast Studio

 When:
 Friday, November 2, 2007 at 9:30 a.m. ET

 Contacts:
 Matt Cabrey
 484-595-8248; mcabrey@shire.com

 NASDAQ MarketSite:
 Jolene Libretto; 646.441.5220; mobile - 347.219.9539
 Jolene.Libretto@NASDAQ.com

Feed Information:

The opening bell is available from 9:20 a.m. to 9:35 a.m. on Galaxy 26 - uplink IA6 C band / transponder 24, downlink frequency 4180 horizontal. The feed can also be found on Waterfront fiber 1623. If you have any questions, please contact Jolene Libretto at (646) 441-5220.

Radio Feed:

An audio transmission of the opening bell is also available from 9:20 a.m. to 9:35 a.m. on uplink IA6 C band / transponder 24, downlink frequency 4180 horizontal. The feed can be found on Waterfront fiber 1623 as well.

Webcast:

A live webcast of the NASDAQ Opening Bell will be available at: http://www.nasdaq.com/reference/marketsite_about.stm.

Photos:

To obtain a hi-resolution photograph of the Market Open, please go to http://www.nasdaq.com/reference/marketsite_events.stm and click on the market open of your choice.

About Shire plc (SHPGY):

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the U.S. or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.