Cheshire, UK--(Marketwire - November 19, 2007) -

                            Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 19 November 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that on 16 November 2007, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies ("AXA"). The notification follows an increase in the Indirect holding of AXA. Details of the interest notified are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

A acquisition of voting rights                                         x
An acquisition or disposal of financial instruments which may result in
the acquisition of shares already issued to which voting rights are
An event changing the breakdown of voting rights
Other (please specify):

2. Full name of person(s) subject to the    AXA S.A., 25 Avenue Matignon,
   notification obligation:                 75008 Paris and its
                                            group of companies.

3. Full name of shareholder(s) (if different
   from 2.):

4. Date of the transaction (and date on which     15 November 2007
   the threshold is crossed or reached if

5. Date on which issuer notified:                 16 November 2007

6. Threshold(s) that is/are crossed or   
   reached:                                       12%

7. Notified details:

A: Voting rights attached to shares

Class/type of     Situation previous to    Resulting situation after the
shares            the Triggering           triggering transaction

if possible using Number of   Number of   Number of       Number of
the ISIN CODE     Shares      of voting   shares        voting rights
                              Rights      Direct      Direct   Indirect
0702920           41,452,836  41,452,836  741,666     741,666  41,034,072 

% of voting rights
Direct    Indirect
0.22%     12.09%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Exercise/ Conversion   Number of             % of
instrument           Period/ Date           voting rights         voting
                                            that may be acquired  rights
           Expiration                       if the instrument
             date                           is exercised/ 

Total (A+B)
Number of voting rights                           % of voting rights
41,775,738                                        12.31%

8. Chain of controlled undertakings through which the voting rights
   and/or the financial instruments are effectively held, if applicable:

Name of Company/Fund                     Number            % of issued
                                      of Shares           share capital 
AXA UK Investment Co ICVC               538,641                 0.15873
UK Smaller Companies Fund

Sun Life Pensions Management Ltd         25,000                 0.00737

AXA Sun Life                             53,913                 0.01589
FTSE All Share Tracker Life

AXA Sun Life                            294,874                 0.08689
FTSE All Share Tracker Pension

AXA Framlington                         750,000                 0.22101
SEI UK Equity

AXA Framlington                         972,006                 0.28643
St James Place Exempt (Pens) Fund

AXA Framlington                       1,093,505                 0.32224
St James Place Net (Life) Fund

AXA Framlington                         243,001                 0.07161
St James Place Offshore Fund

AXA Framlington                         364,502                 0.10741
Daimler Chrysler

AXA Framlington                       3,120,333                 0.91951
Throgmorton Trust

AXA Framlington                      15,013,453                 4.42422
UK Selet Ops

AXA Framlington                      13,753,131                 4.05282
Equity Income

AXA Framlington                       2,000,000                 0.58937
Managed Balanced

AXA Framlington                       1,500,000                 0.44203
UK Smaller Companies

AXA Framlington                         500,000                 0.14734
BAE Systems Pensions Fund CIF Trustees

AXA Framlington                         220,000                 0.06483
BAE Systems 2000 Pensions Fund

AXA Framlington onshore private clients 850,500                 0.25063

AXA Framlington                         115,000                 0.03389
St James Place Internal Equity & Income UT

Axa Sun Life with Profits Passive       226,817                 0.06684

Sun Life Ass Soc with Profits Passive   141,062                 0.04157

                   Total Direct         741,666                 0.21856

                   Total Indirect    41,034,072                12.09207

                   TOTAL             41,775,738                12.31063

Proxy Voting:

9.  Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting

12. Additional information:

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs         +44 (0) 7919  480510
Julie Vickers, Company Secretary                    +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                       +44 (0) 20 7831 3113
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