Patient Enrollment Completed in Phase IIb Trial of EpiCept(TM) NP-1 in Diabetic Peripheral Neuropathy


Patient Enrollment Completed in Phase IIb Trial of EpiCept(TM) NP-1 in Diabetic 
                             Peripheral Neuropathy                              

                      Top-line data expected in early 2008                      

TARRYTOWN, N.Y., Dec. 3 /PRNewswire / -- EpiCept Corporation (Nasdaq and OMX    
Nordic Exchange: EPCT) today announced that it has completed patient enrollment 
in the Phase IIb "Neuracept" trial for EpiCept(TM) NP-1 cream.  EpiCept NP-1 is 
a patented topical cream formulation of two FDA-approved drugs, 4% amitriptyline
and 2% ketamine, and is intended to provide long-term relief from the pain of   
peripheral neuropathies.                                                        
    (Logo: http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO )            
This Phase IIb trial compares the active ingredients in NP-1 against placebo in 
patients suffering from diabetic peripheral neuropathy (DPN), the most common   
form of neuropathic pain.  Only two medications are currently available in the  
United States for the treatment of DPN. The four-week, 200-patient trial is     
intended to confirm and expand upon earlier work that provided a preliminary    
efficacy signal in this type of neuropathic pain.  The primary endpoint for the 
Phase IIb trial is the difference between active and placebo changes in pain    
intensity from baseline compared to the average over the last seven days of     
treatment.                                                                      
"We are pleased to have reached another key clinical milestone that we          
established for 2007, and to have advanced another one of our product           
candidates," stated Jack Talley, President and Chief Executive Officer of       
EpiCept. "We believe NP-1 holds the largest market potential of the pain        
candidates in our portfolio.  Treatment of neuropathic pain is a billion dollar 
opportunity.  We believe that NP-1 has the potential to become a new and        
efficacious topical treatment without the inherent systemic side effects of     
alternative treatments for the 15 million Americans who suffer from peripheral  
neuropathies.  We expect to report top-line results from this trial in early    
2008."                                                                          
In addition to the NP-1 trial in DPN, there are two other clinical trials for   
NP-1 currently underway.                                                        

    -- A Phase III trial in chemotherapy-induced peripheral neuropathy (CPN)    
       is being conducted by the National Cancer Institute (NCI)-funded         
       Community Clinical Oncology Program.  The double-blind, randomized       
       placebo-controlled study includes approximately 400 patients suffering   
       from painful CPN for at least 28 days following the conclusion of        
       chemotherapy.  The primary endpoint of the 12-week trial is change in    
       average daily pain intensity scores from baseline to the endpoint.       
       This trial is currently enrolling patients.                              

    -- A Phase IIb trial is underway in peripheral herpetic neuropathy.  This   
       500-patient, placebo- and active-controlled trial will compare the       
       efficacy and safety of NP-1 vs. gabapentin and placebo.  The primary     
       endpoint for this trial is the change in pain intensity over the four-   
       week duration of the trial. Preliminary results are expected early in    
       the second quarter of 2008.                                              

    About EpiCept Corporation                                                   
EpiCept is focused on unmet needs in the treatment of pain and cancer.  The     
Company's broad portfolio of pharmaceutical product candidates includes several 
pain therapies in clinical development and a lead oncology compound for AML with
demonstrated efficacy in a Phase III trial; a marketing authorization           
application for this compound is approaching a decision in Europe.  In addition,
EpiCept's ASAP technology, a proprietary live cell high-throughput caspase-3    
screening technology, can efficiently identify new cancer drug candidates and   
molecular targets that selectively induce apoptosis in cancer cells.   Two      
oncology drug candidates currently in clinical development that were discovered 
using this technology have also been shown to act as vascular disruption agents 
in a variety of solid tumors.                                                   

    Forward-Looking Statements                                                  
This news release and any oral statements made with respect to the information  
contained in this news release, contains forward-looking statements within the  
meaning of the Private Securities Litigation Reform Act of 1995.  Such          
forward-looking statements include statements which express plans, anticipation,
intent, contingency, goals, targets, future development and are otherwise not   
statements of historical fact.  These statements are based on EpiCept's current 
expectations and are subject to risks and uncertainties that could cause actual 
results or developments to be materially different from historical results or   
from any future results expressed or implied by such forward-looking statements.
Factors that may cause actual results or developments to differ materially      
include: the risk that our NP-1 clinical trials will not be successful, that    
NP-1 will not receive regulatory approval or achieve significant commercial     
success, the risk that Ceplene will not receive regulatory approval or marketing
authorization in the EU or that Ceplene, if approved, will not achieve          
significant commercial success, the risk that Myriad's development of Azixa(TM) 
will not be successful, the risk that Azixa will not receive regulatory approval
or achieve significant commercial success, the risk that we will not receive any
significant payments under our agreement with Myriad, the risk that the         
development of our other apoptosis product candidates will not be successful,   
the risk that our ASAP technology will not yield any successful product         
candidates, the risk that clinical trials for EPC 2407 will not be successful,  
that EPC 2407 will not receive regulatory approval or achieve significant       
commercial success, the risk that our other product candidates that appeared    
promising in early research and clinical trials do not demonstrate safety and/or
efficacy in larger-scale or later stage clinical trials, the risk that EpiCept  
will not obtain approval to market any of its product candidates, the risks     
associated with our need to raise additional financing to continue to meet our  
capital needs and our ability to continue as a going concern, the risks         
associated with dependence upon key personnel, the risks associated with        
reliance on collaborative partners and others for further clinical trials,      
development, manufacturing and commercialization of our product candidates; the 
cost, delays and uncertainties associated with our scientific research, product 
development, clinical trials and regulatory approval process; our history of    
operating losses since our inception; competition; litigation; risks associated 
with prior material weaknesses in our internal controls; and risks associated   
with our ability to protect our intellectual property.  These factors and other 
material risks are more fully discussed in EpiCept's periodic reports, including
its reports on Forms 8-K, 10-Q and 10-K and other filings with the U.S.         
Securities and Exchange Commission. You are urged to carefully review and       
consider the disclosures found in EpiCept's filings which are available at      
www.sec.gov or at www.epicept.com.  You are cautioned not to place undue        
reliance on any forward-looking statements, any of which could turn out to be   
wrong due to inaccurate assumptions, unknown risks or uncertainties or other    
risk factors.                                                                   

    EPCT-GEN                                                                    
                                                                                
    * Azixa is a registered trademark of Myriad Genetics, Inc.                  

SOURCE  EpiCept Corporation                                                     
    -0-                             12/03/2007                                  
/CONTACT:  EpiCept Corporation, Robert W. Cook, +1-914-606-3500,                
rcook@epicept.com; Media, Greg Kelley, +1-617-577-8110, Feinstein Kean          
Healthcare, gregory.kelley@fkhealth.com; or Investors, Kim Sutton Golodetz,     
+1-212-838-3777, kgolodetz@lhai.com, or Bruce Voss, +1-310-691-7100,            
bvoss@lhai.com, both of Lippert/Heilshorn & Associates /                        
    /Photo:  Newscom: http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO/  
    /Web site:  http://www.epicept.com /                                        
    (EPCT)