Report pursuant to the Danish Securities Trading Act, Section 28a


TopoTarget A/S
Symbion
Fruebjergvej 3
DK 2100 Copenhagen
Denmark
Tel: +45 39 17 83 92
Fax: +45 39 17 94 92
CVR-nr: 25695771

www.topotarget.com

Report pursuant to the Danish Securities Trading Act, Section 28a

Copenhagen - 6 December 2007 - Pursuant to the Danish Securities Trading Act,
Section 28a TopoTarget A/S (OMX: TOPO) is obliged to report on transactions by
members of its senior management and their related parties in shares issued by
TopoTarget A/S and related securities. 

Name	Leif Hamø
Reason	CFO
Issuer and ISIN code	TopoTarget A/S, DK0060086072
Transaction	Purchase
Trade date	27 November 2007
Market	Copenhagen Stock Exchange
Number	10,000
Market value in DKK	209,000

TopoTarget A/S
 

For further information, please contact:

Dr. Peter Buhl Jensen		Telephone	+45 39 17 83 41
Chief Executive Officer		Mobile	+45 21 60 89 22

Background information

About TopoTarget
TopoTarget (OMX: TOPO) is a biotech company, headquartered in Denmark and with
subsidiaries in the UK, Germany, Switzerland and the US, dedicated to finding
''Answers for Cancer'' and developing improved cancer therapies. TopoTarget is
founded and run by clinical cancer specialists and combines years of hands-on
clinical experience with in-depth understanding of the molecular mechanisms of
cancer. Focus lies on highly predictive cancer models and key cancer targets
(including HDACi, NAD+, mTOR, FASligand and topoisomerase II inhibitors) and a
strong development foundation has been built. TopoTarget has a broad portfolio
of small molecule pre-clinical drug candidates and eight drugs (both small
molecules and protein based) are in clinical development, including both novel
anti-cancer therapeutics and new cancer indications for existing drugs.
Savene™/Totect™ is TopoTarget's first product on the market. For more
information, please refer to www.topotarget.com. 

Attachments

announcement no. 42 07 28a 6 december 2007.pdf