Webcast Alert: Isis Pharmaceuticals Announces Financial Results and Highlights for Fiscal Year 2007 Conference Call

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| Source: Isis Pharmaceuticals, Inc.

CARLSBAD, Calif., March 3, 2008 (PRIME NEWSWIRE) -- Isis Pharmaceuticals, Inc. (Nasdaq:ISIS) announces the following webcast:



 What:  Isis Pharmaceuticals' Financial Results and Highlights for Fiscal
        Year 2007

 When:  Thursday, March 13, 2008, at 8:30 a.m. ET / 5:30 a.m. PT

 Where:  www.isispharm.com

 How:  Live on the Internet.  Simply log onto our website listed above.

 Contacts:  Kristina Lemonidis
            Associate Director, Investor Relations
            (760) 603-2490

            Amy Blackley, Ph.D.
            Manager, Corporate Communications
            (760) 603-2772

If you are unable to participate during the live event, a replay of the webcast will be available for a limited time at www.isispharm.com.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Ibis Biosciences, Inc., Isis' majority-owned subsidiary, is developing and commercializing the Ibis T5000(tm) Biosensor System, a revolutionary system to identify infectious organisms. Isis is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development and commercialization of microRNA therapeutics. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,500 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.