Rapinyl™ has received Swedish Marketing Authorization

Rapinyl™ has received Swedish Marketing Authorization

Uppsala, Sweden, 7th March 2008 - Orexo´s licensing partner for Rapinyl™in
Europe, ProStrakan Group plc announces that Rapinyl™ has received Swedish
Marketing Authorization. It is anticipated that the product branded as “Abstral”
will be launched in Sweden in Q3 2008 through Orexo´s joint venture with
ProStrakan, which operates in the Nordic countries.

Rapinyl™ is a fast-dissolving tablet for sublingual administration of fentanyl
intended for the treatment of breakthrough cancer pain, for which ProStrakan
Group plc, the international specialty pharmaceutical company, has in-licensed
exclusive rights in Europe from Orexo. ProStrakan today announces that it has
received Marketing Authorization in Sweden for Rapinyl™.

Sweden is the reference member state (RMS) for the wider EU regulatory filing of
Rapinyl™. The Swedish Medical Products Agency has taken the decision to issue a
Marketing Authorization for Sweden alone based on its assessment report made as
RMS for the EU regulatory procedure.  

ProStrakan expects that the wider EU regulatory procedure will complete during
2008. Meanwhile, it is anticipated that the product, branded as “Abstral”, will
be launched in Sweden in Q3 2008. Abstral will be marketed in Sweden through
Orexo´s joint venture with ProStrakan, which operates in the Nordic countries.
“This is an important milestone for Orexo and our late stage product portfolio.
The Swedish regulatory authority's decision to issue a Marketing Authorization
for Rapinyl™ (Abstral) while the EU regulatory procedure is still under way
underlines their continued support for Europe-wide approval of this product”,
said Dr Torbjörn Bjerke, President & CEO of Orexo.

For more information, please contact: 
Torbjörn Bjerke, President and CEO, Orexo AB
Tel: +46 (0)708-66 19 90
E-mail: torbjorn.bjerke@orexo.com

Claes Wenthzel, Executive Vice President & CFO, Orexo AB 
Tel: +46 (0)18-780 88 44 
E-mail: claes.wenthzel@orexo.com

TO THE EDITORS

About Rapinyl™

Rapinyl™ is a product for the treatment of acute pain. The first indication is
breakthrough pain in cancer. Rapinyl™ is based on Orexo´s unique proprietary
technology for sublingual administration, where a tablet is placed under the
tongue and rapidly disintegrates into ordered mucoadhesive units of the active
substance. This novel pharmaceutical preparation combines the properties of fast
dissolution, quicker onset of action and predictable effect. 

About Orexo

Orexo is a specialty pharmaceutical company, focusing on development of new,
patented drugs by combining well-documented substances with innovative
technologies, and the development of new treatments for respiratory and
inflammatory diseases.

Orexo has a broad and competitive late-stage product portfolio, including two
marketed products, five products in clinical phase and two undergoing
registration. 

To date, Orexo have out-licensed the market rights for Rapinyl™ for the US, the
EU and Japan markets, and signed a research collaboration with Boehringer
Ingelheim regarding the development of a new class of drugs to treat pain and
inflammation. Also, Orexo has established a Nordic sales force by entering into
a joint venture with ProStrakan.

Orexo has head office in Uppsala and is listed on the OMX Nordic Exchange
Stockholm, Small Cap (ticker: ORX).  

www.orexo.com


About ProStrakan 
ProStrakan Group plc is a rapidly growing international specialty pharmaceutical
company engaged in the development and commercialisation of prescription
medicines for the treatment of unmet therapeutic needs in major markets. 

ProStrakan's head office and development facilities are situated in Galashiels
in Scotland. EU-wide sales and marketing of ProStrakan's portfolio of products
are handled by commercial subsidiaries in the UK, France, Germany, Spain and
other EU countries. ProStrakan has recently announced plans to expand its
operations into the US. 

www.prostrakan.com