Lexicon to Report Second Quarter 2008 Financial Results On July 29, 2008

Conference Call and Webcast to Follow


THE WOODLANDS, Texas, July 17, 2008 (PRIME NEWSWIRE) -- Lexicon Pharmaceuticals, Inc. (Nasdaq:LXRX) will release its second quarter 2008 financial results on Tuesday, July 29, 2008 before the financial markets open. Lexicon management will hold a conference call to discuss its clinical development progress and financial results for second quarter 2008 at 11:00 a.m. Eastern Time on July 29, 2008.

The dial-in number for the conference call is 888-801-6504 (within the United States) or 913-312-1504 (international). The pass code for all callers is 2543723. Investors can access a live webcast of the call at www.lexpharma.com. An archived version of the webcast will be available on the website through August 1, 2008.

About Lexicon

Lexicon is a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease. Lexicon currently has development programs underway for autoimmune disease, carcinoid syndrome, cognitive disorders, diabetes and irritable bowel syndrome, with a goal of advancing 10 drug candidates into human clinical trials by the end of 2010 (10TO10 program). The company is using its proprietary gene knockout technology to characterize approximately 5,000 genes in its Genome5000(tm) program, and has discovered more than 100 promising drug targets. Lexicon has applied small molecule chemistry and antibody technology to these biologically-validated targets to create an extensive pipeline of clinical and preclinical programs. For additional information about Lexicon and its programs, please visit www.lexpharma.com.

The Lexicon Pharmaceuticals, Inc. logo is available at http://www.primenewswire.com/newsroom/prs/?pkgid=4799

Safe Harbor Statement

This press release contains "forward-looking statements," including statements relating to Lexicon's growth and future operating results, discovery and development of products, strategic alliances and intellectual property, as well as other matters that are not historical facts or information. All forward-looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward-looking statements. Information identifying such important factors is contained under "Factors Affecting Forward-Looking Statements" and "Risk Factors" in Lexicon's annual report on Form 10-K for the year ended December 31, 2007, as filed with the Securities and Exchange Commission. Lexicon undertakes no obligation to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise.



            

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