WORCESTER, Mass., Jan. 12, 2009 (GLOBE NEWSWIRE) -- Generex Biotechnology Corporation (Nasdaq:GNBT) (www.generex.com) announced today the publication of a report reviewing the studies performed to date with the immunotherapeutic agent AE37, which is being developed by the Company's wholly-owned immunotherapeutics subsidiary Antigen Express, Inc. (www.antigenexpress.com). The compound is currently the subject of a Phase II clinical trial in patients with breast cancer, a Phase I clinical trial in prostate cancer patients, and another Phase I clinical trial wherein the compound will be combined with another vaccine peptide in patients with either ovarian or breast cancer.
The report, entitled "CD4+ T cells in antitumor immunity: utility of an Ii-Key HER2/neu hybrid peptide vaccine (AE37)", appeared in the January 2009 issue of Expert Opinion on Biological Therapy (Vol. 9, No. 1, Pages 71-78) and is co-authored by Dr. Eric von Hofe, President of Antigen Express. The study reviews the clinical as well as the pre-clinical data on AE37, comparing it with other vaccines that have been investigated in the clinic. In addition to being shown to be safe and well tolerated in clinical studies, the report concludes that AE37 has superior immunogenicity to other peptide vaccines investigated to date. In addition, the value of specific CD4+ T cell stimulation is also underscored.
About Generex Biotechnology Corporation
Generex is engaged in the research, development and commercialization of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company's proprietary RapidMist device. The Company's flagship product, oral insulin (Generex Oral-lyn), which is available for sale in India and Ecuador for the treatment of subjects with Type-1 and Type-2 diabetes, is in Phase III clinical trials at several sites around the world. Antigen Express, Inc. is a wholly owned subsidiary of Generex. The core platform technologies of Antigen Express comprise immunotherapeutics for the treatment of malignant, infectious, allergic, and autoimmune diseases. For more information, visit the Generex website at www.generex.com or the Antigen Express website at www.antigenexpress.com.
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