WALTHAM, Mass., March 19, 2009 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN)
(XSSE:OXGN), a clinical-stage, biopharmaceutical company developing novel
therapeutics to treat cancer and eye diseases, reported financial results for
the quarter and year ended December 31, 2008.
Financial Results
The Company reported a net loss for the fourth quarter of 2008 of $1.8 million,
or $0.05 per share, compared with a net loss of $5.8 million, or $0.21 per
share, for the same period in 2007.
For the year ended December 31, 2008, the net loss was $21.4 million, or $0.70
per share, compared with a net loss of $20.4 million, or $0.73 per share, for
the comparable period in 2007.
The loss from operations for the fourth quarter of 2008 was $5.8 million
compared to a loss from operations of $6.2 million for the same period in 2007.
The loss from operations for the year ended December 31, 2008 was $25.9 million
compared with loss from operations of $22.3 million for the comparable period
in 2007.
The increase in loss from operations for the twelve month period is
attributable to an increase in operating expenses which was driven primarily by
a higher level of clinical development activities, including the ongoing FACT
study of fosbretabulin (ZYBRESTAT) in anaplastic thyroid cancer (ATC), the
FALCON study of fosbretabulin in non-small cell lung cancer (NSCLC) as well as
the management of other ongoing clinical trials and drug development
activities. The increase in costs associated with clinical development
activities was offset in part by lower general and administrative expenses for
the periods reported.
In the fourth quarter of 2008, OXiGENE recorded a non-cash gain totaling $3.3
million resulting from changes in the valuation of warrants issued in 2008. The
majority of the gain resulted from warrants to purchase 11,281,877 shares of
OXiGENE common stock issued to Symphony Capital on October 17, 2008 and
subsequently exercised in full at the price of $1.11 per share by Symphony
Capital in December 2008. Warrants to purchase 250,000 shares of OXiGENE common
stock issued to Kingsbridge Capital in February 2008 resulted in a gain of
approximately $23,000. The gain represents the difference in valuation of the
warrants in October 2008, the month in which OXiGENE completed the strategic
collaboration with Symphony Capital, and December 30, 2008 in the case of the
Symphony warrant and December 31, 2008 in the case of the Kingsbridge warrant.
The gain is due to the decrease in the quoted price of the Company's common
stock during the measurement period.
As previously announced, OXiGENE reported cash, cash equivalents and marketable
securities on December 31, 2008 of approximately $33.6 million, including
investments held by Symphony ViDA, Inc. of $14.7 million, compared with
approximately $28.4 million on December 31, 2007.
"OXiGENE delivered a strong performance in 2008 marked by clear progress in our
drug development programs, led by our ZYBRESTAT pivotal trial in anaplastic
thyroid cancer. We kept a tight focus on key objectives, maintained a high
level of fiscal responsibility and established an enabling strategic
partnership with Symphony Capital," said John A. Kollins, OXiGENE's Chief
Executive Officer. "We believe that 2009 will be an equally productive year for
our company, as we continue to drive our oncology and ophthalmology product
pipeline forward toward key value inflection points, advance strategic business
and corporate development initiatives and thereby increase the value of our
therapeutic assets."
About ZYBRESTAT (fosbretabulin)
ZYBRESTAT is currently being evaluated in a pivotal registration clinical trial
in anaplastic thyroid cancer (ATC) under a Special Protocol Assessment
agreement with the U.S. Food and Drug Administration (FDA). OXiGENE believes
that ZYBRESTAT is poised to become the first therapeutic product in a novel
class of small-molecule drug candidates called vascular disrupting agents
(VDAs). Through interaction with vascular endothelial cell cytoskeletal
proteins, ZYBRESTAT selectively targets and collapses tumor vasculature,
thereby depriving the tumor of oxygen and causing death of tumor cells. In
clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and
selective activity against tumor vasculature, as well as clinical activity
against ATC, ovarian cancer and various other solid tumors. In clinical trials
in patients with forms of macular degeneration, intravenously-administered
ZYBRESTAT has demonstrated activity, and the Company's objective is to develop
a convenient and patient-friendly topical formulation of ZYBRESTAT for
ophthalmological indications. OXiGENE is developing ZYBRESTAT for ophthalmology
under the strategic drug development partnership it established with Symphony
Capital in October 2008.
About OXi4503
OXi4503 (combretastatin A1 di-phosphate / CA1P) is a dual-mechanism vascular
disrupting agent (VDA) that is being developed in clinical trials for the
treatment of solid tumors. Like its structural analog, ZYBRESTAT(TM)
(fosbretabulin / CA4P), OXi4503 has been observed to block and destroy tumor
vasculature, resulting in extensive tumor cell death and necrosis. In addition,
preclinical data indicate that OXi4503 is metabolized by oxidative enzymes
(e.g., tyrosinase and peroxidases), which are elevated in many solid tumors and
tumor white blood cell infiltrates, to an orthoquinone chemical species that
has direct cytotoxic effects on tumor cells. Preclinical studies have shown
that OXi4503 has (i) single-agent activity against a range of xenograft tumor
models; and (ii) synergistic or additive effects when incorporated in various
combination regimens with chemotherapy, molecularly-targeted therapies
(including tumor-angiogenesis inhibitors), and radiation therapy. OXi4503 is
currently being evaluated as a monotherapy in a Phase 1 dose-escalation trial
in patients with advanced solid tumors. OXiGENE is developing OXi4503 under the
strategic drug development partnership it established with Symphony Capital in
October 2008.
About OXiGENE
OXiGENE is a clinical-stage biopharmaceutical company developing novel
therapeutics to treat cancer and eye diseases. The Company's major focus is
developing vascular disrupting agents (VDAs) that selectively disrupt abnormal
blood vessels associated with solid tumor progression and visual impairment.
OXiGENE is dedicated to leveraging its intellectual property and therapeutic
development expertise to bring life-extending and life-enhancing medicines to
patients.
The OXiGENE, Inc. logo is available at
http://www.globenewswire.com/newsroom/prs/?pkgid=4969
Safe Harbor Statement
This news release contains "forward-looking statements" within the meaning of
the Private Securities Litigation Reform Act of 1995. Any or all of the
forward-looking statements in this press release may turn out to be wrong.
Forward-looking statements can be affected by inaccurate assumptions OXiGENE
might make or by known or unknown risks and uncertainties, including, but not
limited to, the enrollment rate for patients in the ZYBRESTAT pivotal trial for
anaplastic thyroid cancer, an interim analysis of the same, reporting of final
results from the Phase 2 clinical trial of ZYBRESTAT in patients with
platinum-resistant ovarian cancer, initiation of a Phase 1b clinical trial of
OXi4503 in patients with hepatic tumors, presentation of preclinical data on
OXi4503 in acute myeloid leukemia, initiation of a Phase 1b clinical trial of
OXi4503 in acute myeloid leukemia, completion of enrollment in the ongoing
Cancer Research United Kingdom sponsored Phase 1 clinical trial of OXi4503 in
patients with advanced solid tumors, timing of reporting final data from the
Phase 1 trial, timing and success of preclinical studies and initiation of a
clinical trial of topical-route ZYBRESTAT, timing of reporting interim and
final data from the Phase 2 clinical trial of ZYBRESTAT in NSCLC, initiation of
a Phase 2 clinical trial of ZYBRESTAT for ophthalmology, administered
intravenously, in a choroidal neovascularization indication, and timing or
execution of a potential strategic collaboration on any product or indication
or any other transaction. Additional information concerning factors that could
cause actual results to materially differ from those in the forward-looking
statements is contained in OXiGENE's reports to the Securities and Exchange
Commission, including OXiGENE's reports on Form 10-K, 10-Q and 8-K. However,
OXiGENE undertakes no obligation to publicly update forward-looking statements,
whether because of new information, future events or otherwise. Please refer to
our Annual Report on Form 10-K for the fiscal year ended December 31, 2007.
OXiGENE, Inc.
Condensed Consolidated Balance Sheets
(All amounts in 000's)
(Unaudited)
December 31, December 31,
2008 2007
----------- -----------
Assets
Cash, cash equivalents and
marketable securities $ 18,918 $ 28,438
Investments held by Symphony ViDA, Inc. 14,663 --
License agreement 581 679
Other assets 869 947
-------- --------
Total assets $ 35,031 $ 30,064
======== ========
Liabilities and stockholders' equity
Accounts payable and accrued liabilities $ 5,826 $ 5,207
Liabilty for potential stock issuances 466 --
Non controlling interest in
Symphony ViDA, Inc. 9,432 --
Total stockholders' equity 19,307 24,857
-------- --------
Total liabilities and stockholders'
equity $ 35,031 $ 30,064
======== ========
OXiGENE, Inc.
Condensed Consolidated Statements of Operations
(All amounts in 000's except per share amounts)
(Unaudited)
Three months ended Twelve months ended
December 31, December 31,
----------------- -------------------
2008 2007 2008 2007
------- ------- -------- --------
License revenue $ -- $ 5 $ 12 $ 12
Costs and expenses:
Research and development 4,566 4,494 18,434 14,130
General and administrative 1,214 1,667 7,518 8,155
------- ------- -------- --------
Total costs and expenses 5,780 6,161 25,952 22,285
Operating loss (5,780) (6,156) (25,940) (22,273)
------- ------- -------- --------
Gain on change in
valuation of warrants 3,335 -- 3,335 --
Investment income 72 394 618 1,955
Other expense, net 53 (35) 66 (71)
------- ------- -------- --------
Net loss before non
controlling interest in
Symphony ViDA (2,320) (5,797) (21,921) (20,389)
Loss attributed to non
controlling interest in
Symphony ViDA 520 -- 520 --
Net loss $(1,800) $(5,797) $(21,401) $(20,389)
======= ======= ======== ========
Basic and diluted net loss
per common share $ (0.05) $ (0.21) $ (0.70) $ (0.73)
Weighted average number of
common shares outstanding 37,482 28,035 30,653 27,931
CONTACT: OXiGENE, Inc.
Investor and Media Contact:
Michelle Edwards, Investor Relations
650-635-7006
medwards@oxigene.com
OXiGENE Reports Fourth Quarter and Year-End 2008 Results
| Source: Oxigene, Inc.