TopoTarget A/S Symbion Fruebjergvej 3 DK 2100 Copenhagen Ø Denmark Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com Copenhagen - 2 July, 2009 - Pursuant to the Danish Securities Trading Act, Section 28a TopoTarget A/S (OMX: TOPO) is obliged to report on transactions by members of its board of directors, senior management and their related parties in shares issued by TopoTarget A/S and related securities. Name Buhl Krone Holding ApS, a company wholly-owned by CEO Reason of TopoTarget A/S, Peter Buhl Jensen Issuer TopoTarget A/S ISIN code DK0060003556 Transaction Acquisition (subscription) of TopoTarget shares Trade date 29 June 2009 Market NASDAQ OMX Copenhagen A/S Number 239.222 Market value in DKK 478.444 Name Håkan Åström Reason Chairman of TopoTarget A/S Issuer TopoTarget A/S ISIN code DK0060003556 Transaction Acquisition (subscription) of TopoTarget shares Trade date 29 June 2009 Market NASDAQ OMX Copenhagen A/S Number 317.000 Market value in DKK 634.000 TopoTarget A/S For further information, please contact: Peter Buhl Jensen Telephone +45 39 17 83 92 CEO Mobile +45 21 60 89 22 Background information About TopoTarget TopoTarget (OMX: TOPO) is an international biotech company headquartered in Denmark, dedicated to finding ''Answers for Cancer'' and developing improved cancer therapies. The company was founded and is run by clinical cancer specialists and combines years of hands-on clinical experience with in-depth understanding of the molecular mechanisms of cancer. TopoTarget has a broad clinical pipeline but is currently focusing on the development of belinostat, which has shown proof of concept as monotherapy in treating haematological malignancies and positive results in solid tumours where it can be used in combination with full doses of chemotherapy, and is in phase III in PTCL. TopoTarget's expertise in translational research is utilizing its highly predictive in vivo and in vitro cancer models. TopoTarget is directing its efforts on key cancer targets including HDACi, NAD+, mTOR, FasLigand and topoisomerase II inhibitors. The company's first marketed product Savene®/Totect® was approved by EMEA in 2006 and the FDA in 2007 and is marketed by TopoTarget's own sales force in Europe and the US. For more information, please refer to www.topotarget.com.