Abstral EU success continues. Orexo receives sales milestone of 3.3 MEUR.


Uppsala, Sweden – May 25, 2012 - Orexo AB (STO: ORX) announced today that
accumulated sales of Abstral has surpassed 65 MEUR, which was faster than
earlier anticipated and results in a 3.3 MEUR milestone payment from ProStrakan.

Abstral is the leading new fast acting fentanyl product in Europe and this
position has been further strengthened during the first four months of 2012.
Abstral has continued to win market share. The growth during first quarter of
2012 was 39%, driven especially by the key markets France, Italy and Spain.

Anders Lundström, Chief Executive Officer, of Orexo said:
“I am pleased to see continued strong Abstral sales growth in Europe. The
product has during 2012 further strengthened its leading market position among
the new fast acting fentanyl products for treatment of break through pain in
cancer patients. Abstral continued success in Europe highlights the advantages
of Orexo’s proprietary sublingual formulation technology.”

For further information, please contact:
Carl-Johan Blomberg, Chief Financial Officer
Phone: +46 (0)706 33 67 11, E-mail: carl-johan.blomberg@orexo.com

Nikolaj Sørensen, Chief Commercial Officer
Phone: +46 (0)703 50 78 88, E-mail: nikolaj.sorensen@orexo.com

About Orexo
Orexo AB is an emerging specialty pharma company developing improved treatments
using proprietary drug delivery technology. Orexo’s expertise is within the area
of reformulation technologies and especially sublingual formulations.

Orexo has a portfolio of revenue generating EU and US approved products
currently marketed under licence and a pipeline of several reformulations of
approved compounds for areas of unmet medical need. Orexo also has collaboration
projects with several international pharma companies.

Orexo AB is Swedish headquartered with 100 employees and listed on NASDAQ-OMX.
The largest shareholders are Danish Novo A/S and Swedish HealthCap. More
information can be found at www.orexo.com

About Abstral
Abstral is the novel, rapidly-disintegrating, sublingual (under the tongue)
formulation of fentanyl, a well-established opioid used for the management of
episodes of breakthrough pain experienced by cancer patients who are already
receiving opioid analgesics for chronic pain.

Note: This is information that Orexo AB (publ) discloses pursuant to the
Financial Instruments Trading Act and/or Securities Market Act. The
information was provided for public release on May 25, 2012 at 10:00 CEST.
This press release has been prepared in both Swedish and English. In the event
of any discrepancy in the content of the two versions, the Swedish version
shall take precedence.

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