DGAP-News: PAION AG / Key word(s): Research Update PAION DEUTSCHLAND GMBH RECEIVES A GRANT WORTH EUR 0.7 MILLION FROM THE FEDERAL MINISTRY OF EDUCATION AND RESEARCH (BMBF) FOR RESEARCH INTO THE POTENTIAL OF THROMBOMODULIN - MUTANTS 02.07.2012 / 07:30 --------------------------------------------------------------------- PAION DEUTSCHLAND GMBH RECEIVES A GRANT WORTH EUR 0.7 MILLION FROM THE FEDERAL MINISTRY OF EDUCATION AND RESEARCH (BMBF) FOR RESEARCH INTO THE POTENTIAL OF THROMBOMODULIN - MUTANTS - Funding of research, development of production and preclinical development of the potential of novel thrombomodulin - mutants - Lead identification until 2015 - Target indications: Haemophilia and other states of hyperfibrinolysis - Funding Number: '031A102 - KMU - Innovativ 9: Herstellung, Analyse und Eignung von TAFI optimierten Thrombomodulin - Analoga zum Einsatz in der Hämophilie' Aachen (Germany), 02 July 2012 - PAION AG (ISIN DE000A0B65S3; Frankfurt Stock Exchange General Standard: PA8) today announced that the Federal Ministry for Education and Research (BMBF) with the funding initiative 'KMU-INNOVATIV: Biotechnologie - BioChance' is subsidizing PAION Deutschland GmbH for the production and preclinical development of novel PAION thrombomodulin (Thbd) - mutants with EUR 0.7 million until end of 2014. The lead candidate may offer improved options for the treatment of haemophilia and several acute disease states, which involve hyperfibrinolysis. Currently PAION is testing its soluble Thbd, Solulin, in a Phase Ib study in haemophilia patients. Hyperfibrinolysis is a coagulation deficit that leads to unstable clots and their premature dissolution. In patients suffering from Haemophilia, this causes delayed or re-bleeding as the major complication. In the absence of haemophilia, the same disorder can result in blood losses and a need for blood transfusions, i.e. when patients are treated in the ICU after surgery or severe trauma. Solulin and its mutants correct hyperfibrinolysis via the so-called 'Thrombin Activatable Fibrinolysis Inhibitor' (TAFI) pathway. The novelty of the approach lies in the anticipated specific TAFI activation to mitigate or prevent coagulation failure. The first step of the funded program is the production of several lead molecules. It is aimed to identify one or more mutants, which then will be qualified for clinical testing. Overall, a total budget of EUR 1.4 million is estimated, of which 50% (EUR 0.7 million) are funded by the BMBF until the end of the project end of 2014. The early stage research into the potential of the Thbd-mutants is independent of the ongoing Solulin Phase Ib trial for the treatment of haemophilia. Initial results of this study are expected later this year. Dr. Mariola Söhngen, PAION's Chief Medical Officer, comments: 'The funding of this innovation by the BMBF allows us to exploit the gained know-how with Solulin at a time of scarce funding. The Thbd-mutants have the potential to resolve a medical problem (hyperfibrinolysis) with a new mechanism that is derived from a human protein (Thbd). As this new treatment addresses a medical problem in the ICU eventual drug candidates also may have a prominent place in our emerging anaesthesia portfolio.' ### About PAION PAION is headquartered in Aachen, Germany and has a second site in Cambridge, UK. The company is specialised in developing innovative drugs for the hospital-based treatment in indications for which there is a substantial unmet medical need. PAION is extending its 'Search & Develop' business model, by transforming into a 'Specialty Pharma Company', with a focus on anaesthesia products. About KMU-innovative: Priority for Cutting-Edge Research in SMEs BMBF has opened a number of its specialised programmes of research funding especially for projects of cutting-edge research in SMEs. The industrial research and pre-competitive development projects are funded to strengthen the innovation capability of SMEs in Germany. The aim is to make research funding as part of specialised programmes more attractive to SMEs. For more information, visit: http://www.foerderinfo.bund.de/de/2248.php. About Solulin Solulin is an improved variant of the human protein Thrombomodulin, an important natural regulator of numerous processes in the body including the clotting system. Recent research has highlighted the anti-inflammatory potential of Thrombomodulin/Solulin. Other than native Thrombomodulin, which is anchored in the wall of blood vessels, Solulin is distributed by the blood stream to reach its potential site of action. At low concentrations, Solulin antagonizes premature dissolution of clots and hence supports undisturbed coagulation. Solulin has already been successfully tested in a Phase I study which confirmed the excellent safety profile of the substance. Besides haemophilia, the development of Solulin for the treatment of radiation injury could be a suitable option. Contact Ralf Penner Director Investor Relations / Public Relations PAION AG Martinstrasse 10-12 52062 Aachen - Germany Phone: +49 241 4453-152 E-mail: r.penner@paion.com www.paion.com Disclaimer: This release contains certain forward-looking statements concerning the future business of PAION AG. These forward-looking statements contained herein are based on the current expectations, estimates and projections of PAION AG's management as of the date of this release. They are subject to a number of assumptions and involve known and unknown risks, uncertainties and other factors. Should actual conditions differ from the Company's assumptions, actual results and actions may differ materially from any future results and developments expressed or implied by such forward-looking statements. Considering the risks, uncertainties and other factors involved, recipients should not rely unreasonably upon these forward-looking statements. PAION AG has no obligation to periodically update any such forward-looking statements to reflect future events or developments. postoperative blood losses and transfusion requirements in a number of types of surgery, with potential cost and tolerability adva End of Corporate News --------------------------------------------------------------------- 02.07.2012 Dissemination of a Corporate News, transmitted by DGAP - a company of EquityStory AG. The issuer is solely responsible for the content of this announcement. DGAP's Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Media archive at www.dgap-medientreff.de and www.dgap.de --------------------------------------------------------------------- Language: English Company: PAION AG Martinstr. 10-12 52062 Aachen Germany Phone: +49 (0)241-4453-0 Fax: +49 (0)241-4453-100 E-mail: info@paion.com Internet: www.paion.com ISIN: DE000A0B65S3 WKN: A0B65S Listed: Regulierter Markt in Frankfurt (General Standard); Freiverkehr in Berlin, Düsseldorf, Hamburg, München, Stuttgart End of News DGAP News-Service --------------------------------------------------------------------- 176011 02.07.2012
DGAP-News: PAION DEUTSCHLAND GMBH RECEIVES A GRANT WORTH EUR 0.7 MILLION FROM THE FEDERAL MINISTRY OF EDUCATION AND RESEARCH (BMBF) FOR RESEARCH INTO THE POTENTIAL OF THROMBOMODULIN - MUTANTS
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