SECOND QUARTER AND HALF YEAR RESULTS 2012


As expected, generic competition and challenging market conditions reflected in
lower second quarter revenues. Progress made on execution of long-term
priorities, with the on-market portfolio and the pipeline strengthened through
recent business development initiatives. Financial targets for full year
unchanged.
Revenue for the second quarter was $6,660 million, down 18 percent at constant
exchange rates (CER).

-Loss of exclusivity on several key brands accounted for 15 percentage points of
the revenue decline. Resilient performance for Crestor. Strong growth continued
for ONGLYZATM, Iressa and Faslodex.

-As expected, further limitations in the supply chain at our plant in Sweden
continued into the second quarter; the estimated impact on second quarter
revenue was around 2 percent. The Company estimates the impact for the full year
will be around 1 percent of revenue.

-Emerging Markets revenue increased by 1 percent at CER. Supply chain issues
impacted Emerging Markets revenue; adjusted for this, revenue growth would have
been around 8 percent.

Core EPS was $1.53 in the second quarter, a 6 percent decline at CER.

-Core EPS benefited by $240 million ($0.19 per share) due to the tax settlement
of a cross border transfer pricing issue. The effective tax rate for the full
year is now estimated to be around 20 percent.

Reported EPS in the second quarter was down 11 percent at CER to $1.27.

Diabetes alliance will expand through Bristol-Myers Squibb’s acquisition of
Amylin Pharmaceuticals.

The Board has recommended a first interim dividend of $0.90. Net share
repurchases were $1.6 billion in the first half; target for full year remains
$4.5 billion, subject to market conditions and business needs.

Core EPS target range for the full year maintained at $5.85 to $6.15.


Financial Summary

+---------+-------+-------+------+---++-------------+-------------+------+---+
|Group    |    2nd|    2nd|Actual|CER||Half Year2012|Half Year2011|Actual|CER|
|         |Quarter|Quarter|     %|  %||           $m|           $m|     %|  %|
|         |   2012|   2011|      |   ||             |             |      |   |
|         |     $m|     $m|      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Revenue  |  6,660|  8,430|   -21|-18||       14,009|       16,722|   -16|-15|
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Reported |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Operating|  1,868|  2,965|   -37|-32||        4,028|        6,366|   -37|-35|
|Profit   |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Profit   |  1,763|  2,858|   -38|-33||        3,816|        6,146|   -38|-36|
|before   |       |       |      |   ||             |             |      |   |
|Tax      |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Earnings |  $1.27|  $1.53|   -17|-11||        $2.55|        $3.61|   -29|-27|
|per Share|       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Core*    |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Operating|  2,269|  3,322|   -32|-27||        5,266|        7,000|   -25|-23|
|Profit   |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Profit   |  2,164|  3,215|   -33|-28||        5,054|        6,780|   -25|-23|
|before   |       |       |      |   ||             |             |      |   |
|Tax      |       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+
|Earnings |  $1.53|  $1.73|   -12| -6||        $3.34|        $3.96|   -16|-13|
|per Share|       |       |      |   ||             |             |      |   |
+---------+-------+-------+------+---++-------------+-------------+------+---+

*  Core financial measures are supplemental non-GAAP measures which management
   believe enhance understanding of the Company’s performance; it is upon
   these measures that financial guidance for 2012 is based.   See pages 2 & 4
   for a definition of Core financial measures and a reconciliation of Core to
   Reported financial measures.

Simon Lowth, Interim Chief Executive Officer, commenting on the results, said:
“As we expected, the loss of exclusivity on some key brands and tough market
conditions have resulted in a decline in revenue and earnings in the second
quarter. Despite these challenges, we are on track to achieve our financial
targets for the full year.

“The results in the first half of the year reflect the resilience of several of
our brands and the benefits of disciplined cost management. Building on the
collaboration with Amgen and the acquisition of Ardea, we continued to bolster
our pipeline and portfolio through an exciting opportunity to expand our
diabetes alliance with Bristol-Myers Squibb.

“Our long-term priorities remain unchanged. We are driving the performance of
brands that retain exclusivity, investing in markets with long-term potential,
reshaping the cost base for sustainable competitiveness and continuing to drive
for productivity on our investments in innovation, whether internally or
externally sourced.”

CONTACT INFORMATION

Media Enquiries:
Esra Erkal-Paler (London)                                       +44 20 7604 8030
Sarah Lindgreen (London)                                      +44 20 7604 8033
Tony Jewell (Wilmington)                                         +1 302 885 4594
Ann-Leena Mikiver (Södertälje)                                +46 8 553 260
20/+46 707 428836

Analyst/Investor Enquiries:
James Ward-Lilley (London)                                      +44 20 7604 8122
Karl Hård (London)                                                    +44 20
7604 8123
Nicklas Westerholm (London)                                    +44 20 7604 8124
Ed Seage/Jörgen Winroth (US)                                 +1 302 886 4065/+1
212 579 0506

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