ChronTech’s controlled clinical study of ChronVac-C® gives mixed results

ChronTech now has made the first analysis of 12 weeks treatment with interferon
and ribavirin in patients with (n=17) or without (n=12) two monthly previous
vaccinations with 500 µg ChronVac-C® administered with Inovio’s Medpulser. No
serious adverse events were noted and the number of moderate adverse events were
lower in the vaccinated group than in the non-vaccinated group. At treatment
week 12, 71 % of the vaccinated group had less than 15 international units of
HCV RNA as compared to 58 % in the non-vaccinated group. As regards to number of
patients who were virus negative at treatment week 12 in the vaccinated group 65
% were HCV RNA negative as compared to 58 % in the non-vaccinated group. All in
all the study shows that ChronVac-C® is very safe but the differences in
treatment outcome so far were too low to be statistically significant.

“Obviously it is with mixed feelings we receive these results. We had hoped for
a larger difference between the two groups. Possibly this could be explained by
the fact that we in this study chose to giver fewer vaccination doses than in
our previous study. However, we will have to await the ongoing analysis of the
vaccine activated immune responses before we can draw any definite conclusions”
says ChronTech’s CEO Anders Vahlne.

For more information, please contact:

Anders Vahlne, CEO and Head of Research, ChronTech Pharma AB

Mobile phone: +46 709 28 05 28,
E-mail: anders.vahlne@ki.se

About ChronTech

ChronTech develops the therapeutic DNA vaccines ChronVac-C® and ChronVac-B drugs
against chronic hepatitis C virus and hepatitis B virus infections, i.e. chronic
infections with jaundice causing viruses which can lead to liver cirrhosis and
liver cancer. ChronTech has also developed and further develops a patent pending
new type of injection needle for a more effective uptake of DNA vaccines.
ChronTech also have part ownership in the wound healing therapy ChronSeal®, and
in the new platform technology RAS®. The ChronTech share is admitted to trade on
First North. Remium Nordic AB is Certified Adviser for ChronTech. For more
information, please visit: www.chrontech.se

In the event of any discrepancy between the Swedish and English versions of this
press release, the Swedish version will take precedence.