Gentium Provides EMA Update

Conference Call and Webcast on Friday July 26, 2013

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| Source: Gentium S.p.A.

VILLA GUARDIA (COMO), Italy, July 26, 2013 (GLOBE NEWSWIRE) -- Gentium S.p.A. (Nasdaq:GENT) (the "Company") announced that today, Friday, July 26, 2013, it will provide update on Defibrotide Marketing Authorization and hold a conference call and live webcast at 8:00 a.m. US ET / 14:00 p.m. CET.

To participate in the call, interested parties may dial 1 866 966 9439 (North America toll-free) or +44 (0) 1452 555 566 (international/toll) to register ten minutes before the call is scheduled to begin and use confirmation code 25188367. The event will also be broadcast live on the internet at http://www.gentium.com/investors/event-calendar. The event will be archived for replay for 30 days. The replay can be accessed on the Company's website, http://www.gentium.com/investors/event-calendar or at 1 866 247 4222 (North America toll-free) or +44 (0) 1452 55 00 00 (international/toll) using Conference ID 25188367.

About Gentium

Gentium S.p.A., located in Como, Italy, is a biopharmaceutical company focused on the development and manufacture of drugs to treat and prevent a variety of diseases and conditions, including vascular diseases related to cancer and cancer treatments. Defibrotide, the Company's lead product candidate, is an investigational drug that has been granted Orphan Drug status by the U.S. FDA and Orphan Medicinal Product Designation by the EMA both to treat and to prevent VOD and Fast Track Designation by the U.S. FDA to treat VOD.

Cautionary Note Regarding Forward-Looking Statements

This press release contains "forward-looking statements." In some cases, you can identify these statements by forward-looking words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "predict," "potential" or "continue," the negative of these terms and other comparable terminology. These statements are not historical facts but instead represent the Company's belief regarding future results, many of which, by their nature, are inherently uncertain and outside the Company's control. It is possible that actual results, including with respect to any financial forecast or the possibility of any future regulatory approval, may differ materially from those anticipated in these forward-looking statements. For a discussion of some of the risks and important factors that could affect future results, see the discussion in our Form 20-F filed with the Securities and Exchange Commission under the caption "Risk Factors."

Gentium S.p.A.
Salvatore Calabrese, +39 031-5373-260
SVP Finance & Chief Financial Officer