RaySearch Laboratories AB (publ.) has received an order for its RayStation®
treatment planning system from CNAO Foundation (Centro Nazionale di Adroterapia
Oncologica) in Pavia, Italy.

CNAO is a clinical facility created and financed by the Italian Ministry of
Health that will supply ion beam therapy to patients from all of Italy. The
proton and carbon ion beams are generated by an accelerator complex built by
CNAO in collaboration with other European institutions including INFN, CERN and
GSI. CNAO started treating patients with proton beams in September 2011. The
first patient treatment with carbon ions took place in November 2012. From 2014
the facility will start running at full capacity with the operational goal to
treat about 2000 patients annually.

CNAO is the second combined proton and carbon ion center to select the
RayStation® treatment planning system following MedAustron in Wiener Neustadt,
Austria. The ion beam therapy delivered at these centers represents the most
advanced form of external radiotherapy where the tumor is irradiated with
protons or carbon ions. Compared to conventional photon radiotherapy the energy
deposition of the ion beams can be controlled much more effectively. The
radiation dose can be delivered more precisely and as a result, the unwanted
dose to healthy tissues is reduced, leading to a reduction of treatment-related
side effects. In addition, radiation therapy with carbon ions can be used to
target tumors with low levels of oxygen, so called hypoxic tumors, for which
conventional radiation therapy has limited effect.

The order comprises all of RayStation’s current functionality as well as the new
carbon ion planning functionality. The carbon ion planning module, which builds
on the current pencil beam scanning functionality for protons, will serve both
normal clinical use and research needs. The module optimizes the scanning
pattern for discrete and line scanned beams with physical dose calculated either
by a pencil beam algorithm or a Monte Carlo algorithm. The system will use
RaySearch’s well-proven optimization platform to optimize directly the
biologically effective dose.

Johan Löf, CEO of RaySearch Laboratories AB says: “This order from one of the
leading radiation therapy centers in the world is important to us for several
reasons. Not only is it the second RayStation® order in the field of carbon
ions, it also provides unique and essential validation and research
opportunities to support the development of RayStation’s carbon ion planning
module. We really look forward to collaborating with the CNAO team in this
field.”

About RayStation®
RayStation® integrates all RaySearch’s advanced treatment planning solutions
into a flexible treatment planning system. It combines unique features such as
multi-criteria optimization tools with full support for 4D adaptive radiation
therapy. It also includes functionality such as RaySearch’s market-leading
algorithms for IMRT and VMAT optimization and highly accurate dose engines for
photon, electron and proton therapy. The system is built on the latest software
architecture and has a graphical user interface offering state-of-the-art
usability.

About RaySearch
RaySearch Laboratories is a medical technology company that develops advanced
software solutions for improved radiation therapy of cancer. RaySearch’s
products are mainly sold through license agreements with leading partners such
as Philips, Nucletron, IBA, Varian, Accuray and Brainlab. To date, 15 products
have been launched through partners and RaySearch’s software is used at over
2,300 clinics in more than 30 countries. In addition, RaySearch offers the
proprietary treatment planning system RayStation® directly to clinics. RaySearch
was founded in 2000 as a spin-off from Karolinska Institutet in Stockholm and
the company is listed in the Small Cap segment on NASDAQ OMX Stockholm.

For more information about RaySearch, visit www.raysearchlabs.com

For further information, please contact:
Johan Löf, President and CEO, RaySearch Laboratories AB (publ.)
Telephone: +46 (0)8-545 061 30
johan.lof@raysearchlabs.com