Paris, May 5, 2014 (GLOBE NEWSWIRE) -- Diaxonhit (Alternext : ALEHT) sponsored and organized with CareDx, Inc. (formerly XDx, Inc.) the first joint AlloMap Symposium during the annual ISHLT (International Society for Heart and Lung Transplantation) Conference that was held from April 10 to April 13, 2014 in San Diego, CA.
AlloMap is CareDx's flagship gene-expression profiling based blood test which is exclusively licensed to Diaxonhit for Europe. The test is a new method for regular and non-invasive surveillance of heart transplant recipients for acute cellular rejection, thereby contributing to patient follow-up optimization. AlloMap provides unique information regarding the body's immune response to a transplanted heart in the form of an objective numerical score.
During this Symposium chaired by Ulrich Jorde, MD, Columbia University, NY and Paul Mohacsi, MD, University of Bern, Bern, Switzerland, several presentations were made by European and US practitioners:
In parallel, four clinical abstracts (1) highlighting the clinical utility of AlloMap were delivered during the scientific sessions at the ISHLT conference, showing increased use of AlloMap in the United States as a clinical tool for surveillance of heart transplant recipients:
"This first Symposium jointly organized by Diaxonhit and CareDx was an opportunity to confirm the growing use of AlloMap in the United States, as much in daily practice as in research of new biomarkers for the surveillance of heart transplant patients. In the year of AlloMap's European launch, this growing interest is quite encouraging, especially when shared with European practitioners " stated Loïc Maurel, MD, President of Diaxonhit's Management Board.
(1) These studies describe uses of AlloMap that are currently under investigation and are not yet cleared by the FDA as safe and effective. The FDA's AlloMap Decision Summary is available at www.accessdata.fda.gov/cdrh_docs/reviews/k073482.pdf.
AlloMap Molecular Expression Testing is a non-invasive gene-expression test used to aid in the identification of heart transplant recipients with stable allograft function who have a low probability of moderate/severe acute cellular rejection at the time of testing in conjunction with standard clinical assessment. AlloMap testing measures the expression levels of 20 genes from a blood sample. The combined expression of these genes is represented as an AlloMap test score. AlloMap is performed in the CareDx CLIA-certified laboratory and has been commercially available in the United States since 2005. AlloMap was cleared by the U.S. Food and Drug Administration in 2008 and was CE marked for the European Union in 2011. Use of AlloMap is also included in the International Society for Heart and Lung Transplantation (ISHLT) Practice Guidelines, published in August 2010, the worldwide standard for the care of heart transplant patients.
Diaxonhit (NYSE Alternext, FR0004054427, ALEHT) is a French fully integrated leader in the in vitro diagnostic field, involved from research to commercialization of specialty diagnostic products.
With many partnerships and a strong presence in hospitals, Diaxonhit has an extensive commercialization network. Through its affiliate, InGen, it commercializes and services, mostly under exclusivity agreements, in vitro diagnostic kits and advanced equipment. It operates mainly in the fields of transplantation, infectious diseases and autoimmunity, product quality control and rapid tests, including Tetanus Quick Stick ®, a proprietary product. InGen is the leading supplier in France of HLA tests manufactured by Thermo-Fisher/One Lambda, of which it is the largest distributor worldwide.
The group also owns a diversified portfolio of products in development, including both innovative molecular and non-molecular diagnostics, covering three main specialty areas: transplantation, immuno-infection and cancer.
Diaxonhit headquarters are located in Paris and its affiliate in the Paris region. The Group is listed on NYSE Alternext in Paris and is part of the NYSE Alternext OSEO innovation index.
For more information, please visit: www.diaxonhit.com
CareDx, Inc., based in Brisbane, California, is a molecular diagnostics company focused on the discovery, development and commercialization of clinically differentiated, high value, non- invasive tests to monitor immune status in transplant recipients and autoimmune disease and potentially improve long-term patient outcomes. The company has commercialized AlloMap Gene Expression Testing, which aids physicians in determining the risk of acute cellular rejection in stable post-cardiac transplant patients. Some of the AlloMap technology developed by CareDx may be applicable to other conditions that involve transplant rejection and diseases that affect the immune system.
For more information, please visit: www.caredxinc.com.
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