Form 8 (OPD) AstraZeneca PLC

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| Source: AstraZeneca PLC
FORM 8 (OPD)

PUBLIC OPENING POSITION DISCLOSURE BY A PARTY TO AN OFFER

Rules 8.1 and 8.2 of the Takeover Code (the “Code”)

1.         KEY INFORMATION

+----------------------------------+------------------------------------------+
|(a) Identity of the party to the  |ASTRAZENECA PLC                           |
|offer making the disclosure:      |                                          |
+----------------------------------+------------------------------------------+
|(b) Owner or controller of        |N/A                                       |
|interests and short positions     |                                          |
|disclosed, if different from      |                                          |
|1(a):     The naming of nominee or|                                          |
|vehicle companies is insufficient |                                          |
+----------------------------------+------------------------------------------+
|(c) Name of offeror/offeree in    |ASTRAZENECA PLC (OFFEREE)                 |
|relation to whose relevant        |                                          |
|securities this form relates:     |                                          |
|Use a separate form for each party|                                          |
|to the offer                      |                                          |
+----------------------------------+------------------------------------------+
|(d) Is the party to the offer     |OFFEREE                                   |
|making the disclosure the offeror |                                          |
|or the offeree?                   |                                          |
+----------------------------------+------------------------------------------+
|(e) Date position held:           |12 MAY 2014                               |
+----------------------------------+------------------------------------------+
|(f)  Has the party previously     |YES: PFIZER INC. (OFFEROR)DISCLOSING TODAY|
|disclosed, or is it today         |                                          |
|disclosing, under the Code in     |                                          |
|respect of any other party to this|                                          |
|offer?                            |                                          |
+----------------------------------+------------------------------------------+

2.         POSITIONS OF THE PARTY TO THE OFFER MAKING THE DISCLOSURE

(a)        Interests and short positions in the relevant securities of the
offeror or offeree to which the disclosure relates

+------------------------------------------------+---------+-+---------------+-+
|Class of relevant security:                     |         | |               | |
+------------------------------------------------+---------+-+---------------+-+
|                                                |Interests| |Short positions| |
+------------------------------------------------+---------+-+---------------+-+
|                                                |Number   |%|Number         |%|
+------------------------------------------------+---------+-+---------------+-+
|(1) Relevant securities owned and/or controlled:|Nil      |0|Nil            |0|
+------------------------------------------------+---------+-+---------------+-+
|(2) Derivatives (other than options):           |Nil      |0|Nil            |0|
+------------------------------------------------+---------+-+---------------+-+
|(3) Options and agreements to purchase/sell:    |Nil      |0|Nil            |0|
+------------------------------------------------+---------+-+---------------+-+
|     TOTAL:                                     |Nil      |0|Nil            |0|
+------------------------------------------------+---------+-+---------------+-+

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase or
sell relevant securities, should be given on a Supplemental Form 8 (Open
Positions).

Details of any securities borrowing and lending positions or financial
collateral arrangements should be disclosed on a Supplemental Form 8 (SBL).

(b)        Rights to subscribe for new securities

+---------------------------------------------------------------------------+---
-+
|Class of relevant security in relation to which subscription right exists:
|None|
+---------------------------------------------------------------------------+---
-+
|Details, including nature of the rights concerned and relevant
percentages:|None|
+---------------------------------------------------------------------------+---
-+

If there are positions or rights to subscribe to disclose in more than one class
of relevant securities of the offeror or offeree named in 1(c), copy table 2(a)
or (b) (as appropriate) for each additional class of relevant security.

(c)        Irrevocable commitments and letters of intent

+-----------------------------------------------------------------------------+
|Details of any irrevocable commitments or letters of intent procured by the  |
|party to the offer making the disclosure or any person acting in concert with|
|it (see Note 3 on Rule 2.11 of the Code):                                    |
+-----------------------------------------------------------------------------+
|None                                                                         |
+-----------------------------------------------------------------------------+

3.         POSITIONS OF PERSONS ACTING IN CONCERT WITH THE PARTY TO THE OFFER
MAKING THE DISCLOSURE

+---------------------------------------------------------------------------+
|Details of any interests, short positions and rights to subscribe of any   |
|person acting in concert with the party to the offer making the disclosure:|
+---------------------------------------------------------------------------+

3(a)       Shares held by directors of AstraZeneca PLC

+-----------+-----------+--------------------------------------------+
|Director   |Number of  |Percentage of total issued share capital (%)|
|           |AstraZeneca|                                            |
|           |Shares     |                                            |
+-----------+-----------+--------------------------------------------+
|Pascal     |151,581    |0.01200826                                  |
|Soriot     |           |                                            |
+-----------+-----------+--------------------------------------------+
|Marc       |500        |0.00003961                                  |
|Dunoyer    |           |                                            |
+-----------+-----------+--------------------------------------------+
|Leif       |33,009     |0.002614976                                 |
|Johansson  |           |                                            |
+-----------+-----------+--------------------------------------------+
|Genevieve  |1,790      |0.000141804                                 |
|Berger     |           |                                            |
+-----------+-----------+--------------------------------------------+
|Bruce      |2,249      |0.000178166                                 |
|Burlington |           |                                            |
+-----------+-----------+--------------------------------------------+
|Ann Cairns |1,225      |0.000097044                                 |
+-----------+-----------+--------------------------------------------+
|Graham     |1,900      |0.000150518                                 |
|Chipchase  |           |                                            |
+-----------+-----------+--------------------------------------------+
|Jean       |2,635      |0.000208745                                 |
|-Philippe  |           |                                            |
|Courtois   |           |                                            |
+-----------+-----------+--------------------------------------------+
|Rudy       |2,452      |0.000194248                                 |
|Markham    |           |                                            |
+-----------+-----------+--------------------------------------------+
|Nancy      |2,643      |0.000209379                                 |
|Rothwell   |           |                                            |
+-----------+-----------+--------------------------------------------+
|Shriti     |3,000      |0.00023766                                  |
|Vadera     |           |                                            |
+-----------+-----------+--------------------------------------------+
|John Varley|9,500      |0.000752591                                 |
+-----------+-----------+--------------------------------------------+
|Marcus     |63,646     |0.005042042                                 |
|Wallenberg |           |                                            |
+-----------+-----------+--------------------------------------------+

3(b)      Directors’ interests in awards of AstraZeneca PLC shares under
AstraZeneca PLC’s share plans

Deferred Bonus Plan

+--------+-----------+-------------+-------------------+------------+
|Director|Number of  |Date of grant|Award price (pence)|Vesting date|
|        |AstraZeneca|             |                   |            |
|        |Shares     |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |3,799      |25/02/2013   |2939               |25/02/2016  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |15,966     |28/03/2014   |3904               |28/03/2017  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |2,679      |28/03/2014   |3904               |28/03/2017  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+

Performance Share Plan

+--------+-----------+-------------+-------------------+------------+
|Director|Number of  |Date of grant|Award price (pence)|Vesting date|
|        |AstraZeneca|             |                   |            |
|        |Shares     |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |125,113    |11/06/2013   |3297               |11/06/2016  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |124,066    |28/03/2014   |3904               |28/03/2017  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |90,853     |01/08/2013   |3302               |01/08/2016  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |52,254     |28/03/2014   |3904               |28/03/2017  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+

AstraZeneca Investment Plan

+--------+-----------+-------------+-------------------+------------+
|Director|Number of  |Date of grant|Award price (pence)|Vesting date|
|        |AstraZeneca|             |                   |            |
|        |Shares     |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |89,960     |11/06/2013   |3297               |01/01/2021  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |20,677     |28/03/2014   |3904               |01/01/2022  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |8,176      |01/08/2013   |3302               |01/01/2021  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |8,709      |28/03/2014   |3904               |01/01/2022  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+

Restricted Share Award

+--------+-----------+-------------+-------------------+------------+
|Director|Number of  |Date of grant|Award price (pence)|Vesting date|
|        |AstraZeneca|             |                   |            |
|        |Shares     |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |20,732     |26/10/2012   |2894               |01/10/2014  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Pascal  |20,732     |26/10/2012   |2894               |01/10/2015  |
|Soriot  |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+

Restricted Share Plan

+--------+-----------+-------------+-------------------+------------+
|Director|Number of  |Date of grant|Award price (pence)|Vesting date|
|        |AstraZeneca|             |                   |            |
|        |Shares     |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |9,103      |01/08/2013   |3302               |15/06/2014  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |41,472     |01/08/2013   |3302               |15/06/2015  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+
|Marc    |14,930     |01/08/2013   |3302               |01/08/2016  |
|Dunoyer |           |             |                   |            |
+--------+-----------+-------------+-------------------+------------+

3(c)       Interests of connected advisers

Goldman, Sachs & Co

Class of relevant security:                       USD 0.25 ordinary and ADRs
                                                  Interests      Short positions
                                                  Number   %     Number   %
(1) Relevant securities owned and/or controlled:  15,066   0.00  222,448  0.01
(2) Derivatives (other than options):             0        0.00  0        0.00
(3) Options and agreements to purchase/sell:      205,600  0.02  177,900  0.01
     TOTAL:                                       220,666  0.02  400,348  0.03

Morgan Stanley B.V.

Class of relevant         USD 0.25 ordinary and ADRs
security:
                          Interests       Short positions
                          Number  %       Number  %
(1) Relevant securities   0       0.00    0       0.00
owned and/or controlled:
(2) Derivatives (other    0       0.00    0       0.00
than options):
(3) Options and           6,883   0.00    0       0.00
agreements to
purchase/sell:
     TOTAL:               6,883   0.0005  0       0.00

3(d)      Interests of employment benefit trusts

+--------------------+-----------+----------------------------------------+
|Entity              |Number of  |Percentage of existing issued shares (%)|
|                    |AstraZeneca|                                        |
|                    |Shares     |                                        |
+--------------------+-----------+----------------------------------------+
|AstraZeneca Employee|1,051,810  |0.083324481                             |
|Share Trust Limited |           |                                        |
+--------------------+-----------+----------------------------------------+
|AstraZeneca Share   |100        |0.000007922                             |
|Trust Limited       |           |                                        |
+--------------------+-----------+----------------------------------------+

If there are positions or rights to subscribe to disclose in more than one class
of relevant securities of the offeror or offeree named in 1(c), copy table 3 for
each additional class of relevant security.

Details of any open derivative or option positions, or agreements to purchase or
sell relevant securities, should be given on a Supplemental Form 8 (Open
Positions).

Details of any securities borrowing and lending positions or financial
collateral arrangements should be disclosed on a Supplemental Form 8 (SBL).

4.         OTHER INFORMATION

(a)        Indemnity and other dealing arrangements

+-----------------------------------------------------------------------------+
|Details of any indemnity or option arrangement, or any agreement or          |
|understanding, formal or informal, relating to relevant securities which may |
|be an inducement to deal or refrain from dealing entered into by the party to|
|the offer making the disclosure or any person acting in concert with it:If   |
|there are no such agreements, arrangements or understandings, state “none”   |
+-----------------------------------------------------------------------------+
|None                                                                         |
+-----------------------------------------------------------------------------+

(b)        Agreements, arrangements or understandings relating to options or
derivatives

+-----------------------------------------------------------------------------+
|Details of any agreement, arrangement or understanding, formal or informal,  |
|between the party to the offer making the disclosure, or any person acting in|
|concert with it, and any other person relating to:(i)  the voting rights of  |
|any relevant securities under any option; or (ii) the voting rights or future|
|acquisition or disposal of any relevant securities to which any derivative is|
|referenced:If there are no such agreements, arrangements or understandings,  |
|state “none”                                                                 |
+-----------------------------------------------------------------------------+
|None                                                                         |
+-----------------------------------------------------------------------------+

(c)        Attachments

Are any Supplemental Forms attached?

+------------------------------------+---+
|Supplemental Form 8 (Open Positions)|YES|
+------------------------------------+---+
|Supplemental Form 8 (SBL)           |NO |
+------------------------------------+---+

+-------------------+------------------------------+
|Date of disclosure:|12 May 2014                   |
+-------------------+------------------------------+
|Contact name:      |Adrian Kemp, Company Secretary|
+-------------------+------------------------------+
|Telephone number:  |020 7604 8000                 |
+-------------------+------------------------------+

Public disclosures under Rule 8 of the Code must be made to a Regulatory
Information Service and must also be emailed to the Takeover Panel at
monitoring@disclosure.org.uk. The Panel’s Market Surveillance Unit is available
for consultation in relation to the Code’s dealing disclosure requirements on
+44 (0)20 7638 0129.

The Code can be viewed on the Panel’s website at www.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8(OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENT TO

PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the “Code”)

1.         KEY INFORMATION

     Identity of the person whose open       GOLDMAN, SACHS & CO.
positions are being disclosed:
     Name of offeror/offeree in relation to  ASTRAZENECA PLC (OFFEREE)
whose relevant securities disclosure
relates:

2.         OPTIONS AND DERIVATIVES

Class of  Product      Written    Number of      Exercise  Typee.g.   Expiry
relevant  description  or         securities to  price     American,  date
security  e.g.         purchased  which          per       European
          call option             option or      unit      etc.
                                  derivative
                                  relates
USD 0.25  Call Option  Sold       100            75.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Call Option  Sold       200            45.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       200            75.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  200            80.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  300            72.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       500            80.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  600            60.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       600            67.5000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  600            70.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Call Option  Sold       800            67.5000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       1,000          90.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  1,100          65.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       1,100          70.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  1,200          72.5000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       1,300          62.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Purchased  1,300          67.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       1,600          65.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       1,600          67.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  1,700          62.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       1,800          70.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  1,800          75.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  2,000          55.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Purchased  2,000          70.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  2,400          77.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       2,600          67.5000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  2,700          57.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       2,800          65.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Call Option  Purchased  2,800          72.5000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  2,900          77.5000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       3,100          60.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Call Option  Purchased  3,100          75.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  3,300          75.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       3,300          85.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  3,500          72.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  4,600          65.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  5,400          75.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       7,100          72.5000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       7,400          70.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Purchased  9,400          80.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Purchased  11,100         65.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       18,100         60.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Call Option  Sold       21,900         70.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Sold       32,500         80.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Call Option  Purchased  33,300         60.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  100            35.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  100            40.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  100            40.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Purchased  100            47.5000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Purchased  200            30.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       200            37.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  300            60.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  300            70.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       300            75.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       500            52.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       600            57.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       600            65.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       800            67.5000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       900            27.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       900            32.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       900            70.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  1,000          55.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  1,000          60.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  1,000          60.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  1,000          75.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       1,100          70.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       1,200          67.5000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       1,200          72.5000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Sold       1,300          40.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  2,100          30.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Purchased  2,100          50.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       2,100          65.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       2,300          52.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  2,400          35.0000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Purchased  2,600          57.5000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       2,600          65.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       3,100          67.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       3,600          70.0000   AMER       18/10/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       3,900          52.5000   AMER       15/01/2
ordinary                                         USD                  016
USD 0.25  Put Option   Sold       4,100          70.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  4,300          60.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       4,700          42.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  5,000          25.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  5,100          47.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  5,200          45.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Purchased  5,900          62.5000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  5,900          62.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  6,400          50.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       7,100          65.0000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  7,500          60.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       7,600          67.5000   AMER       21/06/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       8,400          65.0000   AMER       17/05/2
ordinary                                         USD                  014
USD 0.25  Put Option   Purchased  8,600          55.0000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       10,000         55.0000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       10,400         62.5000   AMER       17/01/2
ordinary                                         USD                  015
USD 0.25  Put Option   Sold       11,600         57.5000   AMER       19/07/2
ordinary                                         USD                  014
USD 0.25  Put Option   Sold       16,300         62.5000   AMER       21/06/2
ordinary                                         USD                  014

3.         AGREEMENTS TO PURCHASE OR SELL

Full details should be given so that the nature of the interest or position
can be fully understood:

It is not necessary to provide details on a Supplement form (Open Positions)
with regard to contracts for differences ("CFD") or spread bets

The currency of all pieces and other monetary amounts should be stated.

The Panel’s Market Surveillance Unit is available for consultation in relation
to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel’s website at www.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL
ETC.

Note 5(i) on Rule 8 of the Takeover Code (the “Code”)

1.         KEY INFORMATION

+--------------------------------------------+-------------------------+
|Identity of person whose open positions are |MORGAN STANLEY B.V.      |
|being disclosed:                            |                         |
+--------------------------------------------+-------------------------+
|Name of offeror/offeree in relation to whose|ASTRAZENECA PLC (OFFEREE)|
|relevant securities the disclosure relates: |                         |
+--------------------------------------------+-------------------------+

2.         OPTIONS AND DERIVATIVES

+--------+-----------+---------+-------------+---------+-------------+-------+
|Class of|Product    |Written  |Number of    |Exercise |Typee.g.     |Expiry |
|relevant|description|or       |securities to|price per|American,    |date   |
|security|e.g.       |purchased|which        |unit     |European etc.|       |
|        |call option|         |option or    |         |             |       |
|        |           |         |derivative   |         |             |       |
|        |           |         |relates      |         |             |       |
+--------+-----------+---------+-------------+---------+-------------+-------+
|USD 0.25|Call option|Written  |1,737        |SEK 336.9|European     |26/11/2|
|ordinary|           |         |             |         |             |015    |
+--------+-----------+---------+-------------+---------+-------------+-------+
|USD 0.25|Call option|Written  |610          |SEK 307.4|European     |23/11/2|
|ordinary|           |         |             |         |             |017    |
+--------+-----------+---------+-------------+---------+-------------+-------+
|USD 0.25|Call option|Written  |1,956        |SEK 301.9|European     |11/5/20|
|ordinary|           |         |             |         |             |16     |
+--------+-----------+---------+-------------+---------+-------------+-------+
|USD 0.25|Call option|Written  |2,580        |SEK 307.9|European     |23/10/2|
|ordinary|           |         |             |         |             |017    |
+--------+-----------+---------+-------------+---------+-------------+-------+

3.         AGREEMENTS TO PURCHASE OR SELL ETC.

+---------------------------------------------------------------------------+
|Full details should be given so that the nature of the interest or position|
|can be fully understood:                                                   |
+---------------------------------------------------------------------------+
|                                                                           |
+---------------------------------------------------------------------------+

It is not necessary to provide details on a Supplemental Form (Open Positions)
with regard to contracts for differences (“CFDs”) or spread bets.

The currency of all prices and other monetary amounts should be stated.

The Panel’s Market Surveillance Unit is available for consultation in relation
to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel’s website at www.thetakeoverpanel.org.uk.