AstraZeneca oncology pipeline update ahead of ASCO

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| Source: AstraZeneca PLC
ASTRAZENECA TO DEMONSTRATE THE STRENGTH AND
RAPID ACCELERATION OF ITS ONCOLOGY PIPELINE AT ASCO 2014

Preliminary data* released ahead of full data presentations at ASCO, 30 May-3
June

New data from AstraZeneca's investigational cancer medicines demonstrate the
rapid progression of its oncology pipeline. Over 40 scientific abstracts from
AstraZeneca and its global biologics R&D arm MedImmune will be featured at the
50th Annual Meeting of the American Society of Clinical Oncology (ASCO) at the
end of this month.

Data will be reported for a number of innovative molecules in different tumour
types. Highlights include:

  · In the MEDI4736 Phase I trial to date we have seen durable clinical activity
and acceptable safety for this investigational anti-PD-L1 antibody.

  · Data from the large Phase I study of AZD9291 has shown that it was well
tolerated and clinically active in patients with EGFR mutation positive (EGFRm+)
non-small cell lung cancer (NSCLC) who have developed acquired resistance to
EGFR tyrosine-kinase inhibitors (TKIs).

  · Encouraging efficacy data shown in a randomised Phase II study, conducted by
the US National Cancer Institute (NCI), investigating the combination of PARP
inhibitor olaparib and VEGF inhibitor cediranib in high-grade serous ovarian
cancer.

Briggs Morrison, Executive Vice President, Global Medicines Development and
Chief Medical Officer at AstraZeneca said: "We believe that our rich oncology
pipeline has the potential to redefine the way that cancer patients are treated.
We continue to deliver on our late stage assets and drive our scientific
leadership in oncology, as clearly demonstrated by the recent accelerated
development of key assets.

"The preliminary data made available today highlight our strength across our
three core areas of oncology research: immuno-oncology, our focus on the genetic
drivers of cancer and acquired resistance and DNA damage repair. We are looking
forward to the presentation of the full data sets at ASCO."

Harnessing the potential of immuno-oncology
MedImmune is building a comprehensive immuno-oncology programme, with MEDI4736
as one of the leading late stage assets. Data from the ongoing MEDI4736 Phase I
study to be presented at ASCO has to date shown encouraging clinical activity
and acceptable safety across a range of tumour types.

The results of this Phase I study, coupled with the pre-clinical data and
validation of this target supported the accelerated development of MEDI4736 into
Phase III clinical trials. The late stage clinical programme for MEDI4736 will
evaluate the compound in NSCLC at different stages of disease. Patients were
recently randomised into the Phase III PACIFIC study, which is investigating
patients with locally advanced unresectable NSCLC (Stage III) following
chemoradiation. A second Phase III study, ARCTIC, will investigate MEDI4736 as
monotherapy in patients with advanced or metastatic NSCLC who have failed on two
or more prior therapies, and planned in combination with tremelimumab.

Data from an ongoing study exploring MEDI4736 in combination with tremelimumab
in lung cancer will be presented as part of a briefing for analysts and
investors in Chicago on 2 June 2014.

MedImmune is also exploring tremelimumab (anti- CTLA 4) in a pivotal study for
malignant mesothelioma, a patient population with a very high unmet need.
Updated Phase II data from an investigator initiated trial exploring
tremelimumab in malignant mesothelioma will be available at ASCO.

"Immuno-oncology is developing at a rapid pace and redefining the cancer
treatment landscape. We are committed to realising the full potential of this
promising therapeutic approach," said Bahija Jallal, Executive Vice President,
MedImmune. "We believe that combinations of immunotherapies, both with each
other and with highly targeted small molecules, will be the key to achieving the
greatest patient benefit. With the AstraZeneca and MedImmune combined portfolio,
we are uniquely positioned to explore this possibility and have already
initiated multiple combination studies with MEDI4736."

Two oral presentations and a poster highlights session will showcase data from
the Phase I study (abstract #3001 in patients with solid tumours, abstract
#3002, a multi-arm expansion study and abstract #8021, a clinical activity and
biomarker analysis of MEDI4736 in patients with treatment-naïve or pre-treated
NSCLC).

Targeted treatments in lung cancer
Despite the efficacy of currently approved TKIs, for patients who have the EGFR
mutation positive form of NSCLC, resistance to treatment is a significant
barrier to long term disease control. In approximately half of these patients
this resistance is caused by the secondary mutation known as T790M and there are
currently no therapies specifically approved for them. AZD9291 is a highly
selective, irreversible inhibitor of both the activating sensitising EGFR
mutation (EGFRm+) and the activating resistance mutation, T790M, while sparing
the activity of wild type EGFR.

Updated data from the ongoing Phase I AURA study show that to date AZD9291 is
well tolerated and has demonstrated sustainable anti-cancer activity in lung
cancer patients whose tumours are EGFR mutation positive and have become
resistant to EGFR TKIs. Specifically, the data from this trial demonstrate that
patients with EGFR T790M+ tumours have a higher overall response rate than
patients whose tumours have not acquired this resistance mutation. The data will
be presented as an oral abstract (abstract #8009) and was selected from over
5,000 study abstracts for inclusion in the official ASCO programme.

AZD9291 was recently granted Breakthrough Therapy Designation by the US FDA for
patients with metastatic EGFR T790M mutation-positive NSCLC, whose disease has
progressed following treatment with an EGFR TKI. The Breakthrough designation
allows AstraZeneca to expedite the US development of AZD9291. AstraZeneca plans
to begin Phase III trials soon.

Driving the potential of combinations
Combination therapies have the potential to be one of the most effective ways of
treating cancer. Results from the NCI led Phase II study investigating the
combination of olaparib, a potential first-in-class oral poly ADP-ribose
polymerase (PARP) inhibitor, and cediranib, a potent inhibitor of vascular
endothelial growth factor (VEGF) receptor tyrosine kinases, in women with
ovarian cancer will be presented as a Late Breaking Abstract (abstract LBA5500).

Olaparib has already shown efficacy as a monotherapy and was recently granted
Priority Review by the FDA for the treatment of platinum sensitive relapsed
ovarian cancer patients who have a BRCA mutation. Additionally, in the Phase III
(ICON 6) trial, cediranib demonstrated significant improvements in progression
free survival and overall survival in platinum sensitive relapsed ovarian
cancer, when given during and after chemotherapy, compared to chemotherapy
alone.

During the ASCO conference AstraZeneca will host a briefing for analysts and
investors, to be held in Chicago on 2 June 2014.

KEY ASTRAZENECA ABSTRACTS TO BE FEATURED AT ASCO

* Data included in abstracts is preliminary only and does not necessarily
represent full data sets.

Oral presentations, included in official programme:

  · #3001 Lutzky J, et al. A Phase 1 study of MEDI4736, an Anti-PD-L1 Antibody,
in Patients With Advanced Solid Tumors. Oral presentation, 09.57am - 10.09am 3
June 2014.
  · #3002 Segal NH, et al. Preliminary Data from a Multi-Arm Expansion Study of
MEDI4736, an Anti-PD-L1 Antibody. Oral presentation, 10.09am - 10.21am 3 June
2014.
  · #8009 Janne P, et al. Clinical activity of the mutant selective EGFR
Inhibitor AZD9291 in patients (pts) with EGFR inhibitor resistant non-small cell
lung cancer (NSCLC). Oral presentation 8.00am - 8.12am 31 May 2014.

Late breaking abstract:

  · #LBA5500 Liu JF, et al. A randomized phase 2 trial comparing efficacy of the
combination of the PARP inhibitor olaparib and the anti-angiogenic cediranib
against olaparib alone in recurrent platinum-sensitive ovarian cancer. Oral
presentation 1:15 PM - 1:27 PM 31 May 2014.

Other key MEDI4736 abstracts to be featured:

  · #TPS3120^ Callahan MK, et al. A phase 1 study to evaluate the safety and
tolerability of MEDI4736, an anti-PD-L1 antibody, in combination with
tremelimumab in patients with advanced solid tumours. General poster session
8:00 AM - 11:45 AM 1 June 2014.
  · #TPS9108 Gordon MS, et al. Phase 1 study of MEDI4736, an anti-PD-L1
antibody, in combination with dabrafenib and trametinib or trametinib alone in
patients with unresectable or metastatic melanoma. General poster session 8:00
AM - 11:45 AM 31 May 2014.
  · #3012 Hyman D, et al. A phase 1 study of MEDI3617, a selective angiopoietin
-2 inhibitor, alone and in combination with carboplatin/paclitaxel, paclitaxel,
or bevacizumab in patients with advanced solid tumors. General poster session
1:15 PM - 4:15 PM 2 June 2014.
  · #8021 Brahmer J, et al. Clinical activity and biomarkers of MEDI4736, an
anti-PD-L1 antibody, in patients with NSCLC. Poster highlights session 8:00 AM -
11:00 AM 3 June 2014.
  · #2602 Fairman D, et al. Pharmacokinetics of MEDI4736, a fully human anti
-PDL1 monoclonal antibody, in patients with advanced solid tumours. General
poster session 8:00 AM - 11:45 AM 1 June 2014.

Other key AZD9291 abstract to be featured:

  · #8092 Thress K, et al. EGFR mutation detection in ctDNA isolated from NSCLC
patient plasma; a cross-platform comparison of leading technologies to support
the clinical development of AZD9291. General poster session 1:15 PM - 5:00 PM 31
May 2014.

Other key olaparib abstracts to be featured:

  · #TPS5616 Moore K, et al. SOLO1 and SOLO2: Randomized phase III trials of
olaparib in patients (pts) with ovarian cancer and a BRCA1/2 mutation (BRCAm).
General poster session 8:00 AM - 11:45 AM 31 May 2014.
  · #2599 Vergote I, et al. Effect of food on the pharmacokinetics (PK) of
olaparib after oral dosing of the capsule formulation. General poster session
8:00 AM - 11:45 AM 1 June 2014.
  · #5534 Lheureux S, et al. Characterization of ovarian cancer long-term
responders on olaparib. General poster session 8:00 AM - 11:00 AM 2 June 2014.
  · #5536 Dougherty B, et al. Analysis of candidate homologous repair deficiency
genes in a clinical trial of olaparib in patients (pts) with platinum-sensitive,
relapsed serous ovarian cancer (PSR SOC). Poster Highlights session 8:00 AM -
11:00 AM 2 June 2014.

Other abstracts to be featured:

  · #11111 Gan H, et al. First-in-human phase I study of a selective c-Met
inhibitor volitinib (HMP504/AZD6094) in patients with advanced solid tumors
General Poster Session 1:15 PM - 5:00 PM 31 May 2014.
  · #2510 Matulonis U, et al. Phase I study of oral BKM120 and oral olaparib for
high-grade serous ovarian cancer (HGSC) or triple-negative breast cancer (TNBC).
Oral presentation 8:12 AM - 8:24 AM 31 May 2014 (ISS)
  · #2607 Banerji U, et al. TAX-TORC: A phase I trial of the combination of
AZD2014 (dual mTORC1/mTORC2 inhibitor) and weekly paclitaxel in patients with
solid tumours. General poster session 8:00 AM - 11:45 AM 1 June 2014

About MEDI4736
MEDI4736 is an investigational, engineered, human monoclonal antibody directed
against programmed cell death ligand 1 (PD-L1). Signals from PD-L1 help tumours
avoid detection by the immune system. It is believed that by targeting PD-L1,
MEDI4736 may block this ligand from sending out a signal to T cells to 'ignore'
tumour cells, thereby countering cancer's immune-evading tactics. MEDI4736 is
being developed alongside other immunotherapies (IMTs) - which
AstraZeneca/MedImmune believe have the potential to shape the future of cancer
treatment - particularly if used in combination with other highly-active
molecules.

About tremelimumab
Tremelimumab is an investigational, fully human monoclonal IgG2 antibody which
binds to the protein CTLA-4, expressed on the surface of activated T cells. It
is one of the only molecules in development for treating mesothelioma by
blocking CTLA-4 to strengthen immune system response.

About AZD9291
AZD9291 is a highly selective, irreversible inhibitor of both the activating
sensitising EGFR mutation (EGFRm+) and the activating resistance mutation,
T790M, while sparing the activity of wild type EGFR. Patients with EGFRm+ NSCLC
are particularly sensitive to treatment with currently available EGFR TKIs,
which block the cell signalling pathways that drive the growth of tumour cells.
However, tumour cells almost always develop resistance to treatment, leading to
disease progression. In approximately half of patients, this resistance is
caused by the secondary mutation known as T790M. There are currently no targeted
therapies approved for the treatment of tumours with this resistance mutation.

In the ongoing Phase I study, AZD9291 has shown early evidence of activity as a
once-daily monotherapy with clinical responses observed in an EGFRm+ population
of patients with NSCLC who have previously failed on EGFR TKIs and also in
patients with the T790M mutation. To date, AZD9291 has been well-tolerated with
low rates of side effects.

About olaparib
Olaparib is a potential first-in-class oral poly ADP-ribose polymerase (PARP)
inhibitor that has been shown to exploit DNA repair pathway deficiencies to
preferentially kill cancer cells. This mode of action gives olaparib the
potential for development in a range of tumour types with DNA repair
deficiencies. PARP is a key enzyme in one of the DNA repair pathways in human
cells. Inhibition of PARP results in a build-up of DNA damage in the cell,
requiring repair via an alternative pathway called Homologous Recombination
repair (HR). Cancer cells that already have a deficient HR pathway (HRD) are
limited in their ability to repair their DNA, overloading them with DNA damage
and causing them to die. A number of abnormalities can cause HRD in cancer cells
including BRCA gene mutations. PARP is associated with a range of tumour types,
in particular with breast and ovarian cancers.

The US Food and Drug Administration (FDA) has granted Priority Review for
olaparib, in the treatment of ovarian cancer patients who have a BRCA mutation
and whose cancer has relapsed following a complete or partial response to
platinum-based chemotherapy.

About cediranib
Cediranib is a potent selective oral inhibitor of cell signalling through
Vascular Epidermal Growth Factor (VEGF) receptors, resulting in tumour cell
death by restricting blood supply to the tumour site.

Angiogenesis, the formation of new blood vessels, is essential for normal
biologic processes such as wound healing and the renewal of the uterine lining.
However, angiogenesis can also facilitate cancer growth and metastasis by
supporting the development of new blood vessels that then supply the tumour with
nutrients and oxygen. Angiogenesis therefore constitutes an important point in
the control of cancer progression and its inhibition has become a valuable
approach to treatment for multiple cancers. Angiogenesis is highly dependent on
the vascular endothelial growth factor (VEGF) signalling pathway. VEGF and VEGF
receptors (VEGFRs) are often over expressed in cancer and are associated with a
poor prognosis. Inhibiting VEGF signalling interferes with this process,
effectively "starving" the tumour of the oxygen and nutrients it needs to grow.

Cediranib is currently being evaluated in an ongoing clinical development
programme, including studies in multiple tumours.

About MedImmune
MedImmune is the worldwide biologics research and development arm of
AstraZeneca. MedImmune is pioneering innovative research and exploring novel
pathways across key therapeutic areas, including respiratory, inflammation and
autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and
infection and vaccines. The MedImmune headquarters is located in Gaithersburg,
Md., one of AstraZeneca's three global R&D centres. For more information, please
visit www.medimmune.com.

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that
focuses on the discovery, development and commercialisation of prescription
medicines, primarily for the treatment of cardiovascular, metabolic,
respiratory, inflammation, autoimmune, oncology, infection and neuroscience
diseases. AstraZeneca operates in over 100 countries and its innovative
medicines are used by millions of patients worldwide. For more information
please visit: www.astrazeneca.com

CONTACTS

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14 May 2014

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