First PBS / IMPT proton treatments with RayStation

| Source: RaySearch Laboratories AB
Provision Center for Proton Therapy treats first patients in Tennessee with the
RayStation® treatment planning system from RaySearch Laboratories AB.
On May 27, 2014 the first patient was treated with the Pencil Beam Scanning
(PBS) treatment technique at the Provision Center for Proton Therapy in
Knoxville, Tennessee, the state’s first and only proton therapy treatment
facility. The clinical patient treatment plans were created entirely on
RayStation®, RaySearch’s highly advanced treatment planning and dose tracking
software platform and delivered on the IBA proton system.

PBS is the most sophisticated delivery technique in proton therapy. It enables
Intensity Modulated Proton Therapy (IMPT) that allows clinicians to target a
cancerous tumor by controlling both the intensity and the spatial distribution
with millimeter precision. Earlier this year, the first patients were treated
using the Uniform Scanning technique at Provision.

The proton center opened less than two years after breaking ground in April
2012. A 220-ton cyclotron, a particle accelerator that produces protons, was
installed a year ago in January 2013 at the center, which sits on the 120-acre
comprehensive outpatient medical campus at Dowell Springs in Knoxville. In close
collaboration with RaySearch, Provision was able to get the treatment planning
network installed, have data collected and modeled, perform extensive quality
assurance and train their entire staff in only four months. “We knew this was an
aggressive timeline, but we were very confident in the technologies that we had
selected, and also in the people that were focused on the project. Providing
this region with proton therapy as an option for cancer treatment is a vision
that our organization has tirelessly pursued. We are pleased with results and
happy with our selection of RaySearch as our partner,” said Niek Schreuder, the
VP and Chief of Medical Physics for the center.

“The Provision Center for Proton Therapy is a model for what can be achieved
when people from multiple organizations come together and work towards a common
goal. Niek and his team brought a lot of knowledge and expertise to the table
and implemented a cutting edge program safely and efficiently,” says Marc Mlyn,
President of RaySearch Americas, Inc. “We are pleased that this was the first
site in the USA that implemented RayStation® clinically for proton therapy –
both for Uniform Scanning and PBS.”

“Provision has a culture for excellent patient care and takes pride in being at
the forefront of leading-edge technologies,” said Marcio Fagundes, M.D., board
-certified radiation oncologist and Medical Director at the Provision Center for
Proton Therapy. “The Provision Center for Proton Therapy is an example of such
commitment. Provision selected RayStation® with the expectation that it would
improve efficiency and provide excellence in patient planning. RayStation® has
not only achieved these expectations but has changed the landscape of all
planning environments currently in practice.”

“Proton therapy is a prioritized area for us and we have worked very hard to
create the leading solution for proton treatment planning with support for all
treatment modalities. It is of course a historical event for us that RayStation®
has now been implemented clinically for proton therapy using the PBS treatment
technique meaning that the system is used to create the most advanced cancer
radiation treatments available”, says Johan Löf, CEO of RaySearch.

The current version of RayStation® that has FDA clearance supports all relevant
proton treatment techniques such as Uniform Scanning, Double Scattering and PBS

About Provision Center for Proton Therapy
Provision Center for Proton Therapy is the first cancer treatment center of its
kind in Tennessee and only the second in the Southeastern United States. Open to
all credentialed physicians and health systems in the region, the Provision
Center for Proton Therapy will have three treatment rooms and will be able to
treat up to 900 cancer patients annually, and will bring in many patients from
outside the area. Treatments will typically require daily 30 - 45 minute
sessions for two months. The next closest location offering proton therapy is
350 miles away. The center brings to Knoxville an advanced cancer treatment
capability that presently is available in only a handful of cities. It is one of
only 14 in the nation and 46 in the world.

About RayStation®
RayStation® integrates all RaySearch’s advanced treatment planning solutions
into a flexible treatment planning system. It combines unique features such as
multi-criteria optimization tools with full support for 4D adaptive radiation
therapy. It also includes functionality such as RaySearch’s market-leading
algorithms for IMRT and VMAT optimization and highly accurate dose engines for
photon, electron and proton therapy. The system is built on the latest software
architecture and has a graphical user interface offering state-of-the-art

About RaySearch
RaySearch Laboratories is a medical technology company that develops advanced
software solutions for improved radiation therapy of cancer. RaySearch provides
the RayStation® treatment planning system to clinics all over the world. In
addition, RaySearch’s products are distributed through licensing agreements with
leading partners such as Philips, Nucletron, IBA, Varian and Brainlab. To date,
15 products have been launched via partners and RaySearch’s software is used by
over 2,500 clinics in more than 65 countries. RaySearch was founded in 2000 as a
spin-off from the Karolinska Institute in Stockholm and the company is listed in
the Small Cap segment on NASDAQ OMX Stockholm.

For more information about RaySearch, visit

For further information, please contact:
Johan Löf, President and CEO, RaySearch Laboratories AB
Telephone: +46 (0)8-545 061 30