Holding(s) in Company


+-------------+-++++--------------+
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+-------------+-++++--------------+
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+-------------+-++++--------------+
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+-------------+-++++--------------+
|TR-1:                            |
|NOTIFICATION OF                  |
|MAJOR INTEREST                   |
|IN SHARESi                       |
+-------------+-++++--------------+
|                 |               |
+-------------+-++++--------------+
|1. Identity of   |AstraZeneca PLC|
|the issuer or    |               |
|the              |               |
|underlying       |               |
|issuer of        |               |
|existing shares  |               |
|to which voting  |               |
|rights           |               |
|are attached:ii  |               |
+-------------+-++++--------------+
|2 Reason for                     |
|the                              |
|notification                     |
|(please tick                     |
|the                              |
|appropriate box                  |
|or boxes):                       |
+-------------+-++++--------------+
|An acquisition    |Yes           |
|or disposal of    |              |
|voting rights     |              |
+-------------+-++++--------------+
|An acquisition    |No            |
|or disposal of    |              |
|qualifying        |              |
|financial         |              |
|instruments       |              |
|which may         |              |
|result in the     |              |
|acquisition of    |              |
|shares already    |              |
|issued to which   |              |
|voting rights     |              |
|are attached      |              |
+-------------+-++++--------------+
|An acquisition    |No            |
|or disposal of    |              |
|instruments       |              |
|with similar      |              |
|economic effect   |              |
|to qualifying     |              |
|financial         |              |
|instruments       |              |
+-------------+-++++--------------+
|An event          |No            |
|changing the      |              |
|breakdown of      |              |
|voting rights     |              |
+-------------+-++++--------------+
|Other (please|    |              |
|pecify):     |    |              |
+-------------+-++++--------------+
|3. Full name of|Invesco          |
|person(s)      |Limited          |
|subject to     |                 |
|the            |                 |
|  notification |                 |
|obligation: iii|                 |
+-------------+-++++--------------+
|4. Full name of|                 |
|shareholder(s) |                 |
|  (if different|                 |
|from 3.):iv    |                 |
+-------------+-++++--------------+
|5. Date of the |17               |
|transaction and|April            |
|date   on      |2014             |
|  which the    |                 |
|threshold is   |                 |
|crossed or     |                 |
|  reached:   v |                 |
+-------------+-++++--------------+
|6. Date on     |17 June          |
|which issuer   |2014             |
|notified:      |                 |
+-------------+-++++--------------+
|7. Threshold(s)|5%               |
|that is/are    |                 |
|crossed   or   |                 |
|  reached: vi, |                 |
|  vii          |                 |
+-------------+-++++--------------+
|             | ||||              |
+-------------+-++++--------------+

+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|8. Notified details:
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|A: Voting rights attached to shares viii, ix
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Class/type of    |Situation previous                   |Resulting situation
after the triggering transaction                                          |
|shares           |to the triggering                    |
|
|                 |transaction                          |
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|if possible using|Number         |Number               |Number
|Number of voting      |% of voting rights x                              |
|the ISIN CODE    |of             |of                   |of shares
|rights                |                                                  |
|                 |Shares         |Voting               |                      |
|                                                  |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|                 |               |Rights               |Direct
|Direct xi|Indirect xii|Direct                       |Indirect            |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Ordinary Shares  |72,920,319     |72,920,319           |                      |
|63,033,761  |                             |4.99%               |
|                 |               |                     |                      |
|            |                             |                    |
|GB0009895292     |               |                     |                      |
|            |                             |                    |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|B: Qualifying Financial Instruments
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Resulting situation   after the triggering transaction
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Type of financial  |Expiration             |Exercise/  Conversion Period xiv
|Number of voting                              |% of voting              |
|instrument         |date xiii              |
|rights that may be                            |rights                   |
|                   |                       |
|acquired if the                               |                         |
|                   |                       |
|instrument is                                 |                         |
|                   |                       |
|exercised/ converted.                         |                         |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|                   |                       |
|                                              |                         |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|C: Financial Instruments with   similar economic effect to Qualifying Financial
Instruments xv, xvi                                                     |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Resulting situation   after the triggering transaction
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Type of financial |Exercise price|Expiration date xvii|Exercise/
|Number of voting   rights instrument refers to|% of voting rights xix, xx|
|instrument        |              |                    |Conversion period xviii|
|                          |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|                  |              |                    |                       |
|Nominal|Delta             |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|                  |              |                    |                       |
|       |                  |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Total (A+B+C)
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|Number of voting   rights                               |Percentage of   voting
rights                                                                  |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|63,033,761                                              |4.99%
|
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+
|                 |||             |         |          |||
||        |            |                       ||    | |                  |
+-----------------+++-------------+---------+----------+++--------------------
-++--------+------------+-----------------------++----+-+------------------+

+-----------------------------+---------------------+---------------------------
-+
|9. Chain of controlled undertakings   through which the voting rights and/or
the|
|  financial instruments are effectively held, if applicable: xxi
|
+-----------------------------+---------------------+---------------------------
-+
|Invesco Advisers Inc. – 182,047
|
|Invesco Asset Management Japan – 75,034
|
|Invesco Asset Management Limited – 16,790,150
|
|Invesco Asset Management S.A (France) – 76,196
|
|Invesco PowerShares Capital Management LLC – 158,278
|
|Invesco GT Management Ltd – 39,146
|
|Invesco Hong Kong Limited – 1,155
|
|Invesco Fund Managers Limited – 45,006,926
|
|Invesco Asset Management Limited GmbH – 667,087
|
|Van Kampen Asset Management – 37,742
|
+-----------------------------+---------------------+---------------------------
-+
|
|
+-----------------------------+---------------------+---------------------------
-+
|Proxy Voting:
|
+-----------------------------+---------------------+---------------------------
-+
|10. Name of the proxy holder:                      |      Invesco Limited
|
+-----------------------------+---------------------+---------------------------
-+
|11. Number of voting rights proxy holder will cease|            N/A
|
|  to hold:                                         |
|
+-----------------------------+---------------------+---------------------------
-+
|12. Date on which proxy holder will cease to hold  |            N/A
|
|  voting rights:                                   |
|
+-----------------------------+---------------------+---------------------------
-+
|
|
+-----------------------------+---------------------+---------------------------
-+
|13. Additional information:  |
|
|                             |
|
+-----------------------------+---------------------+---------------------------
-+
|14. Contact name:            |                   Sam Edwards
|
+-----------------------------+---------------------+---------------------------
-+
|15. Contact telephone number:|                   01491 416381
|
+-----------------------------+---------------------+---------------------------
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|                             |                     |
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Attachments

06181577.pdf