Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 1 August 2014, Leif Johansson, a Director of the Company notified us that, on
1 August 2014, he sold and purchased AstraZeneca PLC Ordinary Shares of $0.25
each.

As a result of these transactions, Mr Johansson has increased his total interest
by 6,000 AstraZeneca shares.

Mr Johansson holds some of his AstraZeneca shares in pension arrangements in
Sweden. One part of these arrangements has closed, resulting in the sale of
shares. In order to maintain his interest in AstraZeneca shares, Mr Johansson
has reinvested the sale proceeds.

Details of the sale and purchase are as follows:

1,000 shares sold at a price of SEK 503.00 per share.

1,000 shares purchased at a price of SEK 503.00 per share.

In addition, on 1 August 2014, Mr Johansson purchased a further 6,000 shares at
a price of SEK 502.95 per share.

On 31 July 2014, certain other Directors of the Company notified us that, on 31
July 2014, they purchased AstraZeneca PLC Ordinary Shares of $0.25 each, as
follows:

Name of Director  Number of shares purchased  Purchase price
Geneviève Berger  300                         4324p
Shriti Vadera     3,500                       4328p
John Varley       3,500                       4370p

A C N Kemp
Company Secretary
1 August 2014