Recipharm forms new collaboration with Isofol Medical to exclusively manufacture Modufolin® and invests SEK 8 million in the company

Recipharm and Isofol Medical AB, a Gothenburg-based pharmaceutical company
developing novel products for unmet needs within oncology, are pleased to
announce the formation of a collaboration to strengthen the development program
of Isofol’s lead drug candidate Modufolin®.
At the same time, Recipharm Venture Fund, the life science sector investor with
a strategic interest in pharmaceutical and biotechnology companies in need of
pharmaceutical development and manufacturing support, has today announced that
it has invested SEK 8 million in Isofol Medical.

Isofol Medical AB is currently evaluating Modufolin® in two clinical phase I/II
studies. Modufolin® is an endogenous folate-based biomodulator, developed to
increase the efficacy and decrease the side effects of chemotherapeutic agents
used in the treatment of solid tumors. Modufolin® is innovative and has very
good sales potential and a high likelihood of reaching the market.

Carl-Johan Spak, EVP Development & Technology, Recipharm, commented: “We are
very pleased to have further developed our collaborative partnership with Isofol
Medical and to have now signed an agreement for future exclusive commercial
manufacturing of Modufolin®, especially as this is a new, innovative drug,
focused on tumor treatment and consequently has strong sales potential.”

He continued: “We look forward to putting our technical skills and capabilities
to fully manufacture this exciting product whilst further assisting its
development through the strategic investment.”

“Given the promising clinical data we have obtained to date we want to secure
the long term manufacture and supply of Modufolin® for its future
commercialization. With Recipharm’s investment of 8 MSEK in Isofol we have now
raised 45 MSEK during the last 8 months. This capital and the collaboration with
Recipharm not only strengthens the ongoing Phase II clinical development program
but could also secure the future commercialization of Modufolin®” Anders Rabbe,
Managing Director of Isofol commented.

For more information contact:
Carl-Johan Spak, EVP Development & Technology Recipharm
carl-johan.spak@recipharm.com, +46 8 602 53 13


Anders Rabbe, Managing Director, Isofol Medical
anders.rabbe@isofolmedical.com, +46 (0)707 646 500

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About Recipharm
Recipharm is a leading CDMO (Contract Development and Manufacturing
Organisation) in the pharmaceutical industry based in Sweden employing some
1,500 employees. Recipharm offers manufacturing services of pharmaceuticals in
various dosage forms, production of clinical trial material and pharmaceutical
product development. Recipharm currently manufactures more than 200 different
products to both Big Pharma and smaller research- and development companies.
Recipharm’s turnover is approximately SEK 2.1 billion and the Company operates
development and manufacturing facilities in Sweden, France, the UK, Germany and
Spain and is headquartered in Jordbro, Sverige. The Recipharm B-share (RECI B)
is listed on Nasdaq OMX Stockholm.
For more information on Recipharm and our services, please visit
www.recipharm.com.

About Modufolin®
Modufolin® (chemical name [6R]-5,10-methylenetetrahydrofolate), is a novel
folate-based compound developed to increase the efficacy and reduce the side
effects of antimetabolites used in cancer treatment. Modufolin® is the key
active metabolite of all clinically used folate-based drugs used today including
Leucovorin and Levoleucovorin. Modufolin does not require metabolic activation.
It has therefore the potential to benefit all patients irrespective of their
capacity to activate folates, whereas today’s folate-based drugs must be
activated by the body. Modufolin® is currently being evaluated in clinical Phase
II studies for colorectal cancer and osteosarcoma.

Modufolin® is a registered Trademark of Merck KGaA, Darmstadt, Germany.

About Isofol Medical AB
Isofol Medical is a clinical stage pharmaceutical company developing novel
products for unmet needs within oncology. Isofol’s lead clinical candidate,
Modufolin®, is predicted to improve the outlook for cancer patients undergoing
chemotherapy treatment with a range of antimetabolites. Isofol’s ongoing
clinical trials are focusing on colorectal cancer and osteosarcoma. Isofol
Medical collaborates closely with its strategic R&D partner Merck Millipore, the
world’s leading manufacturer of reduced folates.

For more information about Isofol Medical, please visit www.isofolmedical.com
Recipharm AB (publ)
Corporate identity number 556498-8425
Address Lagervägen 7, SE-136 50 Jordbro Telephone 46 8 602 52 00
Fax 46 8 81 87 03, www.recipharm.com