Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 10 November 2014, Luke Miels, EVP, Global Product and Portfolio Strategy, a
person discharging managerial responsibilities, notified us that, on 7 November
2014, Mrs Jane Miels, a person connected with him, purchased 10,500 AstraZeneca
PLC Ordinary Shares of $0.25 each at a price of 4614.5 pence per share.
A C N Kemp
Company Secretary
10 November 2014