ONXEO Launches a Rights Issue with Shareholder Preferential Subscription Rights, for a Maximum Amount of up to €41.6 Million...


Rights Issue Open to the Public in France and in Denmark

Transaction Executed on the Back of Subscription Commitments from the Company's
Principal Shareholder, Financiere De La Montagne, and Two Other International
Investors, Securing Fully the Offering Size

Issue Price of €4.50 Per Share with a Parity of 1 New Share for 4 Existing
Shares

Subscription Period: from November 24 to December 3, 2014 Inclusive
PARIS & COPENHAGEN--(BUSINESS WIRE (http://www.businesswire.com/))-- Regulatory
News:

Onxeo SA (Paris:ONXEO) (NASDAQ OMX:ONXEO) (Euronext Paris, Nasdaq OMX Copenhagen
– ONXEO or “the Company”), an innovative biopharmaceutical company specialized
in the development of orphan oncology drugs, created by the merger of
BioAlliance Pharma and Topotarget in July 2014, announces today in France and in
Denmark the launch of a rights issue with shareholder preferential subscription
rights for a gross amount of €35.4 million. This amount may be increased to a
maximum of €41.6 million upon exercise of all financial instruments giving
access to share capital in the Company before November 26, 2014 and of the
extension clause. Based on the subscription commitments, the extension clause
will be exercised by at least 682,894 shares, increasing the offering size to at
least €38.5 million (excluding exercise of financial instruments before November
26, 2014).

Rights issue rationale

ONXEO targets to become a global leader in oncology, with a focus on orphan or
rare cancers, leveraging its three key programs already at an advanced
development stage, Beleodaq® (an approved histone deacetylase inhibitor (HDAC)
commercialized in the US by partner Spectrum Pharmaceuticals for the treatment
of peripheral T-cell lymphoma), Livatag® (a doxorubicin nano-formulation for the
treatment of primary liver cancer, currently in a phase III clinical trial) and
Validive® (a mucoadhesive clonidine tablet that has shown efficacy in a Phase II
clinical trial in the treatment of severe oral mucositis in patients treated for
a head and neck cancer).

These high value-added programs focus on significant and unsatisfied medical
need showing strong sales potential.

The proceeds of the offering (excluding offsetting receivables) are mainly
intended to finance research and development on key Company products, as well as
its current requirements and in particular to:

  · support the international expansion of Livatag's® phase III by broadening
the ReLive study into new areas to increase the recruitment rate and optimise
the study's duration,
  · prepare Validive's® Phase III study, which follows Phase II, for which the
first results were obtained on October 30, 2014,
  · pursue Beleodaq's® next development stage involving:
    · a Phase I combination study with the standard treatment for the PTCL
indication as a first line treatment, and
    · preparing for the start of Phase III in order to validate the Marketing
Authorisation in the United States for this indication and to obtain the same
authorisation in Europe.

« 2014 was a cornerstone year for BioAlliance, which became ONXEO last August,
with a deep strategic move, major progress in its key development programs and
an enlarged European dimension through Topotarget acquisition.

This rights issue will allow us to pursue this step-up, by accelerating and
expanding development programs which are the base of ONXEO value. » (Judith
Greciet, CEO of ONXEO).

Rights issue main terms

This capital increase with shareholder preferential subscription rights will
result in the issuance of 7,872,661 new shares at a price of €4.50 per share,
for a gross amount, including share premium of €35,426,974.50. This number of
new shares may be increased to a maximum of 9,246,098 shares upon exercise of
all financial instruments giving access to share capital in the Company before
November 26, 2014 and of the extension clause, resulting in a maximum gross
amount of €41,607,441.

On November 24, 2014, each Company’s shareholder will receive one preferential
subscription right per share registered on its holder’s share-account at the end
of the accounting day on November 21, 2014. The subscription price for the new
shares has been set at €4.50 per share (comprising a nominal value of €0.25 and
a share premium of €4.25) on the basis of a ratio of 1 new share for 4 existing
shares (4 rights to be exercised for the subscription of 1 new share).

On an indicative basis, taking into account the closing price of ONXEO on the
regulated market of Euronext Paris (“Euronext Paris”) on November 14, 2014 of
€6.34, the theoretical value per right amounts to €0.37 and the theoretical ex
-right price (TERP) amounts to €5.97.

The subscription price of €4.50 per share represents a 29.02% discount compared
to the closing price of ONXEO on November 14, 2014 and a 24.65% discount
compared to the TERP.

Reducible subscriptions will be permitted at a price of €4.50 per new share on
top of irreducible subscriptions.

The rights issue will be open to the public in France and Denmark only.

Subscription commitments

Financière de la Montagne (which holds c.8.92% of the share capital and voting
rights of the Company) has irrevocably committed to (i) exercise on an
irreducible basis all its 2,807,570 rights and (ii) place a subscription order
in cash for a total amount of €13.5 million. Payment of the subscription price
of the new shares subscribed on an irreducible and reducible basis will be made
by offsetting receivables in accordance with the provisions of Article 1289 of
the Civil Code and subsequent, with the terms of the current account advance
agreement signed with the Company on July 18, 2014. Financière de la Montagne
reserves flexibility to acquire preferential rights on the market and to
subscribe new shares on an irreducible and/or reducible basis for an amount
greater than its subscription commitment.

Nyenburgh and Capital Ventures International have irrevocably committed to
subscribe on an irreducible basis and reducible basis for respective global cash
amounts of €5 million and €20 million.

Nyenburgh reserves the flexibility to acquire preferential rights on the market,
it being indicated that the amount of its investment will not exceed that of its
subscription commitment, i.e. €5 million.

The transaction is therefore fully secured through the subscription commitments
described above, upon exercise of all financial instruments giving access to
shares in the Company before November 26, 2014.

Indicative timetable

The subscription period will be opened from November 24, 2014 until December 3,
2014. Rights will be detached and traded on Euronext Paris from November 24,
2014 until December 3, 2014 and on Nasdaq OMX Copenhagen from November 24, 2014
until December 1, 2014 under ISIN code FR0012314656. A Company press release
announcing the results of the capital increase and, if applicable the full or
partial exercise of the extension clause, will be published by the Company on
December 12, 2014.

The settlement, delivery and trading of the new shares is expected to take place
on December 16, 2014. The new shares will be fully fungible with the Company's
existing shares and will trade on the same quotation line under the same ISIN
code FR0010095596.

Participants

Natixis and Oddo & Cie are acting as Joint Coordinators and Joint Bookrunners on
this transaction.

Société Générale Securities Services will be responsible for establishing the
funds deposit certificate.

Nordea Bank Danmark A/S will be the subscription agent for the rights issue in
Denmark.

Information available to Danish shareholders

For any shareholders holding shares in the Company through the book-entry
facilities of VP Securities A/S on November 21 2014 (“VP Beneficiaries”) and any
investors acquiring preferential subscription rights on NASDAQ OMX (“PSR
Investors” and VP Beneficiaries and PSR Investors collectively referred to as
“Danish Investors”) the following applies. Danish Investors can contact Nordea
Bank Danmark A/S for further information in respect to the Danish offering:

Subscription Rights

The subscription rights allocated to VP Beneficiaries and/or acquired by PSR
Investors cannot be transferred between Euroclear Bank SA/NV & Clearstream
Banking (Luxembourg LLC) and VP Securities A/S during the subscription period
(identical for both markets, i.e. 24 November to 3 December 2014).

The preferential subscription rights will be admitted to trading on NASDAQ OMX
under ISIN FR0012314656 during the period November 24, 2014-December 1, 2014.

Subscription of new shares on the basis of preferential subscription rights

Danish Investors wishing to subscribe for new shares on the basis of
preferential subscription rights must pay for the new shares in accordance with
the rules and procedures of the shareholder’s own account holding institution or
financial intermediary no later than on December 3, 2014. Any new shares
subscribed by Danish Investor’s exercise of preferential subscription rights
will be registered as temporary certificates in the investor’s account with VP
Securities A/S in a temporary ISIN FR0012327773, which will not be admitted to
trading and official listing on NASDAQ OMX. These temporary certificates shall
not be transferred between (i) Euroclear Bank SA/NV & Clearstream Banking
(Luxembourg LLC) and (ii) VP Securities A/S on the other hand. Such certificates
will be converted into new shares upon completion of the offering as issuance of
the new shares.

Subscription of new shares on the basis of reducible orders

Danish Investors having subscribed for new shares on the basis of exercise of
preferential subscription rights may also request to subscribe for additional
new shares by submitting a reducible order. In order for such shareholders and
investors to place a reducible order to subscribe for additional new shares, a
subscription form must be completed, signed and submitted to the shareholder or
investor’s own custodian bank or financial intermediary in due time allowing for
such custodian bank or financial intermediary to submit the order to Nordea Bank
Danmark A/S before expiry of the subscription period December 3, 2014. The
subscription form may be found and downloaded from the Company’s website
(www.onxeo.com (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2F
w 
ww.onxeo.com&esheet=50985939&newsitemid=0&lan=en
-US&anchor=www.onxeo.com&index=1&md5=f6f4180b410a93a91b89d92bd227ce3c)). The
subscription form must be received by Nordea Bank Danmark A/S, Corporate Actions
no later than at 17.00 on December 3, 2014 and hence must be submitted to the
investor’s own financial intermediary well ahead of such date. Only one
subscription form per Danish Investor is allowed.

The allocation of any new shares based on reducible orders will be made
automatically based on a ratio published by Euronext Paris around December 12,
2014. Reducible orders will be met based on demand and in proportion to the
number of new shares subscribed on a non-reducible basis (i.e on the basis of
exercised preferential subscription rights).

Any new shares subscribed and allocated on the basis of reducible orders will be
registered against payment as temporary certificates in the investor’s account
with VP Securities A/S in the temporary ISIN FR0012327773, which will not be
admitted to trading and official listing on NASDAQ OMX. These temporary
certificates shall not be transferred between (i) Euroclear Bank SA/NV &
Clearstream Banking (Luxembourg LLC) and (ii) VP Securities A/S on the other
hand. Such certificates will be converted into new shares upon completion of the
offering as issuance of the new shares.

Payment for additional shares shall be made no later than 15 December 2014 based
on the indicative timetable against registration of the temporary certificates
on the investor’s account with VP Securities A/S.

Subscription price

For Danish Investors the subscription price payable for the new shares will be
the DKK amount equal to €4.50, converted at a euro/Danish kroner exchange rate
in effect as of 17 November, 2014 (ie. DKK33.50).

Nordea Bank Danmark A/S contact detail

Nordea Bank Danmark A/S, Corporate Actions, corpact@nordea.com, +45 3333 5092

Information available to the public

The Prospectus filed with the Autorité des marchés financiers (the “AMF”) under
visa number 14-600 dated November 17, 2014, consists of (i) ONXEO’s Document de
Référence filed with the AMF on April 7, 2014 under number D.14-0303, (ii)
ONXEO’’s Actualisation du Document de Référence filed on November 17, 2014 under
number D.14-0303-A01, (iii) the Document E (including the summary of Document E)
filed with the AMF on May 26, 2014 under number E.14-0034, (iv) a securities
note and (v) a summary of the Prospectus (included in the securities note).

Copies of the Prospectus may be obtained free of charge at ONXEO’’s registered
office, 49, boulevard du Général Martial Valin – 75015 Paris – France, on the
Company’s corporate website
(www.onxeo.com (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2F
w 
ww.onxeo.com&esheet=50985939&newsitemid=0&lan=en
-US&anchor=www.onxeo.com&index=2&md5=49e67eb59b7f18a03143a7efc506fa30)), on the
AMF’s website (www.amf
-france.org (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww
. 
amf-france.org&esheet=50985939&newsitemid=0&lan=en-US&anchor=www.amf
-france.org&index=3&md5=53ae50d9d2d179769d237c80d3d84a3f)) and from the Joint
Coordinators and Bookrunners.

A translation of the summary of the prospectus into Danish together with a non
-binding translation into English of all the other documents constituting the
prospectus have been prepared by the Company regarding the Danish offer. In case
of discrepancies between the French prospectus and the English translation, the
French version prevails. Such documents can also be obtained free of charge at
Onxeo’s registered office, 49, boulevard du Général Martial Valin – 75015 Paris
– France and on the Company’s corporate website
(www.onxeo.com (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2F
w 
ww.onxeo.com&esheet=50985939&newsitemid=0&lan=en
-US&anchor=www.onxeo.com&index=4&md5=b2904c8e6acbac64e2c94bf066beacc2)).

The Company draws investors’ attention to the risk factors described in chapter
5.2.1 of the Document de Référence, in chapter 4.2 of Document E and chapter 2
of the Securities Note before taking any investment decision.

The occurrence of such risks (in whole or in part) can have a material adverse
change in the Company’s business or financial situation, the Group’s results or
its capacity to achieve its objectives.

About ONXEO

ONXEO has the vision to become a global leader and pioneer in oncology, with a
focus on orphan or rare cancers, through developing innovative therapeutic
alternatives to “make the difference”. The ONXEO teams are determined to develop
innovative medicines to provide patients with hope and significantly improve
their lives.

Key products at advanced development stage are:

Livatag®(Doxorubicin Transdrug™): Phase III in hepatocellular carcinoma

Validive® (Clonidine Lauriad®): Phase II in severe oral mucositis: Positive
preliminary top-line results

Beleodaq® (belinostat): Registered and available in the USA for peripheral T
-cell lymphoma

Disclaimer

The offer is open to the public in France and Denmark following the delivery of
the visa on the Prospectus by the French Autorité des marchés financiers (the
« AMF ») and the AMF’s notification of the Danish Financial Services Authority
(the « FSA »).

Copies of the prospectus registered with the AMF on November 17, 2014 under
number 14-600, comprised of the registration document filed with the AMF April
7, 2014 under number D.14-0303, of the registration document update filed with
the AMF on November 17 2014 under number D.14-0303-A01, of the merger document
(including a summary) registered by the AMF on May 26, 2014 under number E.14
-0034 and of a securities note (including a summary of the prospectus), are
available without charge from ONXEO (49 boulevard du Général Martial Valin,
75015 Paris – France), as well as on the websites of ONXEO
(www.onxeo.com/fr/ (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2
F 
%2Fwww.onxeo.com%2Ffr%2F&esheet=50985939&newsitemid=0&lan=en
-US&anchor=www.onxeo.com%2Ffr%2F&index=5&md5=f9912d493b88f1d223736252027ed520))
and from the AMF (www.amf
-france.org (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww
. 
amf-france.org&esheet=50985939&newsitemid=0&lan=en-US&anchor=www.amf
-france.org&index=6&md5=d1c88fd63557aa9f9db0e65d49a48ae9)). A translation into
English of the prospectus as well as a translation into Danish of the summary of
the prospectus are available without charge at the registered office of ONXEO
(49 boulevard du Général Martial Valin, 75015 Paris – France) and on its website
(www.onxeo.com/fr/ (http://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2
F 
%2Fwww.onxeo.com%2Ffr%2F&esheet=50985939&newsitemid=0&lan=en
-US&anchor=www.onxeo.com%2Ffr%2F&index=7&md5=4d8d097f9f33ca8ee8d11e74f6d76d4e)).
ONXEO draws the public’s attention to the risks contained in pages 84 to 90 of
its reference document, in pages 95 to 99 of its merger document and in Chapter
2 of the securities note.

With respect to Member States of the European Economic Area that have transposed
European Directive 2003/71/EC of the European Parliament and European Council of
4 November, 2003 (as amended in particular by Directive 2010/73/EU to the extent
that the said Directive has been transposed into each Member State of the
European Economic Area) (the “Prospectus Directive”), no action has been taken
or will be taken to permit a public offering of the securities referred to in
this press release requiring the publication of a prospectus in any Member State
other than France and Denmark . Therefore, such securities may not be and shall
not be offered in any Member State (other than in France and Denmark) except in
accordance with the exemptions of Article 3(2) of the Prospective Directive to
the extent they have been transposed by the relevant Member State or, otherwise,
in cases not requiring the publication of a prospectus by ONXEO under Article
3(2) of the Prospective Directive and/or the applicable regulations in such
Member State.

This press release and the information it contains are being distributed to and
are only intended for persons who are (i) outside the United Kingdom, (ii)
investment professionals falling within Article 19(5) of the Financial Services
and Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”), (iii) high
net worth entities and other such persons falling within Article 49(2)(a) to (d)
of the Order (“high net worth companies”, “unincorporated associations”, etc.)
or (iv) other persons to whom an invitation or inducement to engage in
investment activity (within the meaning of Section 21 of the Financial Services
and Market Act 2000) may otherwise lawfully be communicated or caused to be
communicated (all such persons in (i), (ii), (iii) and (iv) together being
referred to as “Relevant Persons”). Any invitation, offer or agreement to
subscribe, purchase or otherwise acquire securities to which this document
relates will only be engaged with Relevant Persons. Any person who is not a
Relevant Person should not act or rely on this press release or any of its
contents.

This press release and the information it contains do not, and will not,
constitute an offer to subscribe for or sell, nor the solicitation of an offer
to subscribe for or buy, securities of ONXEO in the United States of America or
any other jurisdiction where restrictions may apply. Securities may not be
offered or sold in the United States of America absent registration or an
exemption from registration under the U.S. Securities Act of 1933, as amended
(the “U.S. Securities Act”), it being specified that the securities of ONXEO
have not been and will not be registered within the US Securities Act. ONXEO
does not intend to register securities or conduct a public offering in the
United States of America.

The distribution of this press release may be subject to legal or regulatory
restrictions in certain jurisdictions. Any person who comes into possession of
this press release must inform him or herself of and comply with any such
restrictions.

Any decision to subscribe for or purchase the shares or other securities of
ONXEO must be made solely based on information publicly available about ONXEO.
Such information is not the responsibility of Natixis and Oddo & Cie and has not
been independently verified by Natixis and Oddo & Cie.

SUMMARY OF THE PROSPECTUS

AMF approval No. 14-600 dated November 17, 2014

The summary consists of a set of key disclosures, referred to as "Elements",
presented in five sections, A to E, and numbered from A.1 to E.7.

This summary contains all the Elements that are required in the prospectus
summary concerning this class of securities and this type of issuer. Since not
all Elements have to be filled in, the numbering in this summary is not
continuous.

It is possible that relevant information may not be provided about a given
Element that should be included in this summary, given the class of securities
and the type of issuer involved. In that event, a brief description of the
Element in question is included in the summary, with the notation "not
applicable".


A.1        Notice to readers                           This summary
                                                       should be read
                                                       as an
                                                       introduction to
                                                       the
                                                       Prospectus.Any
                                                       decision to
                                                       invest in the
                                                       securities
                                                       issued in
                                                       connection with
                                                       this public
                                                       offering or for
                                                       which an
                                                       application is
                                                       made for
                                                       admission to
                                                       trading on a
                                                       regulated market
                                                       should be based
                                                       on a thorough
                                                       review of the
                                                       Prospectus by
                                                       the investor.If
                                                       a claim relating
                                                       to information
                                                       contained in
                                                       this Prospectus
                                                       is brought
                                                       before a court,
                                                       the plaintiff
                                                       investor may be
                                                       required to bear
                                                       the costs of
                                                       translating the
                                                       Prospectus prior
                                                       to the
                                                       commencement of
                                                       judicial
                                                       proceedings,
                                                       pursuant to the
                                                       national
                                                       legislation of
                                                       the Member
                                                       States of the
                                                       European Union
                                                       or of the States
                                                       Parties to the
                                                       agreement on the
                                                       European
                                                       Economic
                                                       Area.Those who
                                                       prepared this
                                                       summary
                                                       including, as
                                                       applicable, its
                                                       translation, may
                                                       only be subject
                                                       to civil
                                                       liability if the
                                                       contents of the
                                                       summary are
                                                       misleading,
                                                       inaccurate or
                                                       contradict other
                                                       parts of the
                                                       Prospectus or
                                                       if, when read
                                                       together with
                                                       the other parts
                                                       of the
                                                       Prospectus, they
                                                       do not contain
                                                       the critical
                                                       information that
                                                       would help
                                                       investors who
                                                       are considering
                                                       investing in
                                                       these
                                                       securities.
A.2        Consent of the Issuer concerning the        Not applicable.
           use of the Prospectus
                                Section
                              B – Issuer
B.1        Legal and commercial name                   ONXEO (the
                                                       “Company” and,
                                                       together with
                                                       all its
                                                       consolidated
                                                       subsidiaries,
                                                       the “Group”).
B.2        Registered Office / Legal form /
           Governing law / Country of                    · Registered
           incorporation                               office: 49
                                                       boulevard du
                                                       Général Martial
                                                       Valin, 75015
                                                       Paris – France.
                                                         · Legal form:
                                                       Limited
                                                       liability
                                                       company with a
                                                       Board of
                                                       Directors.
                                                         · Governing
                                                       law: French law.
                                                         · Country of
                                                       incorporation:
                                                       France.


B.3     Description of the Issuer's      Founded in 1997, listed on the
        operations and main business     regulated market Euronext in Paris
        lines                            (“Euronext Paris”) in 2005 and
                                         also listed on NASDAQ OMX in
                                         Denmark (“NASDAQ OMX”) since
                                         August 1st, 2014, the Company is a
                                         European biopharmaceutical company
                                         specialised in the field of orphan
                                         oncology products and has the
                                         ambition of becoming a leading
                                         player in this field, by linking
                                         innovation to patient needs.
                                         The Company researches and
                                         develops innovative drugs, up to
                                         the point of their marketing, for
                                         the treatment of cancer and its
                                         related pathologies, specifically
                                         for severe or rare orphan
                                         diseases. Its product portfolio in
                                         this area has several programs in
                                         advanced stages of clinical
                                         development, with each one
                                         positioned for an indication where
                                         there is a severe medical need and
                                         very significant sales potential:

PRODUCT                 PH1        PH2        PH3        REGISTRATION
MARKET         MILESTONES
Belinostat(PTCL
---             US
2nd line)
---        Registration
                                                                               
- 
--          07/2014
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--
                                                                               
- 
--


Combo                              ---
BelCHOP(PTCL 1st                   ---
line)                              ---
                                   ---
                                    --


Livatag®(CHC 2nd                              ---
line)                                         ---
                                              ---
                                              ---
                                              ---
                                              ---
                                              ---
                                              ---
                                              ---
                                              ---
                                                -


Validive®(Severe                      ---
Phase II
oral                                  ---
finalized
mucositis in                          ---
head and neck                         ---
cancers)                              ---
                                      ---
                                       --


Research sponsor              ---
         Solid
NCI                           ---
tumours
                                -
& lymphoma

in

patients

with

hepatic

dysfunction


  · Livatag® - a nanoparticle formulation of doxorubicin, currently in Phase III
for the treatment of hepatocellular carcinoma (primary liver cancer). The
clinical trial is in progress in 8 European countries (including France) as well
as in the United States and almost 35% of the foreseen patients have been
“randomised” on the date of the Prospectus. The drug has the status of orphan
drug in Europe and in the United States, and the “Fast track” status in the
United States, allowing to optimize discussions and the duration of development
in general.
  · Validive® - a mucoadhesive tablet (Lauriad® technology) charged with an
active agent (clonidine) developed to prevent and treat severe oral mucositis in
patients having gone through chemoradiotherapy for head and neck cancer. At end
-October 2014, the Company announced positive preliminary results for the
international phase II trial, comparing the effectiveness and tolerance of
Validive® versus a placebo for preventing severe oral mucositis in patients
affected by an ENT cancer. The committee of experts for the trial confirmed that
these results support the continuation of a development plan for Validive®. On
the basis of the positive phase II results, the company will prepare a phase III
trial in order to evaluate the effectiveness of Validive®. The medicine received
a “Fast Track” designation by the US Food & Drug Administration (“FDA”). In
parallel, the drug obtained a “Orphan Drug” status in Europe, from the European
Medicines Agency. These designations will facilitate discussions and the
duration of development in general. The Company expects to submit this new study
during 2015. The potential sales of the product are evaluated at between EUR 200
-400 million.
  · Belinostat (Beleodaq®), a histone deacetylase inhibitor (HDAC) in Phase II
for which several indications were tested. Beleodaq® received from the FDA
conditional marketing approval for the US for Beleodaq® for a first indication
of treatment of peripheral T-cell lymphoma (“PTCL”). Under a partnership
agreement between Topotarget and Spectrum Pharmaceuticals Inc., Beleodaq® has
been marketed in the United States by the latter since the summer of 2014 for
this indication. According to Spectrum Pharmaceuticals, sales of Beleodaq®
during the third quarter of 2014 generated net revenues of US$2 million. The
Company is discussing other relevant indications to be tested with Spectrum.

The Company also successfully led the development of two mucoadhesive tablet,
Loramyc® / Oravig®, of miconazolefor the treatment of oropharyngeal candidiasis,
and Sitavig®, a mucoadhesive tablet of acyclovir for the treatment of recurrent
herpes, through to their approval in Europe and the United States. These
products are covered by licensing agreements with business partners which
generate revenue for the Company through milestone and royalty payments on the
sales, but do not form the object of development and do not represent strategic
assets for the company.


B.4a        Significant recent trends           Merger with Topotarget -
            affecting the issuer and its        New corporate nameThe
            business lines                      General Shareholders’
                                                Meeting on June 30,
                                                2014, approved, in
                                                particular, the
                                                principle of a merger by
                                                absorption of Topotarget
                                                and decided to change
                                                the name of the Company,
                                                originally BioAlliance
                                                Pharma, to Onxeo.
                                                Topotarget's
                                                Extraordinary General
                                                Shareholder’s Meeting,
                                                held on June 27, 2014
                                                approved the merger
                                                agreement and determined
                                                that Topotarget should
                                                be dissolved after the
                                                completion of the
                                                merger.The merger was
                                                carried out on July 22,
                                                2014. On the basis of an
                                                exchange ratio of 2 new
                                                Onxeo shares for 27
                                                existing Topotarget
                                                shares, Topotarget was
                                                valued at EUR 83.4
                                                million on June 30,
                                                2014, the date of change
                                                of control.The Company's
                                                shares are listed on
                                                Euronext Paris and,
                                                since August 1, 2014, on
                                                NASDAQ OMX.A description
                                                of the merger is
                                                included in document E
                                                filed with the French
                                                Financial market
                                                authority (Autorité des
                                                marchés financiers – the
                                                “AMF”) on May 26, 2014
                                                under registration
                                                number E. 14
                                                -0034.Activity during
                                                the first half of
                                                2014The first half of
                                                2014 was characterised
                                                by significant
                                                development in the
                                                flagship programs
                                                Livatag® and Validive®,
                                                (respectively continuing
                                                Phase II and III and
                                                obtaining "Fast Track"
                                                status from the FDA for
                                                both drugs.The Company
                                                also received
                                                conditional American
                                                market approval for
                                                Beleodaq® for second
                                                -line treatment of
                                                patients with PTCL.
                                                Because of this and in
                                                accordance with the
                                                license agreement
                                                concluded between
                                                Topotarget and Spectrum
                                                Pharmaceuticals, Inc. to
                                                develop and market the
                                                product in North
                                                America, Beleodaq® is
                                                available to patients
                                                since early August 2014,
                                                and is being marketed in
                                                the United States by
                                                that partner. Around
                                                US$2 million of sales
                                                have been recorded since
                                                its launch during the
                                                third quarter of 2014.In
                                                addition, the Company
                                                signed a partnership
                                                agreement with Innocutis
                                                Holdings, to market
                                                Sitavig® in the United
                                                States. The product's
                                                actual launch in the
                                                territory took place in
                                                August 2014.

Revenue for the third quarter
of 2014On November 6, 2014, the
Company published its
consolidated revenues on
September 30, 2014.Consolidated
revenues for the 3rd quarter of
2014 increased significantly
compared to the same period in
2013:

Consolidated accounts – IFRS             Q3          Q3 2013
Standards – in thousands of             2014
Euros
Non-recurrent revenues deriving        19,911            133
from licensing agreements
Recurrent revenues deriving               622            113
from licensing agreements
Other revenues                             55              0
Total                                  20,588            246


- Non-recurrent revenues deriving from licensing agreements grew considerably by
virtue of the recording (i) of the milestone of US$25 million paid by Spectrum
Pharmaceuticals as consideration for the marketing authorisation of Beleodaq®,
and (ii) of the amount of US$1.9 million owed by Innocutis as consideration of
the delivery of the first commercial batch of Sitavig®.

- Recurrent revenues consisted of royalties, and notably those on the sales of
Beleodaq® and of Sitavig® in the US market.

Consequently to the merger and by virtue of the EUR 10 million loan by the
principal shareholder, Financière de la Montagne, implemented in July, the
Company’s cash position was greatly strengthened, reaching EUR 20.7 million on
September 30, 2014.

During the 4th quarter of 2014, this cash position shall be strengthened by the
payment of the milestone of US$25 million by Spectrum Pharmaceuticals (see
below), and by the second instalment of the financing by BPIfrance, dedicated to
the development of Livatag®, within the context of the NICE (Nano Innovation for
Cancer) consortium.

Governance

Once the merger had been realised, Mr. Bo Jesper Hansen and Mr. Per Samuelsson
decided to resign from the Board of Directors on November 7, 2014.

In parallel, the Board of Directors of the Company should evolve in the near
future to reinforce its expertise, notably scientific, with supplementary
capacities, in order to support its ambition of becoming a global leader in the
field of orphan drugs in oncology.

Payment of US$25 million by Spectrum Pharmaceuticals by way of the registration
of Beleodaq®

The Company announced on November 13, 2014 the receipt of a US$25 million
milestone payment, due from Spectrum Pharmaceuticals, as consideration for the
registration of Beleodaq® on July 3, 2014.


B.5                     Description           As of the Prospectus date, the
                of the Groupand the           Company is the controlling
           issuer's placewithin the           parent company of a group with
                              Group           the following structure:

                                                           Onxeo S.A.

 Laboratoires              SpeBio                    BioAlliance
TopotargetSwitzerland        Topotarget        Topotarget
  BioAlliance        (Netherlands                         Pharma
(Switzerland–            UK             Germany
Pharma(France              – 50%)        Switzerland(Switzerland
100%)         (United           (Germany
      – 100%)                                            – 100%)
Kingdom-           –100%)

100%)



B.6        Principalshareholders        On October 31, 2014 and based on
                                        information brought to the Company's
                                        attention, the shareholding structure
                                        of the Company was as follows:

Shareholders                          Before
After
                                     dilution
dilution (1)
                 Number                    % of                Number
      % of
                   of                    capital                 of
capital
                 shares                    and                 shares
and
                                          voting
voting
                                        rights (2)
rights (2)
 Financière               2,807,570                  8.92%
2,807,570                  8.20%
   de la
  Montagne
 HealthCap                  924,632                  2.94%
924,632                  2.70%
   Funds
   Other                 27,758,442                 88.15%
30,494,964                 89.10%
shareholders
   Total                 31,490,644                  100 %
34,227,166                   100%

(1)           Taking into account the 165,419 warrants, vested or unvested,
              issued by the Company's Board on September 21, 2011, September
              13, 2012, September 19, 2013 and September 22, 2014, the stock
              options, vested or unvested, allocated by the Board on August
              25, 2010, December 16, 2010, September 21, 2011, January 26,
              2012, September 13, 2012, September 19, 2013 and September 22,
              2014 entitling subscription for 1,157,603 shares, the 148,500
              free shares allocated by the Company's Board on September 22,
              2014, as well as the share issuance rights granted in connection
              with the equity line agreement (PACEO) between the Company and
              Société Générale on January 25, 2013 giving the right to
              subscribe for a maximum amount of 1,265,000 shares.
(2)           All shares have the same voting rights.

As of the date of the Prospectus, no shareholder holds a controlling interest
the Company.

To the knowledge of the Company, there is no concerted action among
shareholders.


B.7        Key selected          Consolidated Financial
           historical            InformationConsolidated financial
           financial data        statementsThe following tables are taken
                                 from the BioAlliance Pharma Group's
                                 audited consolidated balance sheet and
                                 income statement for the fiscal years
                                 ended December 31, 2013, 2012 and 2011,
                                 prepared in accordance with IFRS
                                 (International Financial Reporting
                                 Standards) as adopted by the European
                                 Union (unless otherwise
                                 indicated).Readers should refer to the
                                 notes to the Group's consolidated
                                 financial statements.

[TABLE OMITTED]

Half-year consolidated financial information

The tables below are taken from the Group's consolidated balance sheet and
profit and loss statement, which received a limited review by the Company's
statutory auditors for the six months ending June 30, 2014 and June 30, 2013.
This half-year consolidated financial information was prepared in accordance
with International Financial Reporting Standards Repository (IFRS), as adopted
by the European Union (unless otherwise noted).

For the purposes of the June 30, 2014 half-year financial statements, in
accordance with international accounting standards, BioAlliance is considered to
have taken over Topotarget as of the date of the General Shareholder’s Meeting
that passed on the merger, i.e. June 30, 2014, no suspensive condition, other
than of an administrative nature, applying after that date. The 2014 first half
results are only those BioAlliance Pharma. Topotarget and its subsidiaries are
included in the numbers as of June 30, 2014 and only affect the balance sheet. A
pro forma income statement can be found in Note B8 below.

Readers should refer to the notes to the Group's consolidated financial
statements.

[TABLE OMITTED]


B.8        Key selected pro forma        Annual pro forma financial
           financial information         informationSince the Company has not
                                         yet concluded and published post
                                         -merger annual financial statements,
                                         the pro-forma annual financial
                                         information presented below,
                                         extracted from Document E, is purely
                                         illustrative and reflects the merger
                                         between BioAlliance Pharma and
                                         Topotarget, as if it had taken place
                                         on January 1, 2013. The tables below
                                         do not give an indication of the
                                         results or of the financial situation
                                         of the combined company which would
                                         have been achieved for the period
                                         ended December 31, 2013 if the merger
                                         had taken place on January 1, 2013.
                                         In the same way, they do not give an
                                         indication of future results or of
                                         the financial situation of the
                                         combined entity.

  · Unaudited pro forma balance sheet on December 31, 2013

[TABLE OMITTED]

  · Unaudited pro forma profit and loss statement on December 31, 2013

[TABLE OMITTED]

Half-year pro forma financial information

This pro forma financial information is presented pursuant to Instruction No.
2005-11 of December 13, 2005, Annex II of the AMF. These pro forma financial
information have been prepared in accordance with Annex II "pro forma financial
information building block" of EC Regulation No. 809/2004 of the European
Commission and pursuant to the recommendations issued by the Committee of
European Securities Regulators in February 2005 on the preparation of pro forma
financial information required by Regulation No. 809/2004 on the prospectus.

The half-yearly pro forma financial information presented reflects BioAlliance
Group's takeover of Topotarget as of June 30, 2014.

The reader's attention is drawn to Note 4.2 to the Group's half-year
consolidated financial statements of June 30, 2014 included in the Annex to the
Reference Document Update.

[TABLE OMITTED]

B.9         Earnings forecast or        Not applicable.
            estimate
B.10        Reservations on             Not applicable.
            historical financial
            information
B.11        Net working capital         The Company certifies that, in its
                                        opinion, the Group’s net
                                        consolidated working capital,
                                        prior to the net proceeds of the
                                        share capital increase described
                                        in this Securities Note, is
                                        sufficient to meet its obligations
                                        during the twelve months following
                                        the authorisation date of this
                                        Prospectus.

C.1        Type, class and                 Common shares of the same class
           identification number of        as the Company's existing
           the new shares                  shares, to be issued at the unit
                                           price of EUR 4.50, including the
                                           issue premium. Holders of the
                                           new shares will be entitled to
                                           receive dividends and all other
                                           distributions the Company may
                                           decide as of the date of their
                                           issuance. Once issued, the New
                                           Shares will be traded on the
                                           same listing line as the
                                           existing shares.- ISIN Code:
                                           FR0010095596.- Listing symbol:
                                           ONXEO- ICB sector
                                           classification: 4577 –
                                           Pharmaceuticals- Place of
                                           listing:
                                             · Euronext Paris
                                             · NASDAQ OMX
C.2        Issue currency                  The new shares shall be
                                           subscribed in Euros.


C.3        Number of shares issued        As of the Prospectus date, the
           / Nominal value per            Company's capital consisted of
           share                          [31,490,644] fully paid up shares
                                          having a nominal value of EUR 0.25
                                          each.The new issue will consist of
                                          7,872,661 shares with a par value
                                          of EUR 0.25, fully paid upon
                                          subscription, likely to be extended
                                          to 9,053,560 shares in the event of
                                          full exercise of the Extension
                                          Clause (as defined below) and to a
                                          maximum number of 9,246,098 shares
                                          upon exercise of all financial
                                          instruments giving access to the
                                          Company’s share capital before
                                          November 26, 2014 and the full
                                          exercise of the Extension Clause
                                          (the “New Shares”).Depending on the
                                          size of the demand, the Board of
                                          Directors may decide to increase by
                                          15% the amount of initial shares to
                                          be issued, i.e. up to a maximum
                                          amount of 1,180,899 shares, due to
                                          the exercise of the extension
                                          clause (the “Extension Clause”).
                                          The implementation of the Extension
                                          Clause is exclusively intended to
                                          fill reducible orders in excess.
                                          Based on the subscription
                                          commitments (see section E.3), the
                                          Extension Clause will be exercised
                                          for at least 682,894 shares,
                                          increasing the offering size to a
                                          total amount of at least EUR
                                          38,499,997.50 (excluding the
                                          exercise of dilutive instruments
                                          prior to November 26, 2014).

C.4        Rights             Under current French law and in accordance
           attached to        with the Company's by-laws, the main rights
           the shares         attached to the New Shares are as follows:-
                              dividend rights;- voting rights;-
                              preferential subscription rights to subscribe
                              for shares of the same class;- right to share
                              in any surplus in the event of liquidation;-
                              double voting rights allocated to all fully
                              paid-up shares registered in the name of the
                              same shareholder for at least two years.

C.5        Restrictions on the        Not applicable.
           sale of the shares
C.6        Application for            It is expected that the New Shares will
           admission                  trade on the Euronext Paris and on
                                      NASDAQ OMX as of December 16, 2014, on
                                      the same line as the existing shares
                                      (ISIN code FR0010095596).
C.7        Dividend policy            The Company has not paid any dividends
                                      to its shareholders. The Company does
                                      not foresee any dividend payments in the
                                      upcoming years.

D.1        Principalrisks         Before making an investment decision,
           specific to the        prospective investors are asked to consider
           issuer                 the following risk factors:
           and its                  · liquidity risk and lack of financial
           business               resources in the medium term, the
           sector                 continuation of research requiring obtaining
                                  new financing on a regular basis;
                                    · risks related to research and
                                  development of drugs;
                                    · risk of serious side effects during a
                                  clinical trial or negative results of a
                                  clinical trial that may affect Company
                                  growth;
                                    · risk of significant delays carrying out
                                  clinical trials that may affect Company
                                  growth;
                                    · risks associated with outsourcing
                                  Company’s R&D and production;
                                    · risks related to pricing policies and
                                  drug reimbursements;
                                    · risk of delays in obtaining pricing and
                                  reimbursement rates or at lower than
                                  expected levels;
                                    · risk of a marketed product being
                                  delisted;
                                    · risks associated with commercial
                                  partnership agreements;
                                    · risks related to the safety of products
                                  sold;
                                    · challenges and constraints related to
                                  the regulatory environment;
                                    · limits to patent protection and other
                                  intellectual property rights;
                                    · risk of patents falling into the public
                                  domain at the end of the license or the
                                  eventual emergence of generic products being
                                  commercialised;
                                    · risks related to the integration of
                                  Topotarget into the Company, the costs
                                  related to this integration and to achieving
                                  synergies within the merged group; and
                                    · risks associated with the need to retain
                                  key executives and personnel after the
                                  merger.


D.3        Principal risks            The principal risk factors specific to
           specific to the new        the Company's New Shares are listed
           shares                     below:
                                        · the market for the preferential
                                      subscription rights may only offer
                                      limited liquidity and may be subject
                                      to high volatility;
                                        · shareholders not exercising their
                                      preferential subscription rights may
                                      see their ownership stake in the
                                      Company’s share capital diluted;
                                        · if the Extension Clause is
                                      exercised, any shareholder who has not
                                      given their financial intermediary a
                                      reducible order could be partially
                                      diluted;
                                        · the market price for the Company's
                                      shares may fluctuate and fall below
                                      the subscription price for shares
                                      issued upon exercise of the
                                      preferential subscription rights;
                                        · the volatility and liquidity of
                                      the Company’s shares may fluctuate
                                      significantly;
                                        · sell orders for the Company's
                                      shares or preferential subscription
                                      rights may occur on the market during
                                      the subscription period in the case of
                                      preferential subscription rights, or
                                      during or after the subscription
                                      period in the case of shares, and may
                                      have a negative impact on the market
                                      price of the shares or of the
                                      preferential subscription rights;
                                        · in the event the market price of
                                      the Company’s shares falls, the value
                                      of the preferential subscription
                                      rights could sustain a loss in value;
                                        · the issue is not part of an
                                      underwriting agreement;
                                        · shareholder rights in a French
                                      company may differ from shareholder
                                      rights of companies in other
                                      countries;
                                        · shareholder rights are governed by
                                      the Company by-laws and French law;
                                      and
                                        · shareholders subscribing to the
                                      New Shares in Danish kroner are
                                      exposed to the risk of appreciation of
                                      the Danish kroner against the euro
                                      during the subscription period.

                                 Section E – Offering
E.1        Total proceeds of the offering and
           estimate of the total cost of the           · Gross proceeds of
           issue                                     the capital increase:
                                                     EUR 35,426,974.50,
                                                     which may be increased
                                                     to EUR 40,741,020 in
                                                     case of full exercise
                                                     of the Extension
                                                     Clause, to a maximum
                                                     amount of
                                                     approximately EUR
                                                     41,607,441 upon
                                                     exercise of all
                                                     financial instruments
                                                     giving access to the
                                                     Company’s share
                                                     capital and the full
                                                     exercise of the
                                                     Extension Clause and
                                                     approximately EUR
                                                     26,570,227.50 in the
                                                     event that the issue
                                                     is limited to 75% of
                                                     the planned capital
                                                     increase.

                                                       · Estimated costs of
                                                     the capital increase
                                                     (remuneration of
                                                     financial
                                                     intermediaries and
                                                     legal and
                                                     administrative costs,
                                                     subscription
                                                     commissions,
                                                     remuneration due by
                                                     way of the currency
                                                     hedging contract
                                                     concluded with Nordea
                                                     Bank Finland Plc):
                                                     approximately EUR
                                                     2,879,048.98, which
                                                     may be increased to
                                                     approximately EUR
                                                     3,081,514.11 in case
                                                     of full exercise of
                                                     the Extension Clause
                                                     and a maximum amount
                                                     of approximately EUR
                                                     3,114,524.75 upon full
                                                     exercise of all
                                                     financial instruments
                                                     giving access to the
                                                     Company’s share
                                                     capital and the full
                                                     exercise of the
                                                     Extension Clause.

                                                       · Estimated net
                                                     proceeds of the
                                                     capital increase:
                                                     approximately EUR
                                                     32,547,925.52, which
                                                     may be increased to
                                                     approximately EUR
                                                     37,659,505.89 in case
                                                     of full exercise of
                                                     the Extension Clause,
                                                     to a maximum amount of
                                                     approximately EUR
                                                     38,492,916.25 upon
                                                     exercise of all
                                                     financial instruments
                                                     giving access to the
                                                     Company’s share
                                                     capital and the full
                                                     exercise of the
                                                     Extension Clause and
                                                     to approximately EUR
                                                     24,028,620.58 in case
                                                     the issue is limited
                                                     to 75% of the planned
                                                     capital increase.


E.2a        Purpose of the             The proceeds of the offering
            offering and use of        (excluding offsetting receivables)
            proceeds                   are mainly intended to finance
                                       research and development on key
                                       Company products, as well as its
                                       current requirements and in
                                       particular to:
                                         · support the international
                                       expansion of Livatag's® phase III by
                                       broadening the ReLive study into new
                                       areas to increase the recruitment
                                       rate and optimise the study's
                                       duration,
                                         · prepare Validive's® Phase III
                                       study, which follows Phase II, for
                                       which the first results were obtained
                                       on October 30, 2014,
                                         · pursue Beleodaq's® next
                                       development stage involving:
                                           · a Phase I combination study
                                       with the standard treatment for the
                                       PTCL indication as a first line
                                       treatment, and
                                           · preparing for the start of
                                       Phase III in order to validate the
                                       Marketing Authorisation in the United
                                       States for this indication and to
                                       obtain the same authorisation in
                                       Europe.


E.3        Terms and                Number of New Shares to be
           conditions of the        issued7,872,661 New Shares which may be
           offering                 increased to 9,053,560 shares in the
                                    event of full exercise of the Extension
                                    Clause and a maximum of 9,246,098 shares
                                    upon exercise of all financial
                                    instruments giving access to the
                                    Company’s share capital before November
                                    26, 2014 and the full exercise of the
                                    Extension Clause.Subscription price for
                                    the New SharesThe subscription price is
                                    EUR 4.50 per share, with a EUR 0.25 par
                                    value and EUR 4.25 of share premium, to
                                    be fully paid upon subscription,
                                    representing a face-value discount of
                                    29.02% over the closing price of the
                                    company’s share on November 14, 2014, or
                                    EUR 6.34.For shareholders holding shares
                                    of the Company in Denmark through VP
                                    Securities A/S (central depository of
                                    securities in Denmark) and investors
                                    acquiring subscription rights through
                                    NASDAQ OMX, the subscription price shall
                                    paid up in Danish Kroner (“DKK”), i.e.,
                                    on the basis of an exchange rate of
                                    DKK7.4440 for EUR 1 on November 17, 2014,
                                    DKK33.50.It is specified that the Company
                                    concluded a hedging agreement with Nordea
                                    Bank Finland Plc against any change in
                                    the Euro/DKK exchange rate between
                                    November 17, 2014 and December 16, 2014
                                    (date of settlement-delivery). In this
                                    way, any negative evolution of the DKK
                                    relative to the euro between November 17,
                                    2014 and December 16, 2014 shall form the
                                    object of a currency hedge, in order to
                                    ensure that the gross proceeds of the
                                    offer are equal to the amount mentioned
                                    in E1. It is specified for all purposes
                                    that the Company would not receive any
                                    amount in euro greater than the gross
                                    proceeds amount of the issue in case of
                                    positive evolution of the DKK relative to
                                    the euro over the same
                                    period.Preferential subscription
                                    rightsSubscription of New Shares will be
                                    reserved in priority for:
                                      · holders of existing shares registered
                                    in their securities account at the close
                                    of trading on November 21, 2014; and
                                      · purchasers of preferential
                                    subscription rights.
                                    Holders of preferential subscription
                                    rights will be entitled to subscribe:
                                      · on an irreducible basis at the rate
                                    of 1 New Share for every 4 existing share
                                    held (4 preferential subscription rights
                                    will entitle the holder of such rights to
                                    subscribe for 1 New Share at a price of
                                    EUR 4.50 per share); and
                                      · on a reducible basis the number of
                                    New Shares they wish in addition to those
                                    due to them through the exercise of their
                                    rights on a reducible basis.
                                    Preferential subscription rights will be
                                    listed and traded from November 24, 2014
                                    up until December 3, 2014 (inclusive) on
                                    the Euronext Paris and from November 24,
                                    2014 up until December 1st, 2014
                                    (inclusive) on NASDAQ OMX under ISIN code
                                    FR0012314656, it being specified that the
                                    preferential subscription rights may not
                                    be transferred between (i) Euroclear Bank
                                    SA/NV & Clearstream Banking (Luxembourg
                                    LLC) and (ii) VP Securities A/S during
                                    the subscription period (identical for
                                    both markets, i.e. from November 24, 2014
                                    to December 3, 2014).New Share
                                    subscription on NASDAQ OMXSubscription of
                                    new shares on the basis of subscription
                                    rightsHolders of existing shares admitted
                                    to the operations of VP Securities A/S as
                                    of November 21, 2014 and investors which
                                    acquire preferential subscription rights
                                    on NASDAQ OMX (the “Danish Investors”)
                                    wishing to subscribe for new shares on an
                                    irreducible basis (i.e., through the
                                    exercise of subscription rights), must
                                    pay up the subscription price for the new
                                    shares in DKK in accordance with the
                                    rules and procedures of the Danish
                                    Investor’s own account holding
                                    institution or financial intermediary no
                                    later than on December 3, 2014. Any new
                                    shares subscribed by Danish Investor’s
                                    exercise of subscription rights will be
                                    registered as temporary certificates in
                                    the Danish Investor’s account with VP
                                    Securities in a temporary ISIN
                                    FR0012327773, which will not be admitted
                                    to trading and official listing on NASDAQ
                                    OMX. Such certificates will be converted
                                    into new shares upon completion of the
                                    offering as issuance of the new
                                    shares.Subscription of new shares on the
                                    basis of reducible ordersDanish Investors
                                    having subscribed for new shares on an
                                    irreducible basis (i.e., through the
                                    exercise of subscription rights) may also
                                    request to subscribe for additional new
                                    shares by submitting a reducible order.
                                    Danish Investors wishing to place an
                                    order on a reducible basis must fill a
                                    subscription form, sign it and submit it
                                    to their own custodian bank or financial
                                    intermediary in due time allowing such
                                    custodian bank or financial intermediary
                                    to submit the order to Nordea Bank
                                    Danmark A/S before expiry of the
                                    subscription period December 3, 2014. The
                                    subscription form will be available on
                                    the Company’s website (www.onxeo.com).
                                    The subscription form must be received by
                                    Nordea Bank Danmark A/S, Corporate
                                    Actions no later than at 17.00 on
                                    December 3, 2014 and hence must be
                                    submitted to the investor’s own financial
                                    intermediary well ahead of such date.
                                    Only one subscription form per investor
                                    is allowedTheoretical value of the
                                    preferential subscription rightEUR 0.37
                                    (based on the closing price of the share
                                    on December 14, 2014, of EUR 6.34). The
                                    subscription price of the New Shares
                                    provides a discount of 24.65% from the
                                    theoretical value of the shares ex
                                    -rights.Subscription intentions of the
                                    principal shareholdersFinancière de la
                                    Montagne (which holds 8.92% of the share
                                    capital and voting rights of the Company)
                                    has irrevocably committed to (i) exercise
                                    on an irreducible basis all its 2,807,570
                                    preferential subscription rights for a
                                    total amount, including the issue
                                    premium, of EUR 3,158,514 and (ii) to
                                    place a reducible subscription order for
                                    a total amount, including the issue
                                    premium, of EUR 10,341,486 (see below).
                                    Payment of the subscription price of the
                                    New Shares subscribed on an irreducible
                                    and reducible basis will be made by
                                    offsetting the receivable related to the
                                    advance agreement signed with the Company
                                    on July 18, 2014, pursuant to the
                                    provisions of article 1289 et seq. of the
                                    French civil code (i.e. a principal
                                    amount of EUR 10 million, to which shall
                                    be added a capitalisation premium of 25%,
                                    accrued interest and a commitment fee of
                                    EUR 54,167). In the event that Financière
                                    de la Montagne could not subscribe a
                                    number of New Shares for an amount at
                                    least equivalent to that of its
                                    receivable, this balance of this latter
                                    amount shall thus be reimbursed at latest
                                    on July 31, 2015.Financière de la
                                    Montagne reserves the right to acquire
                                    the preferential subscription rights on
                                    the market and to subscribe to New Shares
                                    on an irreducible basis and/or to
                                    subscribe to New Shares on a reducible
                                    basis for an amount greater than its
                                    subscription commitment.Nyenburgh, (which
                                    holds 0.17% of the share capital and
                                    voting rights of the Company) has
                                    undertaken irrevocably to exercise on an
                                    irreducible basis all of its 55,000
                                    preferential subscription rights and to
                                    submit a reducible subscription order for
                                    a total amount, including the issue
                                    premium, of EUR 5 million.Nyenburgh
                                    reserves the right to acquire the
                                    preferential subscription rights on the
                                    market, it being specified that the
                                    amount of its investment shall not exceed
                                    its subscription commitment, i.e. EUR 5
                                    million.The Company is unaware of the
                                    intentions of the other
                                    shareholders.Capital Ventures
                                    International has irrevocably undertaken
                                    to acquire four shares prior to the
                                    accounting day November 21, 2014, in
                                    order to place an irreducible order and
                                    to place a reducible subscription order
                                    for a total amount, including the issue
                                    premium, of EUR 20 million.


                     % holding     Amount of           % of            % stake
                     (capital)        the             gross           following
                                   commitment        proceeds            the
                                    (in EUR             of              issue
                                    million)           the
(capital)(1)
                                                     issue(1)
Financière de            8.92%           13.5           33.14              14.3
%
la Montagne
Nyenburgh                0.17%              5           12.27               2.9
%
Capital                      -             20           49.09                11
%
Ventures
International

(1) In the event of full exercise of the Extension Clause and in the event that
the subscription commitments of Financière de la Montagne, of Nyenburgh and of
Capital Ventures International were fully exercised (i.e. if no shareholder
other than Financière de la Montagne, Nyenburgh and Capital Ventures
International took part in the operation).

The commitments of Nyenburgh and of Capital Ventures International are
remunerated by a commission equal to 5% of the amount that these investors have
undertaken to subscribe, with the exception of the amount of their irreducible
subscription. This commission shall be due independently of the amount of the
effective subscription of the investors in question (likely to be reduced as a
function of the demand of the holders of the preferential subscription rights).

The subscription commitments described above do not constitute a guarantee of
successful execution pursuant to article L. 225-145 of the French commercial
code. Moreover, it is hereby specified that there is no commitment to retain the
New shares.

The subscription commitments received by the Company thus represent 94.50% of
the total amount of the offer (and 92.53% of the maximum total amount of the
offer in the event of exercise of all of the instruments financial instruments
providing access to the share capital of the Company and full exercise of the
Extension Clause).

Underwriting agreement

The issuance of the New Shares will not be subject to an underwriting agreement.

The issue shall nevertheless form the object of subscription commitments of
94.50% of the gross amount of the operation (and 92.53% of the gross maximum
amount of the operation in the event of exercise of all of the financial
instruments giving access to the share capital of the Company and full exercise
of the Extension Clause).

Countries in which the capital increase will be open to the public

The offer will be open to the public in France and Denmark.

Offer restrictions

The distribution of this Prospectus, the sale of shares and preferential
subscription rights and subscription for the New Shares may be subject to
specific regulations in certain countries, including the United States of
America.

Procedure for exercising preferential subscription rights

To exercise their preferential subscription rights, holders must submit a
request to their authorised financial intermediary at any time between November
24, 2014 and December 3, 2014, and pay the applicable subscription price. Any
preferential subscription rights not exercised by the end of the subscription
period, on December 3, 2014, will automatically become null and void.

Terms of subscription

Shareholders holding registered or bearer shares: subscriptions will be accepted
by the account-holding financial intermediaries until December 3, 2014
inclusive.

Registered shareholders: subscriptions will be accepted by Société Générale
Securities Services (32, rue du Champ-de-Tir, 44312 Nantes) until December 3,
2014 inclusive.

Subscriptions paid will be centralised with Société Générale Securities
Services, who will be responsible for establishing the certificate of deposited
funds acknowledging the completion of the capital increase.

Nordea Bank Danmark A/S is the subscription agent for the rights issue in
Denmark.

Global Coordinators and Joint Bookrunners

Natixis

47 quai d’Austerlitz

75013 Paris - France

Oddo & Cie

12, boulevard de la Madeleine

75009 Paris
France

Indicative
timetable
November           AMF approval on the prospectus.Publication of a press
17, 2014           release by the Company describing the main
                   characteristics of the capital increase and the
                   availability of the Prospectus.

November           Notification of an authorisation certificate by the AMF
18, 2014           to the Financial Supervisory Authority (“FSA”)
                   (Finanstilsynet).Publication of a notice of issuance by
                   Euronext and NASDAQ OMX.

November           Publication in the French Bulletin of Mandatory Legal
19, 2014           Notices (Bulletin d’annonces légales obligatoires, BALO)
                   of an information notice relating to (i) the suspension
                   of the right of exercise of the stock options and
                   warrants and (ii) the information of the holders of stock
                   options and warrants of the main terms of the capital
                   increase.

November           Start of the suspension period for the right to transfer
20, 2014           existing shares of the Company between Euronext Paris and
                   NASDAQ OMX.

November           Resumption of the right to transfer existing shares of
24, 2014           the Company between Euronext Paris and NASDAQ
                   OMX.Commencement of the subscription period - Detachment
                   and start of trading of preferential subscription rights
                   on Euronext Paris and NASDAQ OMX.

November           Commencement of the suspension period of the right to
26, 2014           exercise stock options and warrants.

December           End of trading of the preferential subscription rights on
1, 2014            NASDAQ OMX.

December           Closing of the subscription period - End of trading of
3, 2014            the preferential subscription rights on Euronext Paris.

December           Exercise of the Extension Clause.A press release by the
12, 2014           Company announcing the subscription results.Publication
                   by Euronext Paris of the admission notice for the New
                   Shares, indicating the final amount of the capital
                   increase as well as the allotment of the reducible
                   subscriptions.

December           Issuance of the New Shares - Settlement and
16, 2014           delivery.Listing of the New Shares for trading on
                   Euronext Paris and NASDAQ OMX.

December           Resumption of the right to exercise stock options and
17, 2014           warrants.Publication in the French BALO of an information
                   notice relating to the resumption of the right to
                   exercise stock options and warrants.



E.4        Matters that                The Global Coordinators and the Joint
           might                       Bookrunners and/or their affiliates
           significantly affect        have provided and/or in the future may
           the                         provide the Company or companies within
           issue                       the Group, their shareholders or their
                                       directors and officers various banking,
                                       financial, investment, commercial and
                                       other services, for which they have
                                       received or may receive a fee.
E.5        Individual orentity         Person or entity offering to sell
           offering the                sharesPursuant to Article L. 225-206 of
           securities for sale         the French commercial code, the Company
           / Lock-up agreements        cannot subscribe for its own shares.As
                                       of November 14, 2014, the company holds
                                       21,557 shares. The preferential
                                       subscription rights detached from the
                                       Company's treasury shares will be sold
                                       on the market before the end of the
                                       subscription period, in accordance with
                                       Article L. 225-210 of the French
                                       commercial code.Company lock-up
                                       commitmentThe Company lock-up
                                       commitment to the Global Coordinators
                                       and Joint Bookrunners is from November
                                       17, 2014 and for a period of 90 days
                                       following the settlement-delivery date
                                       of the issue, subject to certain
                                       exceptions.


E.6        Amount andpercentage of                IMPACT OF THE ISSUE ON THE
           immediatedilution resultingfrom        PROPORTIONATE SHARE OF
           theoffer                               SHAREHOLDERS’ EQUITYBy way
                                                  of illustration, the impact
                                                  of the issue on the portion
                                                  per share of consolidated
                                                  shareholders’ equity
                                                  attributable to the Group
                                                  (calculated on the basis of
                                                  the consolidated
                                                  shareholders’ equity
                                                  attributable to the Group
                                                  on June 30, 2014 in the
                                                  amount of EUR 78,450,848 –
                                                  and a number of 31,461,702
                                                  shares making up the
                                                  Company's share capital
                                                  after deducting the
                                                  treasury shares) would be
                                                  as follows:


                                      Proportionate
                                         share of
                                          equity
                                        capitalon
                                      June 30, 2014
(in Euros per share)            Before            After
                               dilution        dilution (1)
Prior to the issuance              2.50                2.69
of 7,872,661 New Shares
After the issuance of              2.61                2.75
5,904,495 New Shares(2)
After the issuance of              2.83                2.96
7,872,661 New
Shares (3)
After the issuance of              2.87                3.20
9,053,560 New
Shares (4)

(1)           Taking into account the 165,419 warrants, vested or unvested,
              issued by the Company's Board on September 21, 2011, September
              13, 2012, September 19, 2013 and September 22, 2014, the stock
              options, vested or unvested, allocated by the Board on August
              25, 2010, December 16, 2010, September 21, 2011, January 26,
              2012, September 13, 2012, September 19, 2013 and September 22,
              2014 entitling subscription for 1,157,603 shares and the 148,500
              free shares allocated by the Company's Board on September 22,
              2014, as well as the share issuance rights granted in connection
              with the equity line agreement (PACEO) between the Company and
              Société Générale on January 25, 2013 giving the right to
              subscribe for a maximum amount of 1,265,000 shares on the basis
              of a theoretical exercise price of EUR 6.02.
(2)           Capital increase of at least 75% of the initial number of shares
              to be issued.
(3)           Capital increase of at least 100% of the initial number of
              shares to be issued.
(4)           Capital increase of 115% of the initial number of shares to be
              issued (full exercise of the Extension Clause).

DILUTIVE IMPACT OF THE ISSUE ON THE SHAREHOLDER

By way of illustration, the impact of the issue on a shareholder owning 1% of
the Company's share capital prior to the issue and not subscribing to the issue
(calculated on the basis of 31.490.644 shares making up the Company's share
capital at 31 October 2014) would be as follows:


                                      Shareholder's holdings in %
(in Euros per share)           Before dilution        After dilution (1)
Prior to the issuance                     1.00                      0.95
of 7,872,661 New Shares
After the issuance of                     0.84                      0.78
5,904,495 New Shares(2)
After the issuance of                     0.80                      0.75
7,872,661 New
Shares (3)
After the issuance of                     0.78                      0.73
9,053,560 New
Shares (4)

(1)        Taking into account the 165,419 warrants, vested or unvested,
           issued by the Company's Board on September 21, 2011, September 13,
           2012, September 19, 2013 and September 22, 2014, the stock options,
           vested or unvested, allocated by the Board on August 25, 2010,
           December 16, 2010, September 21, 2011, January 26, 2012, September
           13, 2012, September 19, 2013 and September 22, 2014 entitling
           subscription for 1,157,603 shares and the 148,500 free shares
           allocated by the Company's Board on September 22, 2014, as well as
           the share issuance rights granted in connection with the equity
           line agreement (PACEO) between the Company and Société Générale on
           January 25, 2013 giving the right to subscribe for a maximum of
           1,265,000 shares.
(2)        Capital increase of at least 75% of the initial number of shares to
           be issued.
(3)        Capital increase of at least 100% of the initial number of shares
           to be issued.
(4)        Capital increase of 115% of the initial number of shares to be
           issued (full exercise of the Extension Clause).

DILUTIVE IMPACT OF THE ISSUE ON THE SHAREHOLDER

By way of illustration, the impact of the issue on a shareholder owning 1% of
the Company's share capital prior to the issue and not subscribing to the issue
(calculated on the basis of 31.490.644 shares making up the Company's share
capital at 31 October 2014) would be as follows:


                                      Shareholder's holdings in %
(in Euros per share)           Before dilution        After dilution (1)
Prior to the issuance                     1.00                      0.95
of 7,872,661 New Shares
After the issuance of                     0.84                      0.78
5,904,495 New Shares(2)
After the issuance of                     0.80                      0.75
7,872,661 New
Shares (3)
After the issuance of                     0.78                      0.73
9,053,560 New
Shares (4)

(1)       Taking into account the 165,419 warrants, vested or unvested, issued
          by the Company's Board on September 21, 2011, September 13, 2012,
          September 19, 2013 and September 22, 2014, the stock options, vested
          or unvested, allocated by the Board on August 25, 2010, December 16,
          2010, September 21, 2011, January 26, 2012, September 13, 2012,
          September 19, 2013 and September 22, 2014 entitling subscription for
          1,157,603 shares and the 148,500 free shares allocated by the
          Company's Board on September 22, 2014, as well as the share issuance
          rights granted in connection with the equity line agreement (PACEO)
          between the Company and Société Générale on January 25, 2013 giving
          the right to subscribe for a maximum of 1,265,000 shares.
(2)       Capital increase of at least 75% of the initial number of shares to
          be issued.
(3)       Capital increase of at least 100% of the initial number of shares to
          be issued.
(4)       Capital increase of 115% of the initial number of shares to be
          issued (full exercise of the Extension Clause).


E.7        Expensescharged to                  Not Applicable.
           the investorby the Issuer

NOT FOR DISTRIBUTION IN THE UNITED STATES OF AMERICA, CANADA, AUSTRALIA AND
JAPAN

NOT FOR DISTRIBUTION DIRECTLY OR INDIRECTLY IN THE UNITED STATES OF AMERICA,
CANADA, AUSTRALIA OR JAPAN

Source: Onxeo S.A.
Onxeo S.A.
Judith Greciet
CEO
j.greciet@onxeo.com
or
Alize RP
Caroline Carmagnol / Sophie Colin
+33 6 64 18 99 59 / +33 6 31 13 76 20
caroline@alizerp.com / scolin@alizerp.com
or
Nicolas Fellmann, +33 1 45 58 76 00
CFO
n.fellmann@onxeo.com

Attachments

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