BIOTIE ANNOUNCES START OF SYN120 PHASE 2A TRIAL IN PARKINSON'S DISEASE DEMENTIA AND PROVIDES OUTLOOK UPDATE FOR NEAR TERM PIPELINE EVENTS

BIOTIE THERAPIES CORP.     STOCK EXCHANGE RELEASE                  23 December,
2014 at 9.30 a.m.

BIOTIE ANNOUNCES START OF SYN120 PHASE 2A TRIAL IN PARKINSON'S DISEASE DEMENTIA
AND PROVIDES OUTLOOK UPDATE FOR NEAR TERM PIPELINE EVENTS

Biotie Therapies Corp. ("Biotie") announces the start of the Phase 2a clinical
study of SYN120, a 5-HT6/5-HT2A antagonist, in patients with Parkinson's disease
dementia (PDD). The study is being funded by The Michael J. Fox Foundation
(MJFF).

The SYNAPSE study is an 80 patient, Phase 2a, randomized, double-blind, multi-
center, placebo-controlled trial in patients with Parkinson's disease dementia.
Patients will be randomized 1:1 to placebo or SYN120 dosed once daily over a 16
week treatment period. In addition to assessing safety and tolerability, the
main focus of the study is to establish efficacy of SYN120 on cognition using
the Cognitive Drug Research (CDR) Computerized Cognition Battery as the primary
efficacy endpoint. The study will be conducted by the Parkinson Study Group
(PSG) at approximately 12 sites in the United States specializing in cognitive
dysfunction in Parkinson's disease. Biotie and the PSG will share responsibility
for the design and execution of the study, and top-line results of the study are
expected in the second half of 2016. Biotie retains the rights to SYN120 and
will be able to use data from the MJFF-funded study for any future regulatory
submission.

Final preparations are ongoing for an investigator-sponsored Phase 2 study of
Biotie's monoclonal anti-VAP-1 antibody BTT1023 in primary sclerosing
cholangitis. The BUTEO study, previously expected to commence by the end of
2014, is now expected to start in Q1 2015.

Data are currently being analyzed from the NIDA-sponsored Phase 2 study
investigating Biotie's DBH inhibitor nepicastat in cocaine dependence. Top-line
results from the study are expected to be available during Q1 2015.



Turku, 23 December 2014

Biotie Therapies Corp.

Timo Veromaa
President and CEO

Further information:

For further information, please contact:

Virve Nurmi, Investor Relations Manager
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

Distribution:

NASDAQ OMX Helsinki Ltd
Main media
www.biotie.com

ABOUT BIOTIE

Biotie is a specialized drug development company focused on products for
neurodegenerative and psychiatric disorders. Biotie's development has delivered
Selincro (nalmefene) for alcohol dependence, which received European marketing
authorization in 2013 and is currently being rolled out across Europe by partner
Lundbeck. The current development products include tozadenant for Parkinson's
disease, which is transitioning into Phase 3 development, and three additional
compounds which are in Phase 2 development for cognitive disorders including
Parkinson's disease dementia, cocaine dependence, and primary sclerosing
cholangitis (PSC), a rare fibrotic disease of the liver.


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