Merger between OnCore and Tekmira includes development of NVP018 for the treatment of Hepatitis B

US biotechnology company OnCore Biopharma, Inc. (OnCore), which has licensed
NeuroVive’s drug candidate NVP018 for the treatment of chronic Hepatitis B virus
infection (HBV), has agreed to merge with Canadian listed RNAi therapeutics
company Tekmira Pharmaceuticals Corporation (Tekmira). OnCore would continue as
a subsidiary of Tekmira, and the licensing agreement for NVP018 between
NeuroVive and OnCore will remain in force following the merger as the combined
company continues to work in the HBV area.
OnCore (http://www.oncorebiopharma.com/) and Tekmira (http://www.tekmira.com/)
announced on January 11, 2015 that they have agreed to merge; the merger itself
is subject to Tekmira stockholder approval and other customary closing
conditions. A joint press release issued by the two companies states, among
other things, that they intend to advance a robust pipeline of assets, including
NVP018, with the ultimate goal of delivering a curative regimen for HBV.
Hepatitis B is a major global health problem with up to 350 million people
chronically infected.  Most currently available therapies aim to suppress this
infection but do not lead to a cure in the overwhelming majority of patients.
Please note that NVP018 is referred to as OCB-030 in OnCore’s portfolio of
product candidates.

“I walk away with a very positive view of the merger as the synergies between
the companies’ technology platforms increases the probability of their success
in developing a clinically effective treatment for Hepatitis B and may also
reduce the time to market of such a treatment,” commented NeuroVive’s COO Jan
Nilsson.

As previously communicated, NeuroVive has outlicensed its candidate drug NVP018
to OnCore for the oral treatment of Hepatitis B. Under the licensing agreement
with OnCore, NeuroVive’s remuneration consists of an upfront payment alongside a
number of conditional payments based on pre-determined milestones, including
sales targets. In addition, NeuroVive will receive incremental royalty payments
based on gross revenue from future sales of NVP018. The exact terms of the
agreement are not disclosed. The license agreement is unaffected by the merger
agreement and will remain in force following the closing of the merger.

Current status of NeuroVive’s projects and drug candidates

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CicloMulsion®
NeuroVive’s product CicloMulsion® is the first cyclophilin inhibitor developed
for the treatment of reperfusion injury. The product’s potential in the
treatment of myocardial infarction is currently being evaluated in a clinical
phase III study. The last of a total of 972 patients was enrolled on 16 February
2014. The results of the study are due to be announced in 2015 following the
completion of the one-year follow-up of all patients and the analysis of the
study data. CicloMulsion® will also be evaluated in a number of clinical phase
II studies for the treatment of other acute heart and kidney injury within the
framework of the collaboration with Hospices Civils de Lyon and Skåne University
Hospital in Lund, Sweden.

NeuroSTAT®
NeuroVive is developing NeuroSTAT® for the treatment of patients with moderate
or severe traumatic brain injury. NeuroSTAT® is currently being evaluated in a
clinical phase IIa study at Copenhagen University Hospital. The study focuses on
safety and pharmacokinetics, and 9 of 20 planned patients have been enrolled so
far. A phase III study is currently being planned and designed. NeuroVive has
secured orphan drug designation for NeuroSTAT® for moderate and severe traumatic
brain injury in the US and EU, which implies market exclusivity for seven years
in the US and ten years in the EU, from the date NeuroVive obtains market
authorization.

NVP019
NVP019 is NeuroVive’s primary drug candidate in the company’s new portfolio of
potent cyclophilin inhibitors belonging to a family of molecules known as
Sangamides based on a new and unique polyketide engineering technology. NVP019
is being developed as the next generation cyclophilin inhibitor for reperfusion
injury in heart attack, but also for other acute conditions where general
protection of vital organs is central to counteracting the progression of the
disease. An intravenous formulation will be evaluated for this purpose in
collaboration with external parties such as Hospices Civils de Lyon within the
framework of the OPeRa program.

NVP018
NVP018 is an oral formulation based on the same active substance as NVP019. It
has been developed for treatment of Hepatitis B and was outlicensed to OnCore
Biopharma, Inc. (www.oncorebiopharma.com) in September 2014. OnCore Biopharma
has termed the drug candidate OCB-030.

Other products
More information about all products developed by NeuroVive can be found at
http://www.neurovive.se/index.php/en/research-development/research-overview

About NeuroVive Pharmaceutical
NeuroVive Pharmaceutical AB (publ), a leading mitochondrial medicine company, is
developing a portfolio of products to treat acute cardiovascular and
neurological conditions through mitochondrial protection. These medical
conditions are characterized by a pressing medical need and have no approved
pharmaceutical treatment options at present. NeuroVive’s products CicloMulsion®
(heart attack) and NeuroSTAT® (traumatic brain injury) are currently being
evaluated in phase III and phase II studies, respectively. NeuroVive’s research
programs also include products for the treatment of brain cell injury in stroke
patients, and drug candidates for cellular protection and treating mitochondria
-related energy regulation diseases. NeuroVive’s shares are listed on NASDAQ
OMX, Stockholm, Sweden.

For Investor Relations and media questions, please contact:
Ingmar Rentzhog, Laika Consulting (http://www.laika.se), Tel: +46 (0)46 275 62
21 or ir@neurovive.se
It is also possible to arrange an interview with NeuroVive’s CEO Mikael
Brönnegård or COO Jan Nilsson at the above contact.

NeuroVive Pharmaceutical AB (publ)
Medicon Village, SE-223 81 Lund, Sweden
Tel: +46 (0)46 275 62 20 (switchboard), Fax: +46 (0)46 888 83 48
info@neurovive.se, www.neurovive.se

NeuroVive Pharmaceutical AB (publ) is required to publish the information in
this news release under The Swedish Securities Market Act. The information was
submitted for publication on 19 January 2014, at 3.30 p.m. CET.
NeuroVive Pharmaceutical AB (publ) - the mitochondrial medicine company. The
company is listed on NASDAQ OMX Stockholm, Small Cap, under the ticker symbol
NVP. The share is also traded on the OTC market in the US. NeuroVive
Pharmaceutical (OTC: NEVPF) trades on the OTC Grey Market. Investors can find
Real-Time quotes and market information for the company
at www.otcmarkets.com/stock/NEVPF/quote (http://htt://www.otcmarkets.com/stock/N
E 
VPF/quot)