Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The following individuals, who are all Directors of the Company, have notified
us that they have purchased AstraZeneca PLC Ordinary Shares of $0.25 each or
AstraZeneca American Depositary Shares (ADSs).

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

Name of     Date of       Date of   Number of shares purchased  Purchase price
Director    notification  purchase
Bruce       28 April      27 April  600                         $71.03
Burlington  2015          2015
Graham      28 April      28 April  1,100                       4606p
Chipchase   2015          2015
Shriti      29 April      29 April  3,500                       4563p
Vadera      2015          2015

A C N Kemp

Company Secretary

29 April 2015