Holding(s) in Company


+---------+----++++------------+
|               |              |
+---------+----++++------------+
|               |              |
+---------+----++++------------+
|                              |
+---------+----++++------------+
|TR-1:                         |
|NOTIFICATION                  |
|OF MAJOR                      |
|INTEREST IN                   |
|SHARESi                       |
+---------+----++++------------+
|                |             |
+---------+----++++------------+
|1. Identity of  |AstraZeneca  |
|the issuer or   |plc          |
|the underlying  |             |
|  issuer        |             |
|  of existing   |             |
|shares to       |             |
|which voting    |             |
|rights are      |             |
|  attached:ii   |             |
+---------+----++++------------+
|2 Reason for                  |
|the                           |
|notification                  |
|(please tick                  |
|the                           |
|appropriate                   |
|box or boxes):                |
+---------+----++++------------+
|An               |     X      |
|acquisition or   |            |
|disposal of      |            |
|voting rights    |            |
+---------+----++++------------+
|An               |            |
|acquisition or   |            |
|disposal of      |            |
|qualifying       |            |
|financial        |            |
|instruments      |            |
|which may        |            |
|result   in      |            |
|the              |            |
|acquisition of   |            |
|shares already   |            |
|issued to        |            |
|which voting     |            |
|rights are       |            |
|attached         |            |
+---------+----++++------------+
|An               |            |
|acquisition or   |            |
|disposal of      |            |
|instruments      |            |
|with similar     |            |
|economic         |            |
|effect to        |            |
|qualifying       |            |
|financial        |            |
|instruments      |            |
+---------+----++++------------+
|An   event       |            |
|changing the     |            |
|breakdown of     |            |
|voting rights    |            |
+---------+----++++------------+
|Other    |       |            |
|(please  |       |            |
|specify):|       |            |
+---------+----++++------------+
|3. Full name  |The            |
|of person(s)  |Capital        |
|subject to    |Group          |
|the           |Companies,     |
|  notification|Inc.           |
|obligation:   |               |
|iii           |               |
+---------+----++++------------+
|4. Full name  |See            |
|of            |Schedule A     |
|shareholder(s)|               |
|  (if         |               |
|different from|               |
|3.):iv        |               |
+---------+----++++------------+
|5. Date of the|1   June       |
|transaction   |2015           |
|and date   on |               |
|  which the   |               |
|threshold is  |               |
|crossed or    |               |
|  reached:   v|               |
+---------+----++++------------+
|6. Date on    |2   June       |
|which issuer  |2015           |
|notified:     |               |
+---------+----++++------------+
|7.            |Below 3%       |
|Threshold(s)  |               |
|that is/are   |               |
|crossed   or  |               |
|  reached: vi,|               |
|  vii         |               |
+---------+----++++------------+
|         |    ||||            |
+---------+----++++------------+

+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|8. Notified
|
|details:
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|A: Voting rights
|
|attached to shares
|
|viii, ix
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Class/type of  |Situation             |Resulting
|
|  shares       |previous              |situation
|
|  if   possible|  to the              |after the
|
|using          |triggering            |triggering
|
|  the ISIN CODE|  transactio          |transaction
|
|               |n                     |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Number            |Number            |Number|Number of    |% of               |
|  of              |  of              |  of  |voting       |voting             |
|  Shares          |  Voting          |shares|  rights     |rights x           |
|                  |  Rights          |      |             |                   |
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Direct           |Direct  |Indirect|Direct  |Indirect    |
|                 |xi      |xii     |        |            |
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Ordinary       |31,704,772|31,704,772 |          |        |          |
|2.4088%     |
|Shares(ISIN:   |          |           |          |        |30,437,552|  |
|
|GB0009895292)  |          |           |          |        |          |  |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|ADRs   (ISIN:  |7,433,161 |7,433,161  |          |        |          |
|0.5884%     |
|US0463531089)  |          |           |          |        |7,435,104 |  |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|B: Qualifying
|
|Financial
|
|Instruments
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Resulting situation
|
|  after the
|
|triggering
|
|transaction
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Type of financial |Expiration      |Exercise/            |Number of    |% of
|
|  instrument      |  date          |  Conversio          |voting       |voting
|
|                  |xiii            |n Period             |  rights     |  right
|
|                  |                |xiv                  |that may     |s
|
|                  |                |                     |be           |
|
|                  |                |                     |  acquired   |
|
|                  |                |                     |if the       |
|
|                  |                |                     |  instrumen  |
|
|                  |                |                     |t is         |
|
|                  |                |                     |  exercised  |
|
|                  |                |                     |/ converted  |
|
|                  |                |                     |.            |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|                  |                |                     |             |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|C: Financial
|
|Instruments with
|
|similar economic
|
|effect to
|
|Qualifying
|
|Financial
|
|Instruments xv, xvi
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Resulting situation
|
|  after the
|
|triggering
|
|transaction
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Type of financial|Exercise|Expiration|Exercise/  |Number of           |% of
|
|  instrument     |price   |date xvii |  Conversio|voting              |voting
|
|                 |        |          |n period   |rights              |rights
|
|                 |        |          |xviii      |instrument          |xix, xx
|
|                 |        |          |           |refers to           |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|                 |        |          |           |
|Nominal|Delta |
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|                  |       |
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Total (A+B+C)
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|Number of voting                            |Percentage
|
|rights                                      |of
|
|                                            |voting
|
|                                            |rights
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|37,872,656                                  |2.9972%
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+
|               | ||       |        | ||     |    |       ||          ||||     |
|
+---------------+-++-------+--------+-++-----+----+-------++----------++++-----+
------+

+-----------------------------+-----------------------+-------------------------
-+
|9. Chain of controlled undertakings   through which the voting rights and/or
the|
|  financial instruments are effectively held, if applicable: xxi
|
+-----------------------------+-----------------------+-------------------------
-+
|See Schedule A
|
+-----------------------------+-----------------------+-------------------------
-+
|
|
+-----------------------------+-----------------------+-------------------------
-+
|Proxy Voting:
|
+-----------------------------+-----------------------+-------------------------
-+
|10. Name of the proxy holder:                        |
|
+-----------------------------+-----------------------+-------------------------
-+
|11. Number of voting rights proxy   holder will cease|
|
|  to hold:                                           |
|
+-----------------------------+-----------------------+-------------------------
-+
|12. Date on which proxy holder will   cease to hold  |
|
|  voting rights:                                     |
|
+-----------------------------+-----------------------+-------------------------
-+
|
|
+-----------------------------+-----------------------+-------------------------
-+
|  13. Additional information:|
|
|                             |
|
+-----------------------------+-----------------------+-------------------------
-+
|14. Contact name:            |
|
+-----------------------------+-----------------------+-------------------------
-+
|15. Contact telephone number:|
|
+-----------------------------+-----------------------+-------------------------
-+
|                             |                       |
|
+-----------------------------+-----------------------+-------------------------
-+

                                                       Schedule A

As of 1 June 2015

AstraZeneca PLC

                          Number   of Shares  Percent   of Outstanding

The   Capital Group       37,872,656          2.997%
Companies, Inc. (“CG”)
holdings
Holdings by CG
Management Companies and
Funds:
Capital   Guardian Trust  5,512,014           0.436%
Company
Capital   International   165,100             0.013%
Limited
Capital   International   154,992             0.012%
Sàrl
Capital   International,  72,900              0.006%
Inc.
Capital   Research and    31,967,650          2.530%
Management Company

Attachments

06035261.pdf