Issue and repurchase of class C shares

Uppsala, Sweden - June 17, 2015 - Orexo AB announces that the company has
resolved to issue and immediately thereafter repurchase 135,000 class C shares.
The shares are issued and repurchased in accordance with the long-term incentive
program, LTIP 2015, which was adopted by the annual general meeting on 15 April
2015.

Danske Bank subscribes for the entire issue of new class C shares at a
subscription price of SEK 0.40 per share, equal to the quota value of the
shares. The entire issue of class C shares will thereafter be repurchased by
Orexo for SEK 0.40 per share.

The purpose of the share issue is to enable the future delivery of ordinary
shares to participants in LTIP 2015. The class C shares will be converted into
ordinary shares prior to delivery to qualifying participants in LTIP 2015. The
class C shares do not entitle to dividends.

For further information, please contact:
Henrik Juuel, EVP and Chief Financial Officer
Tel: +46 (0)18-780 88 00, E-mail: ir@orexo.com

About Orexo
Orexo is a specialty pharmaceutical company commercializing its proprietary
product Zubsolv® for maintenance treatment of opioid dependence in the US.
Zubsolv is an advanced formulation of buprenorphine and naloxone using Orexo’s
unique knowledge and expertise in sublingual drug delivery. R&D is focusing on
reformulation of known substances to new improved products that meet great unmet
medical needs by using its patented proprietary technologies. Orexo’s share is
listed on Nasdaq Stockholm Exchange Mid Cap (STO: ORX) and is available as ADRs
on OTCQX (ORXOY) in the US. Orexo’s global headquarters and R&D are based in
Uppsala, Sweden.

For information about Orexo please visit www.orexo.com