Holding(s) in Company


+-------------++++--------------+
|                               |
+-------------++++--------------+
|TR-1:                          |
|NOTIFICATION                   |
|OF MAJOR                       |
|INTEREST IN                    |
|SHARESi                        |
+-------------++++--------------+
|               |               |
+-------------++++--------------+
|1. Identity of |AstraZeneca PLC|
|the issuer or  |               |
|the underlying |               |
|issuer of      |               |
|existing       |               |
|shares to      |               |
|which voting   |               |
|rights are     |               |
|attached:ii    |               |
+-------------++++--------------+
|2 Reason for                   |
|the                            |
|notification                   |
|(please tick                   |
|the                            |
|appropriate                    |
|box or boxes):                 |
+-------------++++--------------+
|An acquisition  |      X       |
|or disposal of  |              |
|voting rights   |              |
+-------------++++--------------+
|An acquisition  |              |
|or disposal of  |              |
|qualifying      |              |
|financial       |              |
|instruments     |              |
|which may       |              |
|result in the   |              |
|acquisition of  |              |
|shares already  |              |
|issued to       |              |
|which voting    |              |
|rights are      |              |
|attached        |              |
+-------------++++--------------+
|An acquisition  |              |
|or disposal of  |              |
|instruments     |              |
|with similar    |              |
|economic        |              |
|effect to       |              |
|qualifying      |              |
|financial       |              |
|instruments     |              |
+-------------++++--------------+
|An event        |              |
|changing the    |              |
|breakdown of    |              |
|voting rights   |              |
+-------------++++--------------+
|Other (please|  |              |
|specify):    |  |              |
+-------------++++--------------+
|3. Full name  |The Capital     |
|of person(s)  |Group           |
|subject to the|Companies,      |
|notification  |Inc.            |
|obligation:   |                |
|iii           |                |
+-------------++++--------------+
|4. Full name  |See Schedule    |
|of            |A               |
|shareholder(s)|                |
|(if different |                |
|from 3.):iv   |                |
+-------------++++--------------+
|5. Date of the|15 July 2015    |
|transaction   |                |
|and date on   |                |
|which the     |                |
|threshold is  |                |
|crossed or    |                |
|reached: v    |                |
+-------------++++--------------+
|6. Date on    |16 July 2015    |
|which issuer  |                |
|notified:     |                |
+-------------++++--------------+
|7.            |Above 3%        |
|Threshold(s)  |                |
|that is/are   |                |
|crossed or    |                |
|reached: vi,  |                |
|vii           |                |
+-------------++++--------------+
|             ||||              |
+-------------++++--------------+

+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|8. Notified details:
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|A: Voting rights attached
|
|to shares viii, ix
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Class/type of shares if|Situation             |Resulting
|
|possible using the ISIN|previous to           |situation
|
|CODE                   |the                   |after the
|
|                       |triggering            |triggering
|
|                       |transaction           |transaction
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Number of Shares         |Number of          |Number of|Number of|% of
|
|                         |Voting             |shares   |voting   |voting
|
|                         |Rights             |         |rights   |rights x
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Direct                  |Direct   |Indirect|Direct     |Indirect|
|                        |xi       |xii     |           |        |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Ordinary(GB0009895292) |30,372,883|30,372,883 |         |        |30,472,596|
|2.4115%                 |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|                       |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|ADRs(us0463531089)     |7,452,630 |7,452,630  |         |        |7,453,217 |
|0.5898%                 |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|B: Qualifying Financial
|
|Instruments
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Resulting situation after
|
|the triggering transaction
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Type of financial        |Expiration       |Exercise/           |Number of
|% of                     |
|instrument               |date xiii        |Conversion          |voting
|voting                   |
|                         |                 |Period xiv          |rights
|rights                   |
|                         |                 |                    |that may     |
|
|                         |                 |                    |be           |
|
|                         |                 |                    |acquired     |
|
|                         |                 |                    |if the       |
|
|                         |                 |                    |instrument   |
|
|                         |                 |                    |is           |
|
|                         |                 |                    |exercised/   |
|
|                         |                 |                    |converted.   |
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|n/a                      |                 |                    |             |
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|C: Financial Instruments
|
|with similar economic
|
|effect to Qualifying
|
|Financial Instruments xv,
|
|xvi
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Resulting situation after
|
|the triggering transaction
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Type of financial       |Exercise |Expiration|Exercise/ |Number of           |%
of voting rights xix, xx|
|instrument              |price    |date xvii |Conversion|voting              |
|
|                        |         |          |period    |rights              |
|
|                        |         |          |xviii     |instrument          |
|
|                        |         |          |          |refers to           |
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|n/a                     |         |          |          |
|Nominal|Delta             |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|                         |        |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Total (A+B+C)
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|Number of voting rights                                |Percentage
|
|                                                       |of voting
|
|                                                       |rights
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|37,925,813                                             |3.0013%
|
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+
|                       |||        |        | ||        ||       ||
||||     |                  |
+-----------------------+++--------+--------+-++--------++-------++---------
-++++-----+------------------+

+--------------+++
|9. Chain of     |
|controlled      |
|undertakings    |
|through which   |
|the voting      |
|rights and/or   |
|the financial   |
|instruments     |
|are             |
|effectively     |
|held, if        |
|applicable:     |
|xxi             |
+--------------+++
|See Schedule A  |
+--------------+++
|                |
+--------------+++
|Proxy Voting:   |
+--------------+++
|10. Name of    ||
|the proxy      ||
|holder:        ||
+--------------+++
|11. Number of  ||
|voting rights  ||
|proxy holder   ||
|will cease to  ||
|hold:          ||
+--------------+++
|12. Date on    ||
|which proxy    ||
|holder will    ||
|cease to hold  ||
|voting rights: ||
+--------------+++
|                |
+--------------+++
|13. Additional| |
|information:  | |
+--------------+++
|14. Contact   | |
|name:         | |
+--------------+++
|15. Contact   | |
|telephone     | |
|number:       | |
+--------------+++
|              |||
+--------------+++

Schedule A

As of 15 July 2015

AstraZeneca PLC

                          Number of Shares  Percent of Outstanding

The Capital Group         37,925,813        3.001%
Companies, Inc. (“CG”)
holdings
Holdings by CG
Management Companies and
Funds:
Capital Guardian Trust    5,587,791         0.442%
Company
Capital International     171,800           0.014%
Limited
Capital International     158,992           0.013%
Sàrl
Capital International,    72,900            0.006%
Inc.
Capital Research and      31,934,330        2.527%
Management Company

Attachments

07175126.pdf