Director/PDMR Shareholding


Transactions by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 25 September 2015, Dr Sean Bohen, EVP, Global Medicines Development & Chief
Medical Officer, a person discharging managerial responsibilities, was granted
awards under the terms of the AstraZeneca Performance Share Plan (AZPSP) and the
AstraZeneca Restricted Share Plan (AZRSP) over the Company's American Depositary
Shares (ADSs). Two ADSs equal one Ordinary Share of US$0.25 each.

+------+-------------+--------------------------+---------------------+
|Name  |ADSs         |ADSs   awarded under AZRSP|Award   price per ADS|
|      |awarded under|                          |                     |
|      |AZPSP        |                          |                     |
+------+-------------+--------------------------+---------------------+
|Sean  |16,003       |51,802                    |$32.32               |
|Bohen |             |                          |                     |
+------+-------------+--------------------------+---------------------+

The AZPSP award is subject to a combination of performance measures focused on
AstraZeneca's scientific, commercial and financial performance assessed over a
three-year performance period (1 January 2015 to 31 December 2017). The award
will vest on the third anniversary of the date on which it was granted.

The AZRSP award will vest, subject to Dr Bohen's continued employment with the
Company, as follows:

25,901 ADSs will vest on 25 September 2016
25,901 ADSs will vest on 25 September 2017


A C N Kemp
Company Secretary
28 September 2015

Attachments

09286996.pdf