Coherus and Baxalta Announce CHS-0214 (Investigational Etanercept Biosimilar) Met Primary Efficacy Endpoint in Phase 3 Rheumatoid Arthritis Clinical Study (RaPsODY)
January 11, 2016 06:45 ET
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Cadiz, Inc.;iDreamSky Technology Limited ;Impact Telecom;CNS Response, Inc.;Akers Biosciences, Inc.;Inteliquent, Inc.;Meridian Audio;Triax,Unitron Group;Triax;Unitron Group;Global Invacom Group Limited;MARUSYS;Diamondback Energy, Inc.;Fifth Street Senior Floating Rate Corp.;Fujitsu America, Inc.;CB Financial Services, Inc.;Diamondback Energy, Inc.;First Citizens Bancorporation, Inc.;ZAIS Group, LLC;Udi's Gluten Free;LinnCo, LLC;Blue Bird Corporation;CB Financial Services, Inc.;Nielsen;Rose Rock Midstream;Western Refining, Inc.;CB Financial Services, Inc.;7digital;Horizon Technology Finance Corporation;Bernstein Litowitz Berger & Grossmann LLP ;Fifth Street Senior Floating Rate Corp.;LinnCo, LLC;LinnCo, LLC;Globe Specialty Metals Inc. ;The Channel Company;American Water Works Company, Inc.;Top Ships, Inc.;Energy Fuels, Inc.;ForceField Energy, Inc.;Profire Energy, Inc.;InterCloud Systems, Inc.;Lattice, Inc.;GlyEco, Inc.;Quadrant 4 System Corp.;Bitcoin Shop, Inc.;Iveda Solutions, Inc., Direct Insite Corp., Drone Aviation Holding Corp., Big North Graphite Corp., The Coin Tree;Starstream Entertainment, Inc., Giggles N' Hugs, Inc., StationDigital Corp., Exeo Entertainment, Inc., I-Tap, Inc.;Clal Biotechnology Industries Ltd.;Presbyterian Senior Living;Actinium Pharmaceuticals, Inc.;Pac-12 Networks;NETGEAR, Akers Biosciences, TOP Ships;Rose Rock Midstream, L.P.;LinnCo, LLC;SoftIron;Cosmodyne, LLC;Cosmodyne, LLC;aioTV;Fyffes;Targa Resources Corp.;Western Refining, Inc.;Targa Resources Corp. ;Diamondback Energy, Inc.;Azteca America;Fundacion Azteca America;RBC Wealth Management;RBC Wealth Management;Targa Resources Corp.;BBC Worldwide;Market America, Inc. & SHOP.COM;LinnCo, LLC;eBay;Baker Donelson;Riverside Bank;Viper Energy Partners LP;Takeda Pharmaceutical Company Limited;OxySure Systems, Inc.;Southwest Airlines;LinnCo, LLC;Berkshire Hills Bancorp, Inc.;The Care and Concern Free Health Clinic;LifeLock, Inc.;Diamondback Energy, Inc.;Panasonic Corporation;Actinium Pharmaceuticals;SemGroup Corporation;Rose Rock Midstream L.P.;Fifth Street Senior Floating Rate Corp.;Valley Community Bank ;Actinium Pharmaceuticals, Inc.;Aptys Solutions;Cancer Genetics, Inc. ;E4 Computer Engineering;NXP Semiconductors N.V.;Bristol-Myers Squibb Company, Pfizer Inc.;Profire Energy;BNC Bancorp;Bigstock;DCR Strategies Inc. | TruCash;Akers Biosciences Inc.;OxySure Systems, Inc.;NETGEAR;TESARO, Inc.;Lattice Incorporated;Perritt Capital Management;Merck;Holland;Bristol-Myers Squibb;GlyEco, Inc.;LinnCo, LLC;The Home Depot;Lionbridge Technologies, Inc.;NatureWorks;TriQuint Semiconductor, Inc. ;Perspecta Trust LLC ;Fluor Corporation ;Rose Rock Midstream, L.P.;j2 Global;INC Research, Inc. ;Targa Resources Corp.;Holland;Women's Health USA;BillerudKorsnas AB;Oregon Health & Science University;LinnCo, LLC ;Y-TEC;Beyond Semiconductor;Trulia, Inc.;Holland;Diamondback Energy, Inc.;Federal Home Loan Bank of Seattle ;Phoenix Bancorp, Inc.;State Investors Bancorp, Inc. ;LinnCo, LLC;Akers Biosciences, Inc.;Sensory, Inc.;Targa Resources Corp.;American Red Cross;ProSyst;Otsuka Pharmaceutical Development & Commercialization, Inc.;Fifth Street Senior Floating Rate Corp.;Leapfrog;Phoenix Bancorp, Inc.;Cash Connect;Loomis;OnCore Biopharma, Inc.;Invetech Pty Ltd;Giggles N' Hugs, Inc.;LINN Energy, LLC;Princess Grace Hospital;Jack I. Zwick, Esq.;eWorld Companies, Inc.;Diamondback Energy, Inc.;NeuroBioPharm Inc.;Targa Resources Corp.;All Medical Solutions;The Medical Alliance, Inc.;Holland;SQN Banking Systems;Energy Fuels, Inc., Trecora Resources, Zivo Bioscience, Inc., AV Therapeutics, Inc., Lattice, Inc.;Targa Resources Corp. ;Cell Therapy Catapult;Allpoint Network;Targa Resources Partners LP;Rose Rock Midstream, L.P. ;Targa Resources Partners LP;ForceField Energy Inc.;Rose Rock Midstream, L.P.;Bristol Myers-Squibb;LinnCo, LLC;MaxLinear, Inc.;LinnCo, LLC;Acasti Pharma Inc.;Discovery Center of Idaho ;Courier Corporation ;QEST;LinnCo, LLC;BMV Group;Diamondback Energy, Inc.;Facilis Technology;Expedia, Inc.;Targa Resources Corp.;Viper Energy Partners LP;BMC Software, Inc. ;Centrosolar America, Inc.;Hanse Orga;Diamondback Energy, Inc.;OncoSec Medical Inc.;Stemgent;RM Auctions;LinnCo, LLC;AV Therapeutics, Inc.;Kyocera Communications Inc.;Walgreens;Liberty Mutual Insurance;Rose Rock Midstream, L.P.;Qualys, Inc.;Rose Rock Midstream;SemGroup Corporation;Reddaway;Federal Home Loan Bank of Seattle;MaxLinear, Inc.;Targa Resources Partners LP;NantHealth;LinnCo, LLC;thePlatform;Alliance Bancorp, Inc. of Pennsylvania;American Airlines Center;Bell Helicopter;Northpointe Bank;YRC Freight;Trading Technologies;OptionsCity Software;Orc;Quadrant 4 Systems Corp;OxySure Systems Inc;Lattice Inc.;Asia Pacific Stock Exchange;Inovalon;Nintendo Co., Ltd.;GridPoint;Holland;Pacific Coast Producers;Acasti Pharma Inc.;Noble Markets;Courier Corporation;LinnCo, LLC, Quantum Energy Partners ;YRC Freight;Rose Rock Midstream;CUR Media, Legacy Education Alliance, Apollo Medical Holdings;Fujifilm Holdings Corporation;Intrexon Corporation;Bitcoin Shop Inc.;Towers Watson & Co;Servier;Sporting Kansas City;LinnCo, LLC ;OxySure Systems, Inc.;Comptel Oyj;LinnCo, LLC;Putnam County Savings Bank;Outbrain Inc.;Squalan Natural Health B.V.;Lattice Incorporated;Trinity Health;Buena Vida Media;1347 Property Insurance Holdings, Inc., Cancer Genetics, Inc., Galectin Therapeutics, Inc., OxySure Systems, Inc., TOP Ships, Inc.;Asure Software, Inc.;CUR Media, Inc.;Bitcoin Shop, Inc.;Giggles N� Hugs, Inc.;Vapir Enterprises, Inc. ;Lightbridge Corp.;Profire Energy, Inc.;Lattice, Inc.;StationDigital, Inc.;Texas Rare Earth Resources, Inc.;Cardio3 BioSciences;Akers Biosciences, Inc., Arch Therapeutics, Inc., Zivo Bioscience, Inc., AV Therapeutics, Inc., Legacy Education Alliance, Inc.;Medytox Solutions, Inc.;Medytox Solutions, Inc.;Rose Rock Midstream
;Cardio3 BioSciences;LRR Energy, L.P.;Palmetto Bancshares, Inc.;New Penn;CareWell Urgent Care;MedImmune;Early Warning;CUR Media, Inc.;Fortress Biotech, Inc.;Kajeet;LinnCo, LLC;Bleckmann;Nordson Corporation;The Burlington Capital Group;Materialise;LinnCo LLC;Targa Resources Corp.;Cardio3 BioSciences;Juno Therapeutics, Inc.;Margaritaville Enterprises ;Diamondback Energy, Inc.;Fliphound ;SEPHORA;Florida Turbine Technologies, Inc.;Amazing Charts;Cancer Genetics, Inc.;Toyota;ProSyst;GreenPocket;Sorrento Therapeutics, Inc.;SmallCapVoice.com, Inc.;ReviveHealth;ReviveHealth;MeadWestvaco Corporation;Cancer Genetics, Inc.;Legacy Education Alliance, Inc.;StationDigital Corporation;VaultLogix;bluebird bio, Inc. ;Sprott Physical Gold Trust;Sprott Physical Silver Trust;OxySure Systems, Inc.;Appliance Recycling Centers of America;Ecobank;Pacific Coast Producers ;The Hamburg Port Authority;Open Access Technology International;LinnCo, LLC ;AppYea, Inc.;Valeant Pharmaceuticals International, Inc.;Pazoo, Inc.;ZenBanx Holding Ltd.;Jonas Fitness;Cancer Genetics Inc., Giggles N' Hugs Inc.;Intrexon Corporation;Building Materials Holding Corporation ;SmallCapVoice.com;Tokio Marine Holdings, Inc.;Nuveen Investments;Rambam Health Care Campus;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Jamba Juice;Harmonix Music Systems, Inc.;Merz North America, Inc.;HNA Group;Sprott Inc.;Mediacom Communications Corporation;Calpian, Inc.;Marriott International;Colliers International Group Inc ;Colliers International Group Inc.;Kofi Annan Foundation;bluebird bio, Inc.;KKM Financial;Martha Stewart Living Omnimedia, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Sprott Physical Gold Trust;Chris4Life Colon Cancer Foundation;Dinaco;ZestFinance;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Rhonda's Kiss;Usina Sao Martinho;LinnCo, LLC;LinnCo, LLC;Freescale Semiconductor ;Rose Rock Midstream;LinnCo, LLC;LinnCo, LLC;LinnCo, LLC;Sprott Physical Gold Trust;Sprott Physical Silver
Trust;Fifth Street Senior Floating Rate Corp.;Fifth Street Senior Floating Rate Corp.;Professional Diversity Network, Inc., Lightbridge Corp., Energy Fuels, Inc., Methes Energies International Ltd.;Calpian, Inc., Legacy Education Alliance, Inc., Bitcoin Shop, Inc., Lattice Incorporated;U-Vend,Inc.;Apollo Medical Holdings, Inc.;BioCorRx, Inc.;Intrexon Corporation;SSP;Royal Philips;New Generation Consumer Group, Inc.;Midrex Technologies, Inc.;RFMW Ltd.;Shenandoah Telecommunications Co;Medical Marijuana, Inc.;University of Colorado;LinnCo, LLC;Jiangsu Hengrui Medicine Co., Ltd.;Legacy Education Alliance, Inc.;Tekmira Pharmaceuticals Corporation;Diamondback Energy, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;LinnCo, LLC ;Pascack Bancorp, Inc.;National Charity League, Inc., Glendale Chapter;Windstream ;Diamondback Energy, Inc.;Acasti Pharma Inc.;Rose Rock Midstream L.P.;SemGroup Corporation;Sprott Physical Gold Trust;Sprott Physical Silver Trust;New Penn;Reddaway;Holland;Merck;Genome Compiler Corp.;Shenandoah Telecommunications Co;Rethink Robotics;New Penn;Reddaway;Holland;Cancer Genetics, Inc.;Apollo Medical Holdings, Orbital Tracking;Zimbra;Visible Alpha;Immuron Limited;Lattice Incorporated ;Legacy Education Alliance, Inc.;LinnCo, LLC ;STEMCELL Technologies;State Investors Bancorp, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Blyth, Inc.;Shared-Use Mobility Center;LinnCo, LLC;LinnCo, LLC ;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Reddaway, Holland;American Water Works;Apollo Medical Holdings;A.H. Belo;Global Brands Group Holding Limited;Sprott Physical Gold Trust;Sprott Physical Silver Trust
;Independence Holding Company;Imagine Communications Corp.;E4 Computer Engineering;Collagen Solutions plc;BNY Mellon;Dynetics Inc.;Sirona Dental Systems Inc.;Square 1 Financial, Inc.;Medical Marijuana, Inc.;BASF;Intrexon Corporation;Pineapple Express, Inc.;TeamConnor Childhood Cancer Foundation;Cabinet Grow, Inc.;CenterPoint Energy, Inc.;Transeastern Power Trust;Baxalta Incorporated;Targa Resources Corp.;LinnCo, LLC;AD;Domain Real Estate Partners, LLC ;Intrexon Corporation;Transeastern Power Trust;Rose Rock Midstream, L.P.;NewBridge Bancorp;AppYea Inc.;Distilled Spirits Council;Infor;Bristol-Myers Squibb;ARMO BioSciences, Inc.;Envestnet;Terra Tech Corp.;Targa Resources Corp.;SmartCard Marketing Systems;Linn Co, LLC;Green Plains Partners LP;Foundation for a Drug-Free World;Sprott Physical Gold Trust;Sprott Physical Gold Trust;Reis, Inc;TriVascular Technologies, Inc.;LinnCo;PositiveID Corporation;State Investors Bancorp, Inc.;Viper Energy Partners LP;Furmanite Corporation;Western Refining, Inc.;Murphy USA Inc.;Targa Resources Corp.;Diamondback Energy, Inc.;Windsor Castle Park Foundation;LinnCo;Pomerantz LLP;Baxalta Incorporated;Fifth Street Senior Floating Rate Corp. ;Momentous Entertainment Group;LinnCo, LLC;Targa Resources Partners LP;SemGroup Corporation;UIL Holdings Corporation;TriVascular Technologies, Inc.;AEON Clinical Laboratories;Sprott Physical Gold Trust, Sprott Physical Silver Trust;Capital Bank Financial Corp. ;Rocky Mountain Ayre, Inc.;SmartCard Marketing Systems Inc.;STG Group, Inc.;STG Group, Inc.;Sprott Physical Gold Trust, Sprott Physical Silver Trust;Trax;BioElectronics Corporation;Seen On Screen TV, Inc.;Targa Resources Corp.;Sprott Physical Gold Trust,Sprott Physical Silver Trust;Rose Rock Midstream, L.P.;Sprott Physical Gold Trust, Sprott Physical Silver Trust;Wilshire Bancorp, Inc.;Wilshire Bancorp, Inc.;Broadcom Corporation;The Johnson Studio;Sprott Physical Gold Trust, Sprott Physical Silver Trust;BASF;Sprott Physical Gold Trust, Sprott Physical Silver Trust;Daiichi Sankyo, Inc.;American Securities, P2 Capital Partners;Borsa Istanbul;Towers Watson;Zenbanx;Zenbanx;Hopewell Valley Community Bank;Pierre Fabre Laboratories;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Sprott Physical Gold Trust;TowneBank;Hopkins Bancorp, Inc.;Baxalta Incorporated;Western Refining, Inc.;Terra Tech Corp.;Turkcell;Intrexon Corporation;Independence Holding Company;Cape Bancorp, Inc.;Tel Aviv Stock Exchange;The General;The Conservation Fund;CenterPoint Energy, Inc.;Auscrete Corporation;Rose Rock Midstream, L.P.;Baxalta Incorporated;Anchor BanCorp Wisconsin Inc.;Envoy Group Corp.; Sprott Physical Gold Trust;LATAM Airlines Group;LocalVox;Sprott Physical Gold Trust;LinnCo, LLC;PositiveID Corporation;Strategic Rare Earth Metals;Green Plains Partners LP;Rose Rock Midstream, LP;Broadcom Corporation;Healios;Harland Clarke;DCP Midstream, LLC;Dyn, Inc.;FieldAware;Powerhouse Science Center;DCP Midstream;Targa Resources Partners LP;Belterra Casino Resort;LinnCo, LLC;TRIANNI, Inc.;Colgate-Palmolive Company;Blueprint;Bit Stew Systems;ALK Technologies;Rose Rock Midstream, L.P.;Targa Resources Corp.;Shenandoah Telecommunications Co;Viper Energy Partners LP;SoftBank Group Corp.;Diamondback Energy, Inc.;Aerohive Networks;Diana Fruit Co., Inc.;Healios K.K.;Harmony Bank;GasLog Partners;Kontron;Kontron;Green Plains Partners LP;Southwest Airlines Co.;Rose Rock Midstream;LinnCo, LLC;Datawatch Corporation;JAVELIN Mortgage Investment Corp.;BAI;Pomerantz LLP;Green Plains Partners LP;LinnCo, LLC;Global Boatworks Holdings, Inc.;The Center for an Agricultural Economy;SharkReach, Inc.;NightFood Holdings, Inc.;Mango Capital, Inc.;Daiichi Sankyo Oncology;Constellation;Bridge Bank;LinnCo, LLC;Rocky Mountain High Brands, Inc.;Wohl and Fruchter LLP; YRC Worldwide;Striped Pig Distillery;Pulaski Financial Corp.;American Independence Corp.;CorreLog;MonoSol Rx;USI;CenterPoint Energy, Inc.;LinnCo;Wilshire Bancorp, Inc.;Advanced Medical Isotope Corporation ;PureSnax International, Inc. ;Consensus;Rose Rock Midstream;Navios Maritime Acquisition Corporation;Polycom;LinnCo, LLC;Efma;LinnCo, LLC;Intrexon Corporation;iStream Financial Services;Roc Nation;SnipGold Corp.;Microchip Technology;PetroShare Corp.;AbbVie;Green Plain Partners LP;Rocky Mountain High Brands, Inc.;LinnCo, LLC;Black Knight Financial Services, Inc.;Advanced Analytical Technologies, Inc.;LinnCo, LLC ;Behavioral Health Center of Excellence ;Cape Bancorp, Inc.;Advanced Medical Isotope Corporation;Auscrete Corporation;Viper Energy Partners LP;Diamondback Energy, Inc.;Garmin Ltd.;Gritstone Oncology;Vifor Pharma;FlexFridge Inc.;Royal Philips;LinnCo.;ascribe;Wilshire Bancorp, Inc.;LinnCo, LLC;Hudson & Marshall;Excalibur Resources Ltd.;Wilshire Bancorp, Inc.;Medical Marijuana, Inc. ;Townsquare Media;Prime Care Technologies;Pfizer Inc. ;Interstate Batteries;Harmony Bank;Advanced Distribution Solutions, Inc.;LinnCo, LLC;LINN Energy, LLC;Avoka;Rose Rock Midstream, L.P.;Rose Rock Midstream;SnipGold Corp.;Rocky Mountain High Brands;Westwood Holdings Group, Inc.
Cadiz, Inc.;iDreamSky Technology Limited ;Impact Telecom;CNS Response, Inc.;Akers Biosciences, Inc.;Inteliquent, Inc.;Meridian Audio;Triax,Unitron Group;Triax;Unitron Group;Global Invacom Group Limited;MARUSYS;Diamondback Energy, Inc.;Fifth Street Senior Floating Rate Corp.;Fujitsu America, Inc.;CB Financial Services, Inc.;Diamondback Energy, Inc.;First Citizens Bancorporation, Inc.;ZAIS Group, LLC;Udi's Gluten Free;LinnCo, LLC;Blue Bird Corporation;CB Financial Services, Inc.;Nielsen;Rose Rock Midstream;Western Refining, Inc.;CB Financial Services, Inc.;7digital;Horizon Technology Finance Corporation;Bernstein Litowitz Berger & Grossmann LLP ;Fifth Street Senior Floating Rate Corp.;LinnCo, LLC;LinnCo, LLC;Globe Specialty Metals Inc. ;The Channel Company;American Water Works Company, Inc.;Top Ships, Inc.;Energy Fuels, Inc.;ForceField Energy, Inc.;Profire Energy, Inc.;InterCloud Systems, Inc.;Lattice, Inc.;GlyEco, Inc.;Quadrant 4 System Corp.;Bitcoin Shop, Inc.;Iveda Solutions, Inc., Direct Insite Corp., Drone Aviation Holding Corp., Big North Graphite Corp., The Coin Tree;Starstream Entertainment, Inc., Giggles N' Hugs, Inc., StationDigital Corp., Exeo Entertainment, Inc., I-Tap, Inc.;Clal Biotechnology Industries Ltd.;Presbyterian Senior Living;Actinium Pharmaceuticals, Inc.;Pac-12 Networks;NETGEAR, Akers Biosciences, TOP Ships;Rose Rock Midstream, L.P.;LinnCo, LLC;SoftIron;Cosmodyne, LLC;Cosmodyne, LLC;aioTV;Fyffes;Targa Resources Corp.;Western Refining, Inc.;Targa Resources Corp. ;Diamondback Energy, Inc.;Azteca America;Fundacion Azteca America;RBC Wealth Management;RBC Wealth Management;Targa Resources Corp.;BBC Worldwide;Market America, Inc. & SHOP.COM;LinnCo, LLC;eBay;Baker Donelson;Riverside Bank;Viper Energy Partners LP;Takeda Pharmaceutical Company Limited;OxySure Systems, Inc.;Southwest Airlines;LinnCo, LLC;Berkshire Hills Bancorp, Inc.;The Care and Concern Free Health Clinic;LifeLock, Inc.;Diamondback Energy, Inc.;Panasonic Corporation;Actinium Pharmaceuticals;SemGroup Corporation;Rose Rock Midstream L.P.;Fifth Street Senior Floating Rate Corp.;Valley Community Bank ;Actinium Pharmaceuticals, Inc.;Aptys Solutions;Cancer Genetics, Inc. ;E4 Computer Engineering;NXP Semiconductors N.V.;Bristol-Myers Squibb Company, Pfizer Inc.;Profire Energy;BNC Bancorp;Bigstock;DCR Strategies Inc. | TruCash;Akers Biosciences Inc.;OxySure Systems, Inc.;NETGEAR;TESARO, Inc.;Lattice Incorporated;Perritt Capital Management;Merck;Holland;Bristol-Myers Squibb;GlyEco, Inc.;LinnCo, LLC;The Home Depot;Lionbridge Technologies, Inc.;NatureWorks;TriQuint Semiconductor, Inc. ;Perspecta Trust LLC ;Fluor Corporation ;Rose Rock Midstream, L.P.;j2 Global;INC Research, Inc. ;Targa Resources Corp.;Holland;Women's Health USA;BillerudKorsnas AB;Oregon Health & Science University;LinnCo, LLC ;Y-TEC;Beyond Semiconductor;Trulia, Inc.;Holland;Diamondback Energy, Inc.;Federal Home Loan Bank of Seattle ;Phoenix Bancorp, Inc.;State Investors Bancorp, Inc. ;LinnCo, LLC;Akers Biosciences, Inc.;Sensory, Inc.;Targa Resources Corp.;American Red Cross;ProSyst;Otsuka Pharmaceutical Development & Commercialization, Inc.;Fifth Street Senior Floating Rate Corp.;Leapfrog;Phoenix Bancorp, Inc.;Cash Connect;Loomis;OnCore Biopharma, Inc.;Invetech Pty Ltd;Giggles N' Hugs, Inc.;LINN Energy, LLC;Princess Grace Hospital;Jack I. Zwick, Esq.;eWorld Companies, Inc.;Diamondback Energy, Inc.;NeuroBioPharm Inc.;Targa Resources Corp.;All Medical Solutions;The Medical Alliance, Inc.;Holland;SQN Banking Systems;Energy Fuels, Inc., Trecora Resources, Zivo Bioscience, Inc., AV Therapeutics, Inc., Lattice, Inc.;Targa Resources Corp. ;Cell Therapy Catapult;Allpoint Network;Targa Resources Partners LP;Rose Rock Midstream, L.P. ;Targa Resources Partners LP;ForceField Energy Inc.;Rose Rock Midstream, L.P.;Bristol Myers-Squibb;LinnCo, LLC;MaxLinear, Inc.;LinnCo, LLC;Acasti Pharma Inc.;Discovery Center of Idaho ;Courier Corporation ;QEST;LinnCo, LLC;BMV Group;Diamondback Energy, Inc.;Facilis Technology;Expedia, Inc.;Targa Resources Corp.;Viper Energy Partners LP;BMC Software, Inc. ;Centrosolar America, Inc.;Hanse Orga;Diamondback Energy, Inc.;OncoSec Medical Inc.;Stemgent;RM Auctions;LinnCo, LLC;AV Therapeutics, Inc.;Kyocera Communications Inc.;Walgreens;Liberty Mutual Insurance;Rose Rock Midstream, L.P.;Qualys, Inc.;Rose Rock Midstream;SemGroup Corporation;Reddaway;Federal Home Loan Bank of Seattle;MaxLinear, Inc.;Targa Resources Partners LP;NantHealth;LinnCo, LLC;thePlatform;Alliance Bancorp, Inc. of Pennsylvania;American Airlines Center;Bell Helicopter;Northpointe Bank;YRC Freight;Trading Technologies;OptionsCity Software;Orc;Quadrant 4 Systems Corp;OxySure Systems Inc;Lattice Inc.;Asia Pacific Stock Exchange;Inovalon;Nintendo Co., Ltd.;GridPoint;Holland;Pacific Coast Producers;Acasti Pharma Inc.;Noble Markets;Courier Corporation;LinnCo, LLC, Quantum Energy Partners ;YRC Freight;Rose Rock Midstream;CUR Media, Legacy Education Alliance, Apollo Medical Holdings;Fujifilm Holdings Corporation;Intrexon Corporation;Bitcoin Shop Inc.;Towers Watson & Co;Servier;Sporting Kansas City;LinnCo, LLC ;OxySure Systems, Inc.;Comptel Oyj;LinnCo, LLC;Putnam County Savings Bank;Outbrain Inc.;Squalan Natural Health B.V.;Lattice Incorporated;Trinity Health;Buena Vida Media;1347 Property Insurance Holdings, Inc., Cancer Genetics, Inc., Galectin Therapeutics, Inc., OxySure Systems, Inc., TOP Ships, Inc.;Asure Software, Inc.;CUR Media, Inc.;Bitcoin Shop, Inc.;Giggles N� Hugs, Inc.;Vapir Enterprises, Inc. ;Lightbridge Corp.;Profire Energy, Inc.;Lattice, Inc.;StationDigital, Inc.;Texas Rare Earth Resources, Inc.;Cardio3 BioSciences;Akers Biosciences, Inc., Arch Therapeutics, Inc., Zivo Bioscience, Inc., AV Therapeutics, Inc., Legacy Education Alliance, Inc.;Medytox Solutions, Inc.;Medytox Solutions, Inc.;Rose Rock Midstream
;Cardio3 BioSciences;LRR Energy, L.P.;Palmetto Bancshares, Inc.;New Penn;CareWell Urgent Care;MedImmune;Early Warning;CUR Media, Inc.;Fortress Biotech, Inc.;Kajeet;LinnCo, LLC;Bleckmann;Nordson Corporation;The Burlington Capital Group;Materialise;LinnCo LLC;Targa Resources Corp.;Cardio3 BioSciences;Juno Therapeutics, Inc.;Margaritaville Enterprises ;Diamondback Energy, Inc.;Fliphound ;SEPHORA;Florida Turbine Technologies, Inc.;Amazing Charts;Cancer Genetics, Inc.;Toyota;ProSyst;GreenPocket;Sorrento Therapeutics, Inc.;SmallCapVoice.com, Inc.;ReviveHealth;ReviveHealth;MeadWestvaco Corporation;Cancer Genetics, Inc.;Legacy Education Alliance, Inc.;StationDigital Corporation;VaultLogix;bluebird bio, Inc. ;Sprott Physical Gold Trust;Sprott Physical Silver Trust;OxySure Systems, Inc.;Appliance Recycling Centers of America;Ecobank;Pacific Coast Producers ;The Hamburg Port Authority;Open Access Technology International;LinnCo, LLC ;AppYea, Inc.;Valeant Pharmaceuticals International, Inc.;Pazoo, Inc.;ZenBanx Holding Ltd.;Jonas Fitness;Cancer Genetics Inc., Giggles N' Hugs Inc.;Intrexon Corporation;Building Materials Holding Corporation ;SmallCapVoice.com;Tokio Marine Holdings, Inc.;Nuveen Investments;Rambam Health Care Campus;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Jamba Juice;Harmonix Music Systems, Inc.;Merz North America, Inc.;HNA Group;Sprott Inc.;Mediacom Communications Corporation;Calpian, Inc.;Marriott International;Colliers International Group Inc ;Colliers International Group Inc.;Kofi Annan Foundation;bluebird bio, Inc.;KKM Financial;Martha Stewart Living Omnimedia, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Sprott Physical Gold Trust;Chris4Life Colon Cancer Foundation;Dinaco;ZestFinance;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Rhonda's Kiss;Usina Sao Martinho;LinnCo, LLC;LinnCo, LLC;Freescale Semiconductor ;Rose Rock Midstream;LinnCo, LLC;LinnCo, LLC;LinnCo, LLC;Sprott Physical Gold Trust;Sprott Physical Silver
Trust;Fifth Street Senior Floating Rate Corp.;Fifth Street Senior Floating Rate Corp.;Professional Diversity Network, Inc., Lightbridge Corp., Energy Fuels, Inc., Methes Energies International Ltd.;Calpian, Inc., Legacy Education Alliance, Inc., Bitcoin Shop, Inc., Lattice Incorporated;U-Vend,Inc.;Apollo Medical Holdings, Inc.;BioCorRx, Inc.;Intrexon Corporation;SSP;Royal Philips;New Generation Consumer Group, Inc.;Midrex Technologies, Inc.;RFMW Ltd.;Shenandoah Telecommunications Co;Medical Marijuana, Inc.;University of Colorado;LinnCo, LLC;Jiangsu Hengrui Medicine Co., Ltd.;Legacy Education Alliance, Inc.;Tekmira Pharmaceuticals Corporation;Diamondback Energy, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;LinnCo, LLC ;Pascack Bancorp, Inc.;National Charity League, Inc., Glendale Chapter;Windstream ;Diamondback Energy, Inc.;Acasti Pharma Inc.;Rose Rock Midstream L.P.;SemGroup Corporation;Sprott Physical Gold Trust;Sprott Physical Silver Trust;New Penn;Reddaway;Holland;Merck;Genome Compiler Corp.;Shenandoah Telecommunications Co;Rethink Robotics;New Penn;Reddaway;Holland;Cancer Genetics, Inc.;Apollo Medical Holdings, Orbital Tracking;Zimbra;Visible Alpha;Immuron Limited;Lattice Incorporated ;Legacy Education Alliance, Inc.;LinnCo, LLC ;STEMCELL Technologies;State Investors Bancorp, Inc.;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Blyth, Inc.;Shared-Use Mobility Center;LinnCo, LLC;LinnCo, LLC ;Sprott Physical Gold Trust;Sprott Physical Silver Trust;Reddaway, Holland;American Water Works;Apollo Medical Holdings;A.H. Belo;Global Brands Group Holding Limited;Sprott Physical Gold Trust;Sprott Physical Silver Trust
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Sprott Physical Gold Trust;LATAM Airlines Group;LocalVox;Sprott Physical Gold Trust;LinnCo, LLC;PositiveID Corporation;Strategic Rare Earth Metals;Green Plains Partners LP;Rose Rock Midstream, LP;Broadcom Corporation;Healios;Harland Clarke;DCP Midstream, LLC;Dyn, Inc.;FieldAware;Powerhouse Science Center;DCP Midstream;Targa Resources Partners LP;Belterra Casino Resort;LinnCo, LLC;TRIANNI, Inc.;Colgate-Palmolive Company;Blueprint;Bit Stew Systems;ALK Technologies;Rose Rock Midstream, L.P.;Targa Resources Corp.;Shenandoah Telecommunications Co;Viper Energy Partners LP;SoftBank Group Corp.;Diamondback Energy, Inc.;Aerohive Networks;Diana Fruit Co., Inc.;Healios K.K.;Harmony Bank;GasLog Partners;Kontron;Kontron;Green Plains Partners LP;Southwest Airlines Co.;Rose Rock Midstream;LinnCo, LLC;Datawatch Corporation;JAVELIN Mortgage Investment Corp.;BAI;Pomerantz LLP;Green Plains Partners LP;LinnCo, LLC;Global Boatworks Holdings, Inc.;The Center for an Agricultural Economy;SharkReach, Inc.;NightFood Holdings, Inc.;Mango Capital, Inc.;Daiichi Sankyo Oncology;Constellation;Bridge Bank;LinnCo, LLC;Rocky Mountain High Brands, Inc.;Wohl and Fruchter LLP; 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REDWOOD CITY, Calif., and BANNOCKBURN, Ill., Jan. 11, 2016 (GLOBE NEWSWIRE) -- Coherus BioSciences, Inc. (NASDAQ:CHRS) and Baxalta Incorporated (NYSE:BXLT) today announced that CHS-0214, a proposed biosimilar of Enbrel® (etanercept), met its primary endpoint in a confirmatory, double-blind, randomized, controlled, two-part clinical study. This ongoing study is evaluating the efficacy and safety of CHS-0214 compared to Enbrel in patients with moderate-to-severe rheumatoid arthritis that is inadequately controlled with methotrexate alone. The study continues as planned until Week 52.
The primary efficacy endpoint was the proportion of subjects achieving ACR20 (20% improvement according to the American College of Rheumatology criteria) at Week 24. The primary endpoint was within the pre-specified margins for demonstrating equivalence of CHS-0214 compared to Enbrel. There were no clinically meaningful differences in the safety and immunogenicity profiles of the two products.
“Rheumatoid arthritis that remains active despite methotrexate treatment has a significant impact on a patient’s health and quality of life,” said Barbara Finck, M.D., Chief Medical Officer of Coherus. “If approved, CHS-0214 has the potential to expand access and treatment options for patients with moderate-to-severe rheumatoid arthritis and other inflammatory diseases for which etanercept is indicated.”
This rheumatoid arthritis study is the second of two, large, Phase 3 confirmatory trials intended for inclusion in global marketing applications for CHS-0214. Results for the first Phase 3 study in patients with chronic plaque psoriasis were released in November 2015 and showed that this first study also met its primary endpoints.
“We are pleased that this second pivotal clinical study comparing CHS-0214 to Enbrel has met its primary endpoint,” said Denny Lanfear, President and Chief Executive Officer of Coherus. “We look forward to advancing this product to registration in various territories in 2016.”
“Etanercept transformed the treatment for many with moderate-to-severe rheumatoid arthritis and other inflammatory conditions, significantly improving patients’ quality of life,” said Dagmar Rosa-Björkeson, Executive Vice President and President, Biosimilars of Baxalta. “This important clinical milestone, adding to previously-announced positive data in patients with chronic plaque psoriasis, brings us one step closer to expanding treatment options for patients.”
About CHS-0214, a proposed biosimilar of Enbrel® (etanercept)
CHS-0214 was evaluated in two comprehensive single-dose, cross-over pharmacokinetic / bioequivalence (PK / BE) studies in healthy volunteers. In both trials, CHS-0214 demonstrated PK similarity to Enbrel® based on pre-specified pharmacokinetic criteria. The safety profiles of CHS-0214 and Enbrel® were similar in these studies.
CHS-0214 was also evaluated in a confirmatory, double-blind, randomized, controlled, two-part Phase 3 study in patients with moderate-to-severe chronic plaque psoriasis. At Week 12, the primary endpoints, the mean percent change in PASI from baseline and the proportion of subjects achieving 75% improvement in PASI from baseline, were within the pre-specified margins for demonstrating equivalence of CHS-0214 compared to Enbrel® . There were no clinically meaningful differences in the safety profiles of the products.
About Coherus BioSciences, Inc.
Coherus is a leading pure-play global biosimilar platform company that develops and commercializes high-quality therapeutics for major regulated markets. Biosimilars are intended for use in place of existing, branded biologics to treat a range of chronic and often life-threatening diseases, with the potential to reduce costs and expand patient access. Composed of a team of proven industry veterans with world-class expertise in process science, analytical characterization, protein production and clinical-regulatory development, Coherus is positioned as a leader in the global biosimilar marketplace. Coherus is advancing three late-stage clinical products towards commercialization, CHS-1701 (pegfilgrastim biosimilar), CHS-0214 (etanercept biosimilar) and CHS-1420 (adalimumab biosimilar), as well as developing a robust pipeline of future products. For additional information, please visit www.coherus.com .
Forward Looking Statement For Coherus
To the extent that statements contained in this press release are not descriptions of historical facts regarding Coherus, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including statements regarding the ability of Coherus to obtain regulatory approvals on its desired timelines and the potential benefits of CHS-0214. Such forward-looking statements involve substantial risks and uncertainties that relate to future events and the actual results could differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the biosimilar development process, including the regulatory approval process, the timing of the actions of regulatory bodies and other governmental authorities, clinical results, changes in laws and regulations, product quality or supply for CHS-0214 and Enbrel®, patient safety and patent litigation. Coherus undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the company in general, see the company's current and future reports filed with the U.S. Securities and Exchange Commission, including its Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2015.
About Baxalta Incorporated
Baxalta Incorporated (NYSE:BXLT) is a $6 billion global biopharmaceutical leader developing, manufacturing and commercializing therapies for orphan diseases and underserved conditions in hematology, oncology and immunology. Driven by passion to make a meaningful impact on patients’ lives, Baxalta’s broad and diverse pipeline includes biologics with novel mechanisms and advanced technology platforms such as gene therapy. The Baxalta Global Innovation and R&D Center is located in Cambridge, Massachusetts. Launched in 2015 following separation from Baxter International, Baxalta’s heritage in biopharmaceuticals spans decades. Baxalta’s therapies are available in more than 100 countries and it has advanced biological manufacturing operations across 12 facilities, including state-of-the-art recombinant production and plasma fractionation. Headquartered in Northern Illinois, Baxalta employs 16,000 employees worldwide.
Forward Looking Statement For Baxalta
This release includes forward-looking statements concerning Baxalta’s collaboration with Coherus on CHS-0214, including expectations with regard to future regulatory actions and potential impact on patients. Such statements are made of the date that they were first issued and are based on current expectations, beliefs and assumptions of management. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond Baxalta's control and which could cause actual results to differ materially from those in the forward-looking statements, including the following: clinical trial results; satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; changes in laws and regulations; product quality, manufacturing or supply issues; patient safety issues; and other risks identified in Baxalta's Registration Statement on Form 10 and other Securities and Exchange Commission filings, all of which are available on Baxalta's website. Baxalta expressly disclaims any intent or obligation to update these forward-looking statements except as required by law.
Enbrel® is a registered trademark of Amgen, Inc.
COHERUS INVESTOR AND MEDIA CONTACT:
Keith Vendola, M.D. kvendola@coherus.com +1 (650) 437-6239
BAXALTA INVESTOR CONTACT:
Mary Kay Ladone mary.kay.ladone@baxalta.com +1 (224) 948-3371
Lorna Williams lorna.williams@baxalta.com +1 (224) 948-3511
BAXALTA MEDIA CONTACT: Albert Liao media@baxalta.com +1 (617) 834-9285