Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 13 June 2016, the interest of Pascal Soriot, a person discharging managerial
responsibilities, in the ordinary shares of AstraZeneca PLC changed as detailed
below.

The change in interest relates to the vesting of an award of shares made in June
2013 under the AstraZeneca Performance Share Plan.

Following the application of performance measures specified at the time of
grant, Mr Soriot has become beneficially entitled to 78% of the shares
originally awarded. In accordance with the plan rules, any unvested part of the
award has immediately and irrevocably lapsed.

After sufficient vested shares were withheld to satisfy certain tax obligations
arising on the vesting, Mr Soriot has become beneficially entitled to and has
received 84,316 shares into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was 3852 pence per
share being the closing price of AstraZeneca ordinary shares on the last trading
day preceding the vesting day.

A C N Kemp
Company Secretary
14 June 2016