Director/PDMR Shareholding


26 September 2016 16:00

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 26 September 2016, the interest of Sean Bohen, a person discharging
managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed
as detailed below.

The change in interest relates to the vesting of an award of AstraZeneca
American Depositary Shares (ADSs) made in September 2015 under the AstraZeneca
Restricted Share Plan.

One ordinary share equals two ADSs.

After sufficient vested shares were withheld to satisfy certain tax obligations
arising on the vesting, Mr Bohen has become beneficially entitled to and has
received 12,385 ADSs into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was $33.97 per ADS
being the closing price on the last trading day preceding the vesting day.

The attached notification, made in accordance with the requirements of the EU
Market Abuse Regulation, gives further detail.

Notification and public disclosure of transactions by persons discharging
managerial responsibilities and persons closely associated with them

1       Details of the person discharging
        managerial responsibilities / person
        closely associated
a)      Name                                 Sean Bohen
2       Reason for the notification
a)      Position/status                      Executive
                                             Vice
                                             -President,
                                             Global
                                             Medicines
                                             Development
                                             and Chief
                                             Medical
                                             Officer
b)      Initial notification /Amendment      Initial
                                             notification
3       Details of the issuer, emission
        allowance market participant, auction
        platform, auctioneer or auction monitor
a)      Name                                 AstraZeneca
                                             PLC
b)      LEI                                  Not
                                             applicable
4       Details of the transaction(s): section
        to be repeated for (i) each type of
        instrument; (ii) each type of
        transaction; (iii) each date; and (iv)
        each place where transactions have been
        conducted
a)      Description of the financial         AstraZeneca
        instrument, type of instrument       PLC American
        Identification code                  Depositary
                                             Shares
                                             CUSIP:
                                             046353108
b)      Nature of the transaction            Acquisition
                                             of
                                             AstraZeneca
                                             American
                                             Depositary
                                             Shares
                                             pursuant to
                                             the vesting
                                             of an award
                                             under the
                                             AstraZeneca
                                             Restricted
                                             Share Plan
c)      Price(s) and volume(s)                Price(s)        Volume(s)
             12,385
$33.97
d)      Aggregated information - Aggregated  Not
        volume - Price                       applicable -
                                             single
                                             transaction
e)      Date of the transaction              26 September
                                             2016
f)      Place of the transaction             New York

About AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company that focuses on
the discovery, development and commercialisation of prescription medicines,
primarily for the treatment of diseases in three therapy areas - Respiratory and
Autoimmunity, Cardiovascular and Metabolic Diseases, and Oncology. The Company
is also active in inflammation, infection and neuroscience through numerous
collaborations. AstraZeneca operates in over 100 countries and its innovative
medicines are used by millions of patients worldwide. For more information
please visit: www.astrazeneca.com

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Toll-free                                                 +1 866 381 7277

Adrian Kemp

Company Secretary

AstraZeneca PLC

-ENDS-

Attachments

09268158.pdf