Dublin, Dec. 02, 2019 (GLOBE NEWSWIRE) -- The "Market Spotlight: Cold Agglutinin Disease" report has been added to ResearchAndMarkets.com's offering.
This report covers the Cold Agglutinin Disease market, comprising disease background and treatment information, key pipeline drugs, clinical trials, probability of success, licensing and acquisition deals, and an epidemiology overview.
Key Takeaways
- There are only two industry-sponsored drugs in active clinical development for cold agglutinin disease, with one drug each in Phase II and Phase III.
- Therapies in development for cold agglutinin disease target the complement pathway. These pipeline drugs are administered via the intravenous, subcutaneous, and intraocular/subretinal/subconjunctival routes.
- The overall likelihood of approval of a Phase I autoimmune/immunology-other asset is 21.8%, and the average probability a drug advances from Phase III is 70.5%. Drugs, on average, take 10.1 years from Phase I to approval, compared to 9.0 years in the overall autoimmune/immunology space.
- There have been only two licensing and asset acquisition deals involving cold agglutinin disease drugs during 2014-19. The largest deal was the $825m agreement in 2017 between Bioverativ and True North Therapeutics for the acquisition of TNT009 (now referred to as BIVV009 or sutimlimab).
- The distribution of clinical trials across Phase I-III indicates that the majority of trials for cold agglutinin disease have been in the early and mid-phases of development, with 62.5% of trials in Phase I-II, and only 37.5% in Phase III.
- The majority of clinical trial activity in the cold agglutinin disease space comprises completed trials.
- Sanofi leads industry sponsors with the highest number of clinical trials for cold agglutinin disease.
Key Topics Covered
OVERVIEW
KEY TAKEAWAYS
DISEASE BACKGROUND
Disease definition
Patient subtypes
Symptoms
Risk factors
Diagnosis
TREATMENT
Non-pharmacological treatment
Pharmacological treatment
EPIDEMIOLOGY
PIPELINE DRUGS
PROBABILITY OF SUCCESS
LICENSING AND ASSET ACQUISITION DEALS
PARENT PATENTS
CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase
BIBLIOGRAPHY
APPENDIX
LIST OF FIGURES
Figure 1: Overview of pipeline drugs for cold agglutinin disease in the US
Figure 2: Pipeline drugs for cold agglutinin disease, by company
Figure 3: Pipeline drugs for cold agglutinin disease, by drug type
Figure 4: Pipeline drugs for cold agglutinin disease, by classification
Figure 5: Probability of success in the cold agglutinin disease pipeline
Figure 6: Licensing and asset acquisition deals in cold agglutinin disease, 2014-19
Figure 7: Clinical trials in cold agglutinin disease
Figure 8: Top 10 drugs for clinical trials in cold agglutinin disease
Figure 9: Top 10 companies for clinical trials in cold agglutinin disease
Figure 10: Cold agglutinin disease trials status
Figure 11: Cold agglutinin disease trials sponsors, by phase
LIST OF TABLES
Table 1: Pipeline drugs for cold agglutinin disease in the US
Table 2: Parent patents in cold agglutinin disease
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