(upper), Ordered heat maps show the detection of known variants (rows) in ctDNA assay replicates (columns). All on-target variants for a given assay are shown. Variants are sorted by expected VAF in descending order, and replicates are arranged hierarchically by assay type, test lab and replicate number. Heat maps show results for Lbx-low at 25 ng input. (lower), Aligned below each heat map column, bar charts indicate the sensitivity of variant detection in each replicate. Sensitivity is reported separately for known variants in the following VAF ranges: 2.5–0.5%, 0.5–0.3%, 0.3–0.2% and 0.2–0.1%, with measurements taken from both Lbx-high (high and mid VAF) and Lbx-low (low VAF).
(upper), Ordered heat maps show the detection of known variants (rows) in ctDNA assay replicates (columns). All on-target variants for a given assay are shown. Variants are sorted by expected VAF in descending order, and replicates are arranged hierarchically by assay type, test lab and replicate number. Heat maps show results for Lbx-low at 25 ng input. (lower), Aligned below each heat map column, bar charts indicate the sensitivity of variant detection in each replicate. Sensitivity is reported separately for known variants in the following VAF ranges: 2.5–0.5%, 0.5–0.3%, 0.3–0.2% and 0.2–0.1%, with measurements taken from both Lbx-high (high and mid VAF) and Lbx-low (low VAF).