Biochemical pathways for the supply of deoxyribonucleoside triphosphate (dATP, dGTP, dCTP, and dTTP) pools. The salvage pathway becomes upregulated during autoimmune diseases and cancer. TRE-515 blocks the enzyme deoxycytidine kinase (dCK) in the deoxyribonucleoside salvage pathway.
Biochemical pathways for the supply of deoxyribonucleoside triphosphate (dATP, dGTP, dCTP, and dTTP) pools. The salvage pathway becomes upregulated during autoimmune diseases and cancer. TRE-515 blocks the enzyme deoxycytidine kinase (dCK) in the deoxyribonucleoside salvage pathway.