Three-dimensional rendering of a hepatocyte-directed vesicle (HDV), the delivery platform underlying HDV-insulin lispro. The disc-shaped phospholipid bilayer carries biotin (green) as a hepatocyte-targeting molecule and insulin lispro (yellow) bound to its surface, working together to increase hepatic insulin delivery and restore a more physiologic pattern of insulin exposure.
Three-dimensional rendering of a hepatocyte-directed vesicle (HDV), the delivery platform underlying HDV-insulin lispro. The disc-shaped phospholipid bilayer carries biotin (green) as a hepatocyte-targeting molecule and insulin lispro (yellow) bound to its surface, working together to increase hepatic insulin delivery and restore a more physiologic pattern of insulin exposure.