C57BL/6 mice (n=7/group) were untreated or were treated with ImmTOR alone, IL-2 mutein alone, or a combination of ImmTOR + IL-2 mutein. The mouse-specific IL-2 mutein was produced as described by Khoryati et al. (Sci. Immunol. , 2020, 5, eaba5264). Expansion of CD4+, CD25+, FoxP3+ T regulatory cells in the spleen was assessed 7 days after treatment. ***p<0.001, Mann-Whitney test.
C57BL/6 mice (n=7/group) were untreated or were treated with ImmTOR alone, IL-2 mutein alone, or a combination of ImmTOR + IL-2 mutein. The mouse-specific IL-2 mutein was produced as described by Khoryati et al. (Sci. Immunol. , 2020, 5, eaba5264). Expansion of CD4+, CD25+, FoxP3+ T regulatory cells in the spleen was assessed 7 days after treatment. ***p<0.001, Mann-Whitney test.