Axsome Therapeutics Announces Publication of Research Showing AXS-02 Inhibits Pain in Animal Model of Complex Regional Pain Syndrome

New York, New York, UNITED STATES

NEW YORK, Oct. 04, 2016 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ:AXSM), a clinical-stage biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, today announced the publication of data showing that AXS-02 (oral zoledronate) inhibits pain in a well-validated animal model of complex regional pain syndrome (CRPS).

The study, conducted by researchers at the Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, examined the effect of oral zoledronate on pain behavior in the rat tibia fracture model of CRPS. The study was published in the October 2016 issue of Anesthesia & Analgesia, a peer-reviewed medical journal. A link to the article abstract can be accessed on PubMed at:

Results of the study revealed that oral zoledronate (AXS-02) completely reversed established pain and improved weight bearing in the rat tibia fracture model of CRPS. Oral zoledronate also prevented the development of pain when administration was started at the time of fracture.

AXS-02 is currently in Phase 3 trials for the treatment of the pain of CRPS (the CREATE-1 trial), and the pain of knee osteoarthritis associated with bone marrow lesions (the COAST-1 trial).

About Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is a debilitating condition characterized by severe, continuous, burning or throbbing pain in a limb. The excessive pain is accompanied by changes in skin color, temperature and/or swelling. It is considered to be one of the most painful conditions, results in loss of physical function, and can lead to significant and sometimes permanent disability. There is currently no medication approved for the treatment of CRPS.

About Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, including pain, for which there are limited existing treatment options. Axsome’s product candidate portfolio includes two late-stage candidates, AXS-02 and AXS-05. AXS-02 is currently in Phase 3 trials in complex regional pain syndrome (CRPS) and knee osteoarthritis (OA) associated with bone marrow lesions (BMLs) with an additional Phase 3 trial planned in chronic low back pain (CLBP) associated with Modic changes (MCs). AXS-05 is currently in a Phase 3 trial in treatment resistant depression (TRD), and a Phase 2/3 trial in agitation in patients with Alzheimer’s disease (AD) is planned. AXS-02 and AXS-05 are investigational product candidates not approved by the FDA. For more information, please visit the company website at The company may occasionally disseminate material, nonpublic information on the company website.

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