Rhizen Pharmaceuticals S.A. announces preclinical data presentations for RP4010, a calcium release-activated calcium (CRAC) channel inhibitor and RP10107, a glutaminase inhibitor at the 2018 AACR Annual Meeting

La Chaux-de-Fonds, SWITZERLAND


La Chaux-de-Fonds, Switzerland, April 10, 2018 (GLOBE NEWSWIRE) -- Rhizen Pharmaceuticals S.A. announces preclinical data presentations for RP4010, a novel first-in-class CRAC channel inhibitor and RP10107, a novel and potent glutaminase inhibitor in hematological malignancies and solid tumors.

--- Three preclinical poster presentations highlight the potential of RP4010 and RP10107 alone and in combination with approved drugs for treating hematological malignancies and solid tumors.

About RP4010:

RP4010 is a novel first-in-class oral small molecule inhibitor of calcium release activated calcium (CRAC) channel pathway with demonstrated preclinical activity in a broad range of cancers.   Aberrant CRAC channel activity has been linked to various autoimmune disorders and certain cancers via the NFAT pathway.  In addition, the blockage of store-operated calcium entry (SOCE) by a CRAC channel inhibitor could suppress tumor growth through a number of mechanisms, including the inhibition of calcium-dependent activation of Akt/NF-kB and ERK 1/2 pathways.  A multi-center Phase I/IB dose-escalation trial evaluating the safety and efficacy of RP4010, a CRAC channel inhibitor in patients with relapsed or refractory Lymphomas is currently ongoing in USA (ClinicalTrials.gov Identifier: NCT03119467).

About RP10107:

RP10107 is a novel and potent glutaminase inhibitor in late preclinical development with demonstrated preclinical activity in a broad range of cancers.  Glutaminase enzyme, which converts glutamine to glutamate, has been identified as a critical choke point in the utilization of glutamine by cancer cells.  These research findings point to the utility of a glutaminase inhibitor in treating glutamine-dependent cancers either alone or in combination with standard of care drugs.

Details of the poster presentations:

-- Poster Title:  Store-operated calcium signaling is an effective therapeutic target in AML

  • Session Category:                  Experimental and Molecular Therapeutics
  • Session Title:                         New Targets 1 
  • Session Date & Time:             Monday, April 16, 2018; 8:00 AM – 12:00 PM
  • Location:                               McCormick Place South, Exhibit Hall A, Poster Section 40
  • Poster Board Number:            13

-- Poster Title:  Synergistic effects of glutaminase and proteasome inhibition in multiple myeloma cell lines

  • Session Category:                  Experimental and Molecular Therapeutics
  • Session Title:                         Agents and Combination for Hematological Malignancies 2
  • Session Date & Time:             Monday, April 16, 2018; 8:00 AM – 12:00 PM
  • Location:                               McCormick Place South, Exhibit Hall A, Poster Section 38
  • Poster Board Number:            20

-- Poster Title:  Addition of RP10107, a novel and potent glutaminase inhibitor, accentuates 5-FU activity in lung cancer cell lines in vitro

  • Session Category:                  Experimental and Molecular Therapeutics
  • Session Title:                         Novel Targets and Inhibitors
  • Session Date & Time:             Tuesday, April 17, 2018; 1:00 PM – 5:00 PM
  • Location:                               McCormick Place South, Exhibit Hall A, Poster Section 39
  • Poster Board Number:            20

About Rhizen Pharmaceuticals S.A.:

Rhizen Pharmaceuticals is an innovative, clinical-stage biopharmaceutical company focused on the discovery and development of novel therapeutics for the treatment of cancer, immune and metabolic disorders.  Since its establishment in 2008, Rhizen has created a diverse pipeline of proprietary drug candidates targeting several cancers and immune associated cellular pathways.  Rhizen is headquartered in La-Chaux-de-Fonds, Switzerland.  For additional information, please visit Rhizen’s website, www.rhizen.com.


        

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