Epidemiologic Study Findings Show 27 Percent Increase in Emergency Department Visits for Gout in the United States Over the Past Decade

-- Results reflect the undermanaged burden of uncontrolled gout --

AMSTERDAM, The Netherlands, June 14, 2018 (GLOBE NEWSWIRE) -- Results from a new study presented in an oral presentation at the Annual European Congress of Rheumatology (EULAR 2018) show a dramatic 27 percent increase in emergency department (ED) visits between 2006 and 2014 for people living with gout in the United States.  Horizon Pharma provided research support and funding for this study.

"The dramatic increase in ED visits in the United States for patients with a primary diagnosis of gout over the past nine years reflects a sizeable and growing population of patients with gout whose symptoms are not controlled and not well managed,” said Gurkirpal Singh, M.D., lead study investigator and adjunct clinical professor of medicine at Stanford University.  "Often the treatment of gout focuses on alleviating the symptoms of painful gout flares.  However, when escalating symptoms reach the threshold of an ED visit, this suggests that the underlying accumulation of uric acid may not have been adequately addressed.”

Gout is a chronic, progressive inflammatory form of arthritis that is caused by excess uric acid in the body and needs to be managed aggressively.i  If uric acid levels in the blood remain elevated, thin rod-like crystals can form and deposit in the joints, which can lead to severe pain, tenderness, stiffness, swelling and joint damage.  In addition to the joint damage, urate crystals can also deposit in other organs of the body,ii and if left unmanaged, gout can lead to significant tissue damage.iii

The study Emergency Department Visits for Gout: A Dramatic Increase in the Past Decade (abstract OP0185), evaluated data from the Nationwide Emergency Department Sample (NEDS).  Dr. Singh and colleagues studied all ED visits with a primary diagnosis of gout from 2006 to 2014 and calculated the prevalence of gout in different age groups using population data from the U.S. Census Bureau.  NEDS, which yields national estimates of hospital-based ED visits, is the largest all-payer ED database in the United States, containing information from 31 million ED visits at 945 hospitals in 34 states.  The study demonstrated that the total number of ED visits per year among patients with a primary diagnosis of acute gout increased 26.8 percent between 2006 and 2014 – from 168,580 to 213,780.

Additional results showed that, over the nine-year period:

  • 1.7 million people visited EDs with a primary diagnosis of acute gout.
  • The prevalence of ED visits with a primary diagnosis of gout increased from 56.5/100,000 population in 2006 to 67/100,000 in 2014 (p<0.001).
  • The largest increase in the prevalence of ED visits occurred among people ages 45 to 64 years – a 28 percent increase from 91/100,000 in 2006 to 116/100,000 in 2014 (p<0.001).
  • Men accounted for 78 percent of the ED visits in both 2006 and 2014.

About Horizon Pharma plc
Horizon Pharma plc is focused on researching, developing and commercializing innovative medicines that address unmet treatment needs for rare and rheumatic diseases.  By fostering a growing pipeline of medicines in development and exploring all potential uses for currently marketed medicines, we strive to make a powerful difference for patients, their caregivers and physicians.  For us, it’s personal: by living up to our own potential, we are helping others live up to theirs.  For more information, please visit www.horizonpharma.com.  Follow @HZNPplc on Twitter, like us on Facebook or explore career opportunities on LinkedIn.

Tina Ventura
Senior Vice President, Investor Relations

Ruth Venning
Executive Director, Investor Relations

U.S. Media Contact:
Amanda Phraner
Senior Manager, Public Relations and Social Media

Ireland Media Contact:
Ray Gordon
Gordon MRM 

Source: Horizon Pharma plc

i Keuhn, B. Chronic Disease Approaches Needed to Curb Gout’s Growing Burden. Journal of the American Medical Association. 2018; 319(13):1308-1309.

ii Park J, Roudier M, Soman D, Mokada N, Simin P. Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study. BJM Open. 2014; 4:e005308. doi:10.1136/bmjopen-2014-005308

iii Edwards NL. Treatment-failure gout: a moving target. Arthritis Rheum. 2008;58(9):2587-2590.